Combined Individual Nanomaterial Enhancements for Total X-Ray Enhancement

Tech ID: 27601 / UC Case 2015-766-0


Researchers at the University of California, Davis have developed a method to combine individual nanomaterial enhancements to achieve greater X-ray enhancement.

Full Description

Nanomaterials have been used to enhance the effects of X-rays by either physical (increasing the absorption and the subsequent release of electrons from the material) or chemical (improving the catalytic functionality of gold nanoparticles driven by OH radicals produced by X-ray irradiation of water) means. Currently, there is no way to use the methods collectively and it is not known whether there is any advantage of using them together. Unless special care is given to isolate and maximize the enhancement, individual enhancements interfere with each other and create a total X-ray enhancement that is generally lower than the individual enhancement. Therefore, there is a need to develop methods to combine individual nanomaterial enhancements to produce higher total X-ray enhancement.

Researchers at the University of California, Davis have discovered a method to combine individual nanomaterial enhancements to create a higher total X-ray enhancement. When properly combined, the enhancements use less nanomaterial and allow for varied arrangements of nanomaterials at different locations. Multiple X-ray sources can potentially be used to achieve even greater X-ray enhancement. In cancer therapy the 100 keV X-ray source can be a source located outside the body and the low energy X-ray source can be a catheter planted near the cancer site. Both sources may deliver low doses of X-rays. Researchers were able to show that a mixture of physical and chemical enhancement to nanomaterials showed an 18.0-fold enhancement versus 5.5-fold and 2.0-fold enhancement individually. This means a lower radiation dose is required to achieve a similar effect and the arrangement allows for more focused radiation.


  • Improved total X-ray enhancement


  • Higher total X-ray enhancement
  • Lower required radiation dose
  • Greater x-ray radiation localization and efficiency
  • Less nanomaterial needed
  • Ability to re-arrange nanomaterial
  • Ability to use multiple X-ray sources

Patent Status

Country Type Number Dated Case
United States Of America Published Application 20180085731 03/29/2018 2015-766


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  • Guo, Ting

Other Information


nanomaterials, chemical, physical, synergy, radiation, radiation therapy, X-ray therapy, X-ray enhancement

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