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Preserving Protein Function Via Statistically Random Heteropolymers

Protein-based materials have the potential to change the current paradigm of materials science. However, it still remains a challenge to preserve protein hierarchical structure and function while making them readily processable. Protein structure is inherently fluid, and it is this property that contributes to their fragility outside of their native environment. Through the use of rationally designed statistically random heteropolymers, it is possible to stabilize proteins at each hierarchical level and process them in organic solvents, a common need for materials fabrication. The chemical and architectural complexities of statistically random heteropolymers provide a modular platform for tunable protein-polymer-solvent interactions. This provides opportunities not offered by small molecule surfactants or amphiphilic block copolymers. Through evaluation of horseradish peroxidase and green fluorescent protein structure, we show that statistically random heteropolymers can stabilize enzymes. Allowing for activity retention when stored in organic solvent, over 80% activity was observed after 24 hours. Furthermore, horseradish peroxidase and chymotrypsin proteins, when encapsulated in statistically random heteropolymers, are still accessible to their substrates while remaining inaccessible to the denaturing organic solvent. Statistically random heteropolymers have potential in creating stimuli-reponsive materials and nanoreactors composed of proteins and synthetic materials.

Deep Learning of Biomimetic Sensorimotor Control for Biomechanical Human Animation

UCLA researchers from the Department of Computer Science have developed a computer simulation model and associated software system for biomimetic human sensorimotor control.

A Wearable Platform for In-Situ Analysis of Hormones

UCLA researchers in the Department of Electrical and Computer Engineering have developed a highly sensitive, wearable hormone monitoring platform.

Soft Shear Force Resistive Sensor Embedded Artificial Skin

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a bioinspired, thin and flexible liquid metal filled resistive PDMS microchannel shear force sensing skin.

Conductive-Organometallic Framework

UCLA researchers in the Department of Chemistry have developed organic metallic framework (MOF) materials with high porosity and conductivity capabilities.

Plasma-Functionalized Bandpass Switch

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a device that combines the performance of a bandpass filter and gas-discharge switch into a single device.

In Situ Soil Nitrate Sensor

The invention is used for determining in-situ nitrate concentrations in soil solution using either ISE (Ion Selective Electrode) or fiber optic spectroscopy when the liquid in the porous cup of the in-situ probe is equilibrated with surrounding soil solution through the diffusion process.

Head-Mounted Display EEG Device

Diagnosis and detection of progression of neurological disorders remain challenging tasks. For example, a validated portable objective method for assessment of degenerative diseases would have numerous advantages compared to currently existing methods to assess functional loss in the disease. An objective EEG-based test would remove the subjectivity and decision-making involved when performing perimetry, potentially improving reliability of the test. A portable and objective test could be done quickly at home under unconstrained situations, decreasing the required number of office visits and the economic burden of the disease. In addition, a much larger number of tests could be obtained over time. This would greatly enhance the ability of separating true deterioration from measurement variability, potentially allowing more accurate and earlier detection of progression. In addition, more precise estimates of rates of progression could be obtained.

Variable Friction Shoe

The Variable Friction Shoe, which ameliorates the effects of drop foot.

Energy Radiator Using Strain-Mediated Spin Torque Nano-Oscillator (S-STNO)

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed an energy radiator based on a spin torque nano-oscillator that does not require the application of an external field.

Selective Deposition Of Diamond In Thermal Vias

UCLA researchers in the Department of Materials Science & Engineering have developed a new method of diamond deposition in integrated circuit vias for thermal dissipation.

Self-Locking Optoelectronic Tweezer And Its Fabrication

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel self-locking optoelectronic tweezer (SLOT) for single cell manipulation in conductive buffer over large areas.

Nanocellulose-Assisted Exfoliation of Graphite to Few Layer Graphene

Researchers at the University of California, Davis have developed a high-yield method that utilizes the unique properties of cellulose nanofibrils (CNFs) to fabricate high-quality graphene from bulk graphite. This graphene can then be fabricated into graphene nanopapers, which have unique moisture and heat-sensing capabilities for applications in “smart” electronic devices and other uses.

Flavonol Profile as a Sun Exposure Assessor for Grapes

Researchers at the University of California, Davis have developed a solar radiation assessment method for grapes that uses a flavonol profile. This method can be done using either HPLC or through the computer processing of the absorption spectra of a purified flavonol extract via a purification kit.

Non-Living Edible Surrogates For Process Validation Food Processing Plants

Researchers at the University of California, Davis have developed a surface sanitation validation system that utilizes a non-living edible surrogate to potentially help determine food processing efficacy.

Magnetoresistance Sensor With Perpendicular Anisotropy

UCLA researchers in the Department of Electrical Engineering have invented a novel magnetic sensor design that is highly sensitive and linear, with tunable response and low power consumption.

Stereo Image Acquisition By Lens Translation

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel single-objective lens stereo imaging setup for endoscopic applications.

Flexible Balloon-Inflatable Electrochemical Impedance Spectroscopy To Assess Endoluminal Lipid-Rich Lesions

UCLA researchers have developed a novel flexible balloon-inflatable electrochemical impedance spectroscopy to facilitate the diagnosis of metabolically active atherosclerotic lesions.

Automatic Fine-Grained Radio Map Construction and Adaptation

The real-time position and mobility of a user is key to providing personalized location-based services (LBSs) – such as navigation. With the pervasiveness of GPS-enabled mobile devices (MDs), LBSs in outdoor environments is common and effective. However, providing equivalent quality of LBSs using GPS in indoor environments can be problematic. The ubiquity of both WiFi in indoor environments and WiFi-enabled MDs, makes WiFi a promising alternative to GPS for indoor LBSs. The most promising approach to establishing a WiFi-based indoor positioning system requires the construction of a high quality radio map for an indoor environment. However, the conventional approach for making the radio map is labor intensive, time-consuming, and vulnerable to temporal and environmental dynamics. To address this situation, researchers at UC Berkeley developed an approach for automatic, fine-grained radio map construction and adaptation. The Berkeley technology works both (a) in free space – where people and robots can move freely (e.g. corridors and open office space); and (b) in constrained space – which is blocked or not readily accessible. In addition to its use with WiFi signals, this technology could also be used with other RF signals – for example, in densely populated and built-up urban areas where it can be suboptimal to only rely on GPS.

A Device, Methodology And System For Monitoring, Classifying And Encouraging Activity

UCLA researchers in the Department of Computer Science have developed a new technology to fight the growing obesity epidemic by encouraging exercise.

Actively Controlled Microarchitectures with Programmable Bulk Material Properties

Professor Jonathan Hopkins and colleagues have developed amechanical programmable metamaterial consisting of an array of actively, independently controlled micro-scale unit cells. This technology allows for the application of materials which have instantly changeable, programmable properties that can exceed those of conventional, existing materials.

Robust, Ultra-Flexible, Micro-Encoded Ferromagnetic Tape for Bioseparation and Assembly

Researchers at the UCLA Department of Bioengineering have developed methods to embed electroplated magnetic materials within elastomeric materials and use these flexible magnetic hybrid materials for biological applications.

ABSTRACT: Variable Gaseous Fuels Engine

Brief description not available

Conductive and Elastic Nanocellulose Aerogels

Researchers at the University of California, Davis have developed conductive nanocellulose aerogels as building blocks for mechanical strain sensors and coaxial aerogel fibers for cryo- and thermo-protective insulation.

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