Synthetic Endometrial and Uterus-Like Tissue Platforms for In Vitro Embryo Culture

Brief Description

Innovative synthetic endometrial tissues and uterus-like structures enable advanced in vitro embryo implantation, growth, and culture to model post-implantation stages.

Full Description

This technology provides methods and devices to create synthetic, vascularized endometrial tissues and uterus-like structures using co-cultured endothelial and fibroblast cells in hydrogels, facilitating embryo implantation and development in vitro. Utilizing microfluidic platforms, it mimics natural embryo-endometrium interactions, supporting mammalian embryos—including human embryos and stem cell-derived models—to transition successfully from pre- to post-implantation stages under controlled dynamic culture conditions.

Suggested uses

• Assisted reproductive technology (ART) research to improve IVF success rates. 
• Pharmaceutical development and testing targeting early pregnancy and implantation processes. 
• Stem cell and developmental biology research using embryo models. 
• Fertility clinics employing advanced embryo culture platforms for therapeutic use. 
• Biotech companies developing microfluidic and organ-on-chip technologies for reproductive health. 
• Academic research studying maternal-fetal interface and early human development. 
• Customized drug screening for pregnancy safety and efficacy evaluation.

Advantages

• Recreates vascularized, perfusable tissue microenvironments to closely simulate in vivo uterus conditions. 
• Enables extended culture of mammalian embryos, including human blastocysts, beyond implantation stages. 
• Compatible with microfluidic devices allowing precise control of physical and biochemical culture parameters. 
• Flexible hydrogel compositions allow customization of extracellular matrix components for enhanced tissue functionality. 
• Supports hormone-primed endometrial organoids and stromal cells assembly to form functional uterus-like tissues. 
• Dynamic oxygen and gas pressure regulation improves embryo developmental outcomes.
• Facilitates study of implantation failures and potential infertility solutions with in vitro human embryo models.

Patent Status

Patent Pending