Minimally invasive glaucoma surgeries (MIGS), despite their favorable safety profile, cannot achieve the same intraocular pressure reduction as tube shunts or trabeculectomy. There is growing interest in targeting MIGS devices near functioning, large-caliber aqueous and episcleral veins, but methods to image these vessels in vivo are lacking. The present invention relates to the method for imaging episcleral vessels noninvasively and quantifying episcleral regional flow variation along the limbal circumference.
Researchers in UC Irvine’s Opthalmology department have established an ex-vivo system to image episcleral vessels and quantify the regional blood flow. Successfully identifying the collector channels in the trabecular meshwork (TM) may be crucial to achieve an effective MIGS. The previous studies that have been successfully imaged the TM outflow anatomy required excessive tissue processing which limited the clinical applicability.
The present invention utilized the confocal laser microendoscope to image both surface episcleral vessels and Schlemm’s canal through a scleral flap in ex vivo perfused eyes. Combining the microendoscope imaging and image analysis by using an algorithm, the episcleral vessel diameter and density could be acquired in real-time.
Researchers have successfully imaged episcleral vessels using this method in both human cadaver eyes and pig eyes.
The next development step is to perform the MIGS procedures based on the functional data obtained with this invention and see if targeting MIGS procedures to high flow (or low flow) area can lower intraocular pressure. We are currently looking for a commercial partner to further develop this invention.
|United States Of America||Published Application||20160262606||09/15/2016||2015-325|