UCLA researchers in the Department of Medicine have developed a novel intravascular ultrasound-guided electrochemical impedance spectroscopy (IVUS-EIS) system for the detection of oxLDL-laden plaques in arteries.
Carotid artery disease refers to the narrowing of the carotid arteries which occurs due to the buildup of fatty substances and cholesterol deposits known as plaques. Blocked carotid arteries significantly increase the risk of stroke as blood flow to the brain can be interrupted. Current methods of determining if a patient has carotid artery disease include Doppler ultrasound, ankle-brachial index, and ECG. The drawback to these methods is that they only provide structural information, whereas electrical and chemical information would be extremely useful in obtaining measurements of the plaques.
Researchers at UCLA have developed an intravascular ultrasound-guided electrochemical impedance spectroscopy sensor to enhance the detection reproducibility of plaques. The oxidation of low-density lipoproteins (oxLDL) has been found to play a pathogenic role in plaque formation. The level of oxLDL in plaques is significantly higher compared to circulating levels. This invention has been demonstrated to detect intraplaque oxLDL with reduced standard deviation and increased statistical significance in both impedance and phase delay.
Development is ongoing. A prototype has been successfully tested in both animal models and human explant models.
|United States Of America||Published Application||20190183392||06/20/2019||2016-589|
|European Patent Office||Published Application||3454755||03/20/2019||2016-589|
Cardiac, ultrasonic transducer, flexible 2-point electrodes, electrochemical impedance spectroscopy, dual sensor-based intravascular catheter, plaque assessment