TRM:Sox9CreER BAC Transgenic Mice

Tech ID: 30492 / UC Case 2010-132-0


These transgenic mice express an inducible version of cre recombinase mice under the direction of a Sox9 promoter. They are suitable for performing cre-recombination in pancreatic ductal cells and their progenitors.

Technology Description

Mice hemizygous for the BAC Sox9-creERT2 transgene are viable and fertile. Cre-ERT2 expression is directed by the murine SRY-box containing gene 9 (Sox9) promoter/enhancer regions in early pancreatic progenitor and ductal cells. Restricted to the cytoplasm, Cre-ERT2 can only gain access to the nuclear compartment after exposure to tamoxifen. When these mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in the cre-expressing cells of the offspring. 


Applications include the following:

  • Research Tools
  • Genetics Research
  • Tissue/Cell Markers: pancreatic beta cells
  • Cre-lox System
  • Cre Recombinase Expression: Inducible

State Of Development

 The mice are designated Tangible Research Material (TRM).  A complete description, including genotyping, phenotyping, etc is found at The Jackson Lab cat. No. 018829

Intellectual Property Info

Academic and non-profit institutions please order directly from The Jackson Laboratory. Commercial entities require a license from UC San Diego contact (

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Other Information


Bacterial artificial chromosome, Sox9, CRE recombinase, transgene, pancreas, transgenic mice

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