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A Highly Error-Prone Orthogonal Replication System For Targeted Continuous Evolution In Vivo

Inventors at UC Irvine have engineered an orthogonal DNA replication system capable of rapid, accelerated continuous evolution. This system enables the directed evolution of specific biomolecules towards user-defined functions and is applicable to problems of protein, enzyme, and metabolic pathway engineering.

High Performance Transition-Metal Doped PtNi Catalysts

Researchers at UCLA have developed a novel doped platinum-nickel catalyst that has demonstrated record specific activities and mass activity that are orders of magnitude higher than that of commercially available advanced platinum-based catalyst.

Synthesis Of Graphene Nanoribbons From Monomeric Molecular Precursors Bearing Reactive Alkyne Units

Researchers in the Department of Chemistry and Biochemistry have developed a novel graphene nanoribbon synthesis, which have numerous applications in electronic devices.

Diels-Alder Chemistry for Bioconjugation and Incorporation into Non-Natural Amino Acids

A bioconjugation method to covalently link molecular entities to polypeptides such as antibodies using a simple one-pot process.

Hydrogen Gas Sensors Based On Patterned Carbon Nanotube Ropes

This is a fabrication method for hydrogen gas sensors; these sensors have more rapid response times and are more sensitive than current detection techniques.

Hydrocarbon Production, H2 Evolution And CO2 Conversion By Whole Cells Or Engineered Azotobacter Vinelandii Strains

Using metal catalysts in industrial synthesis of hydrocarbons for fuels can be costly, inefficient, and harmful to the environment. This simple approach uses genetically-modified soil bacterium to synthesize valuable hydrocarbons using recycled components. This novel process is environmentally-friendly and is more cost- and energy-efficient than current industrial synthesis.

Simple Method For Dc Capillary Electrophoresis

Researchers at the University of California, Santa Barbara have developed a microchannel geometry that observes and measures the motion of charged particles that enable one to perform simple DC electrophoresis to measure the electrophoretic mobility of analytes and particles.

Chemical Synthesis of Lipid Mediator 22-HDoHE and Structural Analogs

Researchers at the University of California, Davis have developed an efficient method to chemically synthesize the endogenous lipid mediator, 22-hydroxydocosahexaenoic acid (22-HDoHE) which can be applied to related natural mediators and analogs.

Butadiene Sulfone (BDS) as a Green Multi-Functional Telomerization Agent for Tunable Hydrophobic Nanocellulose

Researchers at the University of California, Davis have developed a green method green for the telomerization of cellulose using BDS as a multi-functional reagent, solvent and acid source.

Biologically Applicable Water-Soluble Heterogeneous Catalysts For Parahydrogen-Induced Polarization

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method of parahydrogen-induced polarization in water using heterogeneous catalysts.

Determination Of Absolute Configuration Of Secondary Alcohols Using A Competing Enantioselective Conversion Kit

The absolute configuration of an organic compound dictates its interactions with other chemicals. The Competing Enantioselective Conversion (CEC) method is an attractive method for determining the absolute configuration of secondary alcohols, but the preparation of stock reagent solutions takes longer than the analysis time itself – a mere 1-2 hours. The inventors at UCI have developed a CEC kit which contains stock solutions of the components required for CEC that remain stable and usable for several months.

Functionalized Polypeptides by Alkylation of Thioether Groups via Ring Opening Reactions

UCLA researchers in the Department of Bioengineering have developed a simple approach to modify polypeptides and proteins.

Compound Library Made Through Phosphine-Catalyzed Annulation/Tebbe/Diels-Alder Reaction

UCLA researchers in the Department of Chemistry and Biochemistry have developed a small molecule library consisting of a large variety stereochemical variants.

Update To Degradable Trehalose Glycopolymers

UCLA researchers in the Department of Chemistry & Biochemistry have designed an improved version of trehalose-based glycopolymer as a degradable alternative to PEG for the purpose of stabilizing a protein during storage and transport.

Renewable Energy Synthesis System

Researchers at the University of California, Davis have developed a novel system for acetoin and 2,3-butanediol synthesis from carbon dioxide.

Metal-free affinity media/agents for the selective capture of histidine-rich peptide sequences

The present invention utilizes metal-free synthetic polymer-based materials for the purification of peptides and proteins containing or being fused with histidine-rich sequences, which does not damage the function of the target protein and is less costly.

Next-generation broad-spectrum anti-cancer Rad51 inhibitors

This invention describes the design, synthesis and successful evaluation of a panel of novel Rad51 inhibitors to treat a broad spectrum of cancer types.

Utilization Of Recombinant Glucosyltransferases For Value-Added Chemicals

96 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Glycoyltransferases are a large class of enzymes that act to catalyze the ligation of sugar onto an acceptor molecule – a process termed glycosylation. Within plants, a majority of these enzymes are involved in adding sugar groups to small molecules, forming “glycosides”. Such a modification can heavily impact the bioactivity, solubility, and physical properties of a molecule. Previous researchers have shown direct microbial bioconversion of aromatic/aliphatic flavor and fragrant molecules into their glucosides via glycosyltransferase activity via either feeding/bioconversion or direct production from glucose. However, very little emphasis has been placed on industrial yeast-­based production of specialist fragrances/flavorings or medicinal drugs.   Researchers at the University of California, Berkeley have developed a novel technology for producing plant pigment glucosides (such as highly decorated anthocyanins, coumarin glucosides, or betanins) in S. cerevisiae for industrial fermentation. Production of such colorimetric glycoside agents has value for various industries including solar-­cell, diagnostic reagent, and food-­dye manufacturers.  The technology can be used to improve the titers of commodity chemicals or the properties of various specialty or medicinal compounds. The technology also addresses one possible solution to combating the contamination of industrial fermenters through providing a method of enabling the utilization of broad-spectrum antimicrobial agents without harming the production host and as one facet of improving microbial tolerance to lignocellulose hydrolysate phenolics.  

Rapid And Selective Cycloaddition Reaction For Applications In Molecular Imaging

UCLA researchers in the Department of Molecular and Medical Pharmacology, and Department of Chemistry and Biochemistry have designed a new reaction with 18F-chemistry platform, allowing a highly selective, efficient and rapid approach to label biomolecules with a chemical reporter (i.e. radionuclide, fluorescent dye) for molecular imaging.

Enhanced Cell/Bead Encapsulation Via Acoustic Focusing

The invention consists of a multi-channel, droplet-generating microfluidic device with a strategically placed feature. The feature vibrates in order to counteract particle-trapping micro-vortices formed in the device. Counteracting these vortices allows for single particle encapsulation in the droplets formed by the device and makes this technology a good candidate for use in single cell diagnostics and drug delivery systems.

Sensitive Detection Of Chemical Species Using A Bacterial Display Sandwich Assay

96 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:Calibri; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Endocrine disrupting compounds are found in increasing amounts in our environment, originating from pesticides, plasticizers, and pharmaceuticals, among other sources. These compounds have been implicated in diseases such as obesity, diabetes, and cancer. The list of chemicals that disrupt normal hormone function is growing at an alarming rate, making it crucially important to find sources of contamination and identify new compounds that display this ability. However, there is currently no broad-spectrum, rapid test for these compounds, as they are difficult to monitor because of their high potency and chemical dissimilarity.   To address this, UC Berkeley researchers have developed a new detection system and method for the sensitive detection of trace compounds using electrochemical methods.  This platform is both fast and portable, and it requires no specialized skills to perform. This system enables both the detection of many detrimental compounds and signal amplification from impedance measurements due to the binding of bacteria to a modified electrode. The researchers were able to test the system finding sub-ppb levels of estradiol and ppm levels of bisphenol A in complex solutions. This approach should be broadly applicable to the detection of chemically diverse classes of compounds that bind to a single receptor.  

Novel Metal Organic Frameworks with Superior Physical Properties

While there is a huge existing field of metal organic framework (MOF) and coordination polymer (CP) materials, there are essentially zero crystalline systems which allow for zero-valent metals to be present as the primary structural building unit. Most MOFs and CPs utilize anionic ligands and metal centers in an oxidized state. This forms the basis of strong ‘reticular’ bonds which impart both stability and, in the case of MOFs, permanent porosity on these solid state materials. The fact that metals in MOFs or CPs are oxidized, does not allow for reactivity or chemistry that is known for zero-valent metals. To stabilize zero-valent metals in a MOF or CP, this invention uses multi-topic isocyanide ligands, which form bonds to both low (and zero) valent metal centers as well as metal centers in higher oxidation states. The ability to stabilize many metal oxidation states is a hallmark of isocyanide coordination chemistry. In addition, the ability of isocyanides to participate simultaneously as s donors and p acceptors allows them to form one of the strongest metal ligand bonds.

Voltage-Sensitive Dyes In Living Cells

96 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:Calibri; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Comprehensively mapping and recording the electrical inputs and outputs of multiple neurons simultaneously with cellular spatial resolution and millisecond time resolution remains an outstanding challenge in the field of neurobiology. Traditionally, electrophysiology is used to directly measure membrane potential changes. While this technique yields sensitive results, it is invasive and only permits single-cell recording.  VoltageFluor dyes rely on photoinduced electron transfer to effectively report membrane potential changes in cells. This approach allows for fast, sensitive and non-invasive recording of neuronal activity in cultured mammalian neurons and in ex-vivo tissue slices. However, one major limitation of small-molecule dye imaging is the inability to target the dye to specific cells of interest.   UC Berkeley researchers have developed latent voltage sensitive dyes that require a fluorogenic activation step. This new class of VoltageFluor dyes are only weakly fluorescent until being activated in defined cell types via biological processes. In particular, the VoltageFluor dyes described herein comprise a bioreversible group that quenches the fluorescence of the VoltageFluor dye, that upon selective removal by the action of biological processes (e.g., enzymes) thereby activates the fluorescence of the VoltageFluor dye. The researchers found that the new dye facilitated the observation of spontaneous activity in rat hippocampal neurons.  

Production of Glycolipid PEFAs from Yeasts

Method of using basidiomycetous yeasts to convert carbohydrates to glycolipid biosurfactants

Second Method For Nucleophilic Fluorination Of Aromatic Compounds With No-Carrier-Added [F-18] Fluoride Ion

UCLA researchers in the Department of Pharmacology have developed a novel aromatic nucleophilic fluorination reaction producing Fluorine-18 [F-18]-labeled aromatic compounds with extensive use in Positron Emission Tomography (PET).

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