These transgenic mice express an inducible version of cre recombinase mice under the direction of a Sox9 promoter. They are suitable for performing cre-recombination in pancreatic ductal cells and their progenitors.
Mice hemizygous for the BAC Sox9-creERT2 transgene are viable and fertile. Cre-ERT2 expression is directed by the murine SRY-box containing gene 9 (Sox9) promoter/enhancer regions in early pancreatic progenitor and ductal cells. Restricted to the cytoplasm, Cre-ERT2 can only gain access to the nuclear compartment after exposure to tamoxifen. When these mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in the cre-expressing cells of the offspring.
Applications include the following:
The mice are designated Tangible Research Material (TRM). A complete description, including genotyping, phenotyping, etc is found at The Jackson Lab cat. No. 018829 https://www.jax.org/strain/018829
Academic and non-profit institutions please order directly from The Jackson Laboratory. Commercial entities require a license from UC San Diego contact ( https://innovation.ucsd.edu/contact/).
Bacterial artificial chromosome, Sox9, CRE recombinase, transgene, pancreas, transgenic mice