FRET-Cal Screening Platform for Membrane Signaling Protein Modulators

Patent Status

Patent Pending

Brief Description

This invention developed by UC Berkeley researchers provides a novel FRET-Cal Screening Platform to identify positive and negative modulators of membrane signaling proteins. The platform addresses the need for efficient and reliable methods to screen for compounds that can control the activity of these receptors. The technology utilizes a receptor protein with a Förster resonance energy transfer (FRET) pair, composed of a donor and acceptor fluorophore, to screen for candidate compounds. The FRET pair allows for the direct measurement of changes in protein conformation upon binding, providing a highly sensitive and specific method for identifying potential modulators. This platform offers a significant advantage over traditional screening methods by providing a high-throughput, real-time assay for drug discovery and therapeutic development.

Suggested uses

Advantages

Related Materials