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Antimicrobial and Osteoinductive Hydrogel for Dental Applications

UCLA researchers in the Department of Chemical & Biomolecular Engineering developed osteoinductive and antimicrobial hydrogel adhesives for dental applications.

Titanium Implants with Novel Roughness

UCLA researchers in the School of Dentistry at the Weintraub Center for Reconstructive Biology have developed a novel titanium implant with hierarchical multi-scale roughness to promote bone growth.

Vaccines Against Herpes Simplex Virus Infection

Herpes simplex virus (HSV) infections affect billions of patients worldwide and can manifest its symptoms as painful blisters or ulcers at oral, ocular or genital locations. Symptomatic patients can currently only alleviate their pains with antiviral medication. These technologies propose a shift in focus toward novel protective epitopes as the foundation for new vaccines.

BMP Binding Proteins and Prosthetic Surfaces

UCLA researchers have developed a method to attach and enhance the activity of bone growth factors to prostheses through BMP binding proteins to increase the integration of prostheses and bone.

BBP as a Complexed Carrier for Bone Growth Factors

UCLA researchers have identified a BMP binding peptide that binds to bone growth factors to increase their residence time at the site of implantation for treatment of bone defects.

Biomimetic Artificial Periodontal Membranes And Method Of Fabricating The Same

UCLA researchers in the Departments of Dentistry and Chemistry have developed a novel biomimetic and degradable periodontal polymer membrane for use in guided tissue regeneration.

Bioactive Adhesive Dental Restorative Cement

Researchers led by Alireza Moshaverinia from the School of Dentistry at UCLA have developed a novel restorative dental cement that promotes remineralization of damaged teeth.

Dental Adhesive Hydrogels And Uses Thereof

Researchers at the UCLA School of Dentistry and the Department of Chemistry & Biochemistry have developed novel biodegradable, photocurable, and non-toxic hydrogel-based adhesives, which can be used for periodontal tissue regeneration and personalized precision oral care.

An illuminated periodontal curette using wireless technologies for accurate perioscopy

The invention is an illuminated periodontal curette that offers an accurate and magnified visualization during complex dental procedures. The modified curette provides the operator with better real time insight and information regarding the tooth and root anatomy for accurate evaluation as well as procedure planning and therapy.

Vaccine Against Herpes Simplex Virus Infection

Herpes simplex virus (HSV) infections affect billions of patients worldwide and can manifest its symptoms as painful blisters or ulcers at oral, ocular or genital locations. Symptomatic patients can currently only alleviate their pains with antiviral medication. This technology proposes a shift in focus toward novel protective epitopes as the foundation for new vaccines.

Oral Microsensor Arrays for Remote Monitoring of Salivary Electrolytes for Precision Healthcare

UCLA researchers in the Department of Oral & Maxillofacial Surgery have developed a novel microsensor system for unobtrusive monitoring of oral pH and electrolytes levels. This system is integrated into a data analysis and feedback network for disease prevention and precision care.

Titanium Plates For Bone Regeneration

UCLA researchers in the School of Dentistry at the Weintraub Center for Reconstructive Biology have developed a new titanium plate to promote bone regeneration in dental reconstruction procedures.

High Frequency Digital Frequency Domain Fluorescence Lifetime Imaging System For Applications On Tissues

The technology is a software/hardware combination designed to enhance sampling rate for frequency domain fluorescence lifetime imaging. Fluorescence lifetime imaging microscopy (FLIM) is a technique that uses signals emitted from fluorescent samples to construct images of those samples in near real time. An advantage to FLIM is its ability to image large fields of view, which makes it an attractive option for dynamical measurements of live biological tissues. The higher sampling rate available using this technology will allow for more information to be gleaned from biological samples, which may have a fluorescence band up to 1 GHz, advancing tissue imaging.

Novel Anti-Bacterial, Anti-Fungal Nanopillared Surface

Medical devices are susceptible to contamination by harmful microbes, such as bacteria and fungi, which form biofilms on device surfaces. These biofilms are often resistant to antibiotics and other current treatments, resulting in over 2 million people per year suffering from diseases related to these contaminating microbes. Death rates for many of these diseases are high, often exceeding 50%. Researchers at UCI have developed a novel anti-bacterial and anti-fungal biocomposite that incorporates a nanopillared surface structure that can be applied as a coating to medical devices.

Sieve Container For Contactless Media Exchange For Cell Growth

Media that contains nutrients and growth factors is necessary to grow all types of cells, a process that is widely used in many fields of research. Such media should be routinely changed either to different media or a fresh batch of the same media. This change currently involves either using a pipette to transfer cells from their current dish of media to a new dish, or aspirating the media out of the dish and replacing it with new media. Both methods have inherent risks to stressing and damaging the cells. Researchers at UCI have developed a unique dish for growing cells that allows for safer aspiration of the old media, which reduces stress and damage to the cells.

A Micro/Nanobubble Oxygenated Solutions for Wound Healing and Tissue Preservation

Soft-tissue injuries and organ transplantation are common in modern combat scenarios. Organs and tissues harvested for transplantation need to be preserved during transport, which can be very difficult. Micro and nanobubbles (MNBs) offer a new technology that could supply oxygenation to such tissues prior to transplantation, thus affording better recovery and survival of patients. Described here is a novel device capable of producing MNB solutions that can be used to preserve viability and function of such organs/tissue. Additionally, these solutions may be used with negative pressure wound therapy to heal soft-tissue wounds.

Piezo Scaler With Laser Capabilities

A power driven ultrasonic dental device that utilizes laser light & sound to remove deposits from the teeth, reduce bacterial loads, and promote soft tissue healing while preventing disease transfer between the patient and physician.

Bioactive Dental Fillings to Induce Local Remineralization

Novel dental materials that stimulate in-situ biomimetic remineralization of the dentin layer by providing required ions and acidic polymers

A Fast-Setting Moisture-Tolerant Root Canal Retrofilling and Repair Material

Dr. Shane White and colleagues have developed a class of novel low-cost root repair materials that are biocompatible, easy to set and manipulate, have good abrasion resistance, and good dissolution resistance.

Method And Device For Dentistry

A technique to facilitate dental extraction, oral surgery, dental implant or specialized dentistry.

Knowledge Management Software

From Bauer et al. J. Calif Dent Assoc (2006): Clinical practice guidelines (CPGs) are statements developed from best evidence about clinically relevant appropriate care. These statements may be about protocols, standards or practice patterns. CPGs are important to the clinician to improve process and health outcomes whether they are created locally or nationally. CPGs organize and sequence care outcomes for specific conditions. Thus, the dentist uses the CPG to address specific and narrowly defined patient care issues. CPGs, have been shown to be effective in producing behavioral change in clinicians’ practices and care delivery.UCLA researchers have developed knowledge management software for use in managing and complying with CPGs.

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