UCLA researchers in the Department of Chemistry & Biochemistry have designed an improved version of trehalose-based glycopolymer as a degradable alternative to PEG for the purpose of stabilizing a protein during storage and transport.
A UCLA team led by Professor Heather Maynard has developed a family of polymers that effectively stabilizes industrial enzymes and therapeutic biologics and vaccines against thermal and mechanical stress while improving their in vivo pharmacokinetic properties. Widely-used polymers such as PEG do not effectively stabilize proteins against thermal and mechanical stress (necessitating special handling and storage conditions in supply chains).
The team has also developed a degradable polymer that is safely and effectively cleared in vivo. This may have benefits versus PEG especially in chronic use situations as PEG has been shown to induce formation of antibodies in 32–46% of patients as well as vacuolation in rodents upon injection with high molecular weight PEG. This degradable polymer may also have significant benefits in stabilizing industrial enzymes as it avoids unwanted environmental buildup and shows high stabilization of enzymes against thermal and mechanical stress.
The technology is based on a novel series of polymers that incorporate trehalose as a side chain. Trehalose is a disaccharide that is widely used by a variety of organisms to stabilize against environmental stressors such as a high temperatures, dessication, etc.
|United States Of America||Issued Patent||10,543,280||01/28/2020||2012-422|
|United States Of America||Issued Patent||10,273,333||04/30/2019||2015-602|
|United States Of America||Issued Patent||9901648||02/27/2018||2012-422|
|United States Of America||Published Application||20180312630||11/01/2018||2015-112|
|Patent Cooperation Treaty||Published Application||WO2019118202||06/20/2019||2012-422|
Additional Patents Pending
Trehalose glycopolymer, polymer, protein-polymer conjugates, polymer-drug conjugates, bioconjugates, degradable, protein stabilization, biomedical, drug delivery, therapeutics, environmental stressors