Imaging Modalities and Methods for Enhanced, Label-free Histopathology During Surgery

Abstract

Researchers at the University of California, Davis have developed new techniques capable of producing near real-time tissue analysis with quality and accuracy attributes comparable to traditional Haemotoxylin and Eosin (H&E) histopathology methods.

Full Description

H&E methods can involve multiple tissue or biopsy preparation steps. Thus, these processes typically require elapsed times that are often incompatible with optimal intra-operative decision-making regarding the amount of tissue to be removed during surgery. Therefore, the field of pathology would be advanced – and positive surgical outcomes with reduced side effects would increase – if histopathological processes with reduced time scales were implemented.

Researchers at the University of California Davis have developed a label-free, spectral, pathology method that can quickly identify regions of diseased tissue in vivo without the need for traditional hematoxylin and eosin staining. A multimodal microscope capable of acquiring varied and simultaneous microscopy/spectroscopy images of unstained tissue can survey the tissue structure and architecture, and - by comparing unique tissue signatures provided by the microscope, discriminate between diseased and healthy cells. This method overcomes historical limitations associated with current approaches to intra-operative histopathology. 

Applications

•         Intraoperative pathology

Features/Benefits

Patent Status