Imaging Modalities and Methods for Enhanced, Label-free Histopathology During Surgery

Tech ID: 31816 / UC Case 2019-580-0


Researchers at the University of California, Davis have developed new techniques capable of producing near real-time tissue analysis with quality and accuracy attributes comparable to traditional Haemotoxylin and Eosin (H&E) histopathology methods.

Full Description

H&E methods can involve multiple tissue or biopsy preparation steps. Thus, these processes typically require elapsed times that are often incompatible with optimal intra-operative decision-making regarding the amount of tissue to be removed during surgery. Therefore, the field of pathology would be advanced – and positive surgical outcomes with reduced side effects would increase – if histopathological processes with reduced time scales were implemented.

Researchers at the University of California Davis have developed a label-free, spectral, pathology method that can quickly identify regions of diseased tissue in vivo without the need for traditional hematoxylin and eosin staining. A multimodal microscope capable of acquiring varied and simultaneous microscopy/spectroscopy images of unstained tissue can survey the tissue structure and architecture, and - by comparing unique tissue signatures provided by the microscope, discriminate between diseased and healthy cells. This method overcomes historical limitations associated with current approaches to intra-operative histopathology. 



  •         Intraoperative pathology




  •         Offers a label-free method for near, real-time pathology results
  •         Reduces average times surgical patients remain under anesthesia
  •         Increases accuracy of tissue removal during surgery


Patent Status

Patent Pending


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  • Chan, James W.
  • Saadai, Payam

Other Information


Pathology, Histopathology, Inter-operative, Label-free

Categorized As