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Processes For Microfluidic Fabrication

A method is provided to prepare one or more microfluidic channels on a receptive material by applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern and heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. In an alternative aspect, the microfluidic channels on receptive material are prepared by etching a designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%.

Preserving Protein Function Via Statistically Random Heteropolymers

Protein-based materials have the potential to change the current paradigm of materials science. However, it still remains a challenge to preserve protein hierarchical structure and function while making them readily processable. Protein structure is inherently fluid, and it is this property that contributes to their fragility outside of their native environment. Through the use of rationally designed statistically random heteropolymers, it is possible to stabilize proteins at each hierarchical level and process them in organic solvents, a common need for materials fabrication. The chemical and architectural complexities of statistically random heteropolymers provide a modular platform for tunable protein-polymer-solvent interactions. This provides opportunities not offered by small molecule surfactants or amphiphilic block copolymers. Through evaluation of horseradish peroxidase and green fluorescent protein structure, we show that statistically random heteropolymers can stabilize enzymes. Allowing for activity retention when stored in organic solvent, over 80% activity was observed after 24 hours. Furthermore, horseradish peroxidase and chymotrypsin proteins, when encapsulated in statistically random heteropolymers, are still accessible to their substrates while remaining inaccessible to the denaturing organic solvent. Statistically random heteropolymers have potential in creating stimuli-reponsive materials and nanoreactors composed of proteins and synthetic materials.

Athermal Nanophotonic Lasers

Researchers at the University of California, Davis have developed a nanolaser platform built from materials that do not exhibit optical gain.

Higher-Speed and More Energy-Efficient Signal Processing Platform for Neural Networks

Researchers at the University of California, Davis have developed a nanophotonic-based platform for signal processing and optical computing in algorithm-based neural networks that is faster and more energy-efficient than current technologies.

Shape-Controlled Particles Having Subparticle Geometrical Features

UCLA researchers in the Department of Chemistry and Biochemistry have developed a photolithographic method for the high-throughput, parallel production of microscale and nanoscale objects with tailored shapes and dimensions using a single photomask.

Hydrogel For Endogenous Neuronal Progenitor Cells (NPC) Recruitment

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a novel hydrogel that aids in neuronal regeneration post stroke or disease.

Micro- and Nanocomposite Support Structures for Reverse Osmosis Thin Film Membranes

UCLA researchers in the Department of Civil and Environmental Engineering have invented a novel nanofiltration (NF) and reverse osmosis (RO) composite membrane for water desalination applications.

Controlling Magnetization Using Patterned Electrodes on Piezoelectrics

UCLA researchers in the Department of Materials Science and Engineering have developed a novel piezoelectric thin film that can control magnetic properties of individual magnetic islands.

Multiple-Patterning Nanosphere Lithography

Researchers led by Paul Weiss from the Department of Chemistry and Biochemistry at UCLA have developed a novel technique that solves the scalability issue in the fabrication of three-dimensional nanostructures.

Methods And Devices for Continuous Analyte Sensing with Microporous Annealed Particle Gels

UCLA researchers in the Department of Bioengineering have developed novel microporous annealed particle gels for long-term continuous monitoring of blood metabolites.

High Stability PtNiX-M Electrochemical Catalyst

UCLA researchers in the Department of Material Science and Engineering have invented a novel and highly stable platinum-based catalyst material for fuel cell technologies.

Half-Virtual-Half-Physical Microactuator

Researchers at the University of California, Davis have developed a half-virtual-half-physical microactuator that utilizes a combination of computational models and microelectromechanical systems for use in medical devices and mechanical systems.

Anti-Ferromagnetic Magneto-Electric Spin-Orbit Read Logic

UCLA researchers in the department of Electrical Engineering have developed a novel magetoelectric device for use as a spin transistor.

Mobile Phone Based Fluorescence Multi-Well Plate Reader

UCLA researchers have developed a novel mobile phone-based fluorescence multi-well plate reader.

Diels-Alder Chemistry for Bioconjugation and Incorporation into Non-Natural Amino Acids

A bioconjugation method to covalently link molecular entities to polypeptides such as antibodies using a simple one-pot process.

Active Nanoplatform with High Drug Loading Capacity for the Diagnosis and Treatment of Cancer

Researchers at the University of California, Davis have developed an active nanoplatform (F/HAPIN) for cancer diagnosis and therapy.

Novel Anti-Bacterial, Anti-Fungal Nanopillared Surface

Medical devices are susceptible to contamination by harmful microbes, such as bacteria and fungi, which form biofilms on device surfaces. These biofilms are often resistant to antibiotics and other current treatments, resulting in over 2 million people per year suffering from diseases related to these contaminating microbes. Death rates for many of these diseases are high, often exceeding 50%. Researchers at UCI have developed a novel anti-bacterial and anti-fungal biocomposite that incorporates a nanopillared surface structure that can be applied as a coating to medical devices.

Biologically Applicable Water-Soluble Heterogeneous Catalysts For Parahydrogen-Induced Polarization

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method of parahydrogen-induced polarization in water using heterogeneous catalysts.

Rapid, Portable And Cost-Effective Yeast Cell Viability And Concentration Analysis Using Lensfree On-Chip Microscopy And Machine Learning

UCLA researchers in the Department of Electrical Engineering have developed a new portable device to rapidly measure yeast cell viability and concentration using a lab-on-chip design.

Process For Recycling Surfactant In Nanoemulsion Production

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method to separate and recycle surfactants used in the manufacturing of nanoemulsions.

Mechanical Process For Creating Particles Using Two Plates

UCLA researchers in the Department of Chemistry and Biochemistry & Physics and Astronomy have developed a novel method to lithograph two polished solid surfaces by using a simple mechanical alignment jig with piezoelectric control and a method of pressing them together and solidifying a material.

A General Method For Designing Self-Assembling Protein Nanomaterials

UCLA researchers in the Department of Chemistry & Biochemistry have developed a novel computational method for designing proteins that self-assemble to a desired symmetric architecture. This method combines symmetrical docking with interface design, and it can be used to design a wide variety of self-assembling protein nanomaterials. 

Oil-in-Water-in-Oil Multinanoemulsions for Templating Complex Nanoparticles

A process of creating multinanoemulsions using sequential high-energy emulsification.

Tunable Thz Generation In Chip-Scale Graphene

UCLA researchers in the Department of Electrical Engineering have developed a novel tunable and efficient terahertz (THz) plasmon generation on-chip via graphene monolayers.

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