Researchers at UCLA from the Departments of Medicine and Bioengineering have created a device that modulates the autonomic nervous system to treat heart conditions like arrhythmias.
The autonomic nervous system controls unconscious bodily functions like breathing and maintaining heart function. The cardiac autonomic nervous system includes the Vagus nerve and intrinsic cardiac nervous system. Modulating this system can provide therapeutic effects such as preventing cardiac arrhythmias (improper beating of the heart). Currently, pharmacological treatments, ablation therapies, and cardioversion (defibrillation) are used to treat arrhythmias like atrial fibrillation. Drug treatments have side effects (e.g. nausea, breathing problems) and can build a tolerance over time. Ablation and cardioversion usually require repeat procedures, can potentially lead to further complications like stroke, and still requires the use of medication after the procedure. Modulation of the autonomic nervous system provides a new avenue to treat heart conditions in patients where current treatments do not work.
Researchers from the Departments of Medicine and Bioengineering have created a device that modulates the autonomic nervous system to treat heart conditions like arrhythmias. The device electrically stimulates the Vagus nerve to control heart function. In a canine study, stimulation of the Vagus nerve either prevented atrial fibrillation or dampened its effect 75% of the time and prevented further arrhythmias by reorganizing the autonomic nervous system. This success rate is comparable to the high success rate of ablation therapies, but without the side effects or the need for subsequent medication. This strategy has also been shown to work in other cardiac complications. In a guinea pig study, vagal nerve stimulation prevented maladaptive changes in cardiac structure and function seen after chronically overloading the heart.
Heart, Cardiovascular, bioelectronics, electroceutical, circulation, arrhythmia, vagus nerve, neuromodulation, neurostimulation, autonomic nervous system, heart attack, medical devices, heart disease, implantable devices