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(SD2022-275) Methods and compositions governing the use of proteins and protein domains that enhance exon inclusion
The strategy employed by the invention is inspired by splicing factors, a category of RNA-binding protein that influence alternative splicing outcomes. These splicing factors are trans-acting, and act to enhance or silence exon inclusion by binding near or on the target exon and promoting or repressing the activity of splicing machinery. Scientifically, a highly programmable, minimally disruptive system to increase exon inclusion could allow for higher-throughput identification of functional roles of specific exons than have been previously shown.
(SD2024-124) Predicting neural activity at depth from surface using multimodal experiments and machine learning models
Researchers from UC San Diego's Neuroelectronic Lab (https://neuroelectronics.ucsd.edu/) demonstrate that they can predict neural activity at deeper layers of the brain by only recording potentials from brain surface. This was achieved by performing multimodal experiments with an ultra-high density transparent graphene electrode technology and developing neural network methods to learn nonlinear dynamic between different modalities. They used cross modality inference to predict the activity at deep layers from surface. Prediction of neural activity at depth have the potential to open up new possibilities for developing minimally invasive neural prosthetics or targeted treatments for various neurological disorders.
(SD2022-177 ) Flexible, insertable and transparent microelectrode array to detect interactions between different brain regions
Researchers from UC San Diego's Neuroelectronics Lab invented an implantable brain electrode technology which allows recording interactions between different cortex regions or interactions of cortex with other subcortical structures. The technology is called Neuro‐FITM. Flexibility and transparency of Neuro‐ FITM allow integration of electrophysiological recordings with any optical imaging (such as high resolution multiphoton imaging) or stimulation technology (such as optogenetics).
(SD2022-066) Simultaneous assessment of afferent and efferent visual pathways using multi‐focal steady‐state visual evoked potenital method to facilitate the diagnosis and prognosis of individuals with neurological diseases.
Researchers from UC San Diego have developed a patent-pending wearable device for concurrently assessing afferent and efferent visual functions. The invention details novel mobile brain-computer interfacing methods and systems for concurrently assessing afferent and efferent visual functions.
(SD2024-136) A Gravitationally Resilient Automated Molecular Biology Platform
A patent-pending platform technology designed to work in any gravity, which includes in microgravity environments, able to execute advanced molecular biology workflows; representing a paradigm shift in automation for molecular biology.
(SD2023-232) Multi-Dimensional Widefield Infrared-encoding Spontaneous Emission Microscopy
Hyperspectral imaging (HSI) is an emerging imaging modality for medical applications, especially in disease diagnosis and image-guided surgery. HSI acquires a three-dimensional dataset called hypercube, with two spatial dimensions and one spectral dimension. Spatially resolved spectral imaging obtained by HSI provides diagnostic information about the tissue physiology, morphology, and composition. Researchers from UC San Diego developed a new method using a pair of femtosecond mid-infrared and visible excitation pulses to distinguish chromophores, including molecules and quantum dots, that possess nearly identical emission spectra using multiplexed conditions in a three-dimensional space.
(SD2018-040) High Yield Fabrication of Sharp Vertically Aligned Nanowire Arrays for Intracellular Recordings and Applications Thereof
Engineers from UC San Diego have disclosed a new patent-pending technology (SHARP, VERTICALLY ALIGNED NANOWIRE ELECTRODE ARRAYS, HIGH-YIELD FABRICATION ANDINTRACELLULAR RECORDING) that minimizes the electrode size to an intracellular probe, and is scalable to integrate multiple channels at one platform and overcomes the previous disadvantages such as invasiveness and insensitivity. This newly disclosed improved technology reduces the number of steps and the number of metal layers used to increase the biocompatibility and device yield, as compared to an earlier disclosure for NEAs that were fabricated using a different process.
(SD2021-427) Upregulation of cellular proteins using coronavirus-derived protein/peptides fused to RNA-targeting effectors
Researchers from UC San Diego developed an invention that enables protein expression to be upregulated using specific proteins and/or peptide sequences derived from SARS-CoV-2 proteins that are engineered to recognize specific mRNA transcripts by fusion to RNA-targeting modules such as CRISPR/Cas systems. They anticipate that these proteins can be fused or tethered to any engineered RNA-targeting moiety/module such as PUF/Pum, and pentatricopeptide proteins.