System And Method Of EAT/US-Guided Pulsed Field Ablation For Intracardiac Applications

Brief Description

A real-time, ultrasound-based imaging modality that improves intracardiac irreversible electroporation accuracy by visualizing electric field distribution during cardiac ablation.

Full Description

Irreversible electroporation (IRE) is a nonthermal tissue ablation technique that causes cell death in tissue while preserving the extracellular matrix while inducing minimal inflammation, which makes it a promising treatment for intracardiac ablations, however incomplete lesion treatment leaves areas at risk of arrhythmic recurrence. This technology combines electroacoustic tomography (EAT) with intracardiac echocardiography (ICE) catheters to provide real-time imaging of electric field distributions during irreversible electroporation (IRE) cardiac ablationwhich enables real-time image guidance for cardiac ablation, minimizes collateral tissue damage, and reduces repeat interventions for cardiac arrhythmias.

Suggested uses

• Cardiac ablation procedures: Guidance and monitoring of pulsed field ablation (PFA) for arrhythmia treatment and intracardiac electroporation therapies requiring precise lesion creation and verification. 
• Clinical applications: Electrophysiology labs seeking improved ablation success rates and reduced complications, particularly for pediatric and fragile patients benefiting from nonthermal, targeted treatments. 
• Advanced interventional solutions: Development of personalized cardiac treatment devices and advanced imaging solutions for interventional cardiology that optimize energy delivery.

Advantages

• Real-time precision and safety: Visualizes electric fields and differentiates reversible vs. irreversible zones to ensure accurate lesion formation and minimize collateral damage and also supports personalized protocols and uses non-thermal ablation to avoid heat-sink effects, protecting surrounding tissues and vessels. 
• Reduced complexity: Provides immediate lesion verification and works with standard ICE catheters, reducing repeat ablations.

Patent Status

Patent Pending