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Gold Catalyzed Hydroamination of Alkynes and Allenes

Researchers at the University of California, Riverside have developed a gold complex that functions as the catalyst used in hydroamination of alkynes and allenes. The catalyst has many forms, such as gold nanoparticles/clusters and gold compounds combined with the salts of other metals. Typically, the catalyst has the following structure: L1 – Au+ - L2. L1 and L2 are unique ligands. The catalyst is robust enough to allow hydroamination at a wide range of temperatures (0˚C - 300˚C). Depending on the starting material/catalyst used, 100% hydroamination is achieved in 6 to 24 hours. Fig. 1 One of the catalytic gold complex catalysts used for hydroamination. Note the presence of the ammonia (NH3) as one of the two ligands. Fig. 2 Examples of catalytic amination of various alkynes with ammonia. The last four compounds are dialkynes, which contain multiple carbon-carbon double bonds. Hydroamination of these compounds leads to the formation of heterocyclic rings.  

Inhibition of Pyruvate Oxidation to Promote Hair Growth

UCLA researchers in the departments of Molecular, Cell & Developmental Biology and Biological Chemistry have elucidated a novel mechanism by which pyruvate oxidation can be inhibited in order to promote hair growth.

Methods for Enhancing Cell Populations for Articular Cartilage Repair

Cartilage lesion treatments require expanding cells from healthy donor cartilage which have limited availability and restricted potential to produce cartilage. This invention overcomes these challenges, presenting chemical and physical methods for enhancing cell populations capable of producing neocartilage. According to a 2015 global market report, tissue engineering technologies are expected to reach over 94B USD by 2022.

Methods for Producing Neocartilage with Functional Potential

Cell expansion for cartilage tissue production usually leads to loss of the potential to produce cartilage, which impedes uses for cartilage repair. This invention features methods and systems for producing highly expanded primary cells to construct functional neocartilage and other neotissue. According to a 2015 global market report, tissue engineering technologies are expected to reach over 94B USD by 2022.

Photo-Rechargeable Antibacterial/Antiviral Materials

Researchers at the University of California, Davis have developed a method to incorporate and enhance photo-induced biocidal functions on compounds, polymers, fibers, films, and textiles for daylight-driven rechargeable antibacterial and antivirus applications such as personal protective clothing, food packaging materials and medical devices.

Nontoxic Alternatives to Phthalate Plasticizers for PVC

Phthalates are synthetic chemicals added to polyvinyl chloride (PVC) to make flexible plastics. Due to health concerns, phthalates have been banned from children's products in the United States and Europe, but they are still used in a wide range of consumer products, including food wrap, medical devices, automotive parts, and building materials., chemicals that interfere with the body's hormone systems. Effects on wildlife of phthalates in the environment are also a concern. Phthalates are readily absorbed by the body through inhalation, ingestion, or skin contact. Phthalate exposure has been associated with reproductive and developmental abnormalities in animal studies. Epidemiological studies in humans also suggest that exposure to phthalates may have adverse health effects, including reproductive abnormalities that can lead to infertility. Phthalates are metabolized by the body into compounds that are considered endocrine disruptors. Because phthalates are not chemically bound to the PVC polymer, they tend to migrate out of plastic products and into the environment. The same is true of alternative plasticizers currently on the market. Dr. Rebecca Braslau’s laboratory has developed an approach to use compounds to replace phthalates that can be chemically attached to the PVC polymer chain: “internal plasticizers.”    

A Highly Error-Prone Orthogonal Replication System For Targeted Continuous Evolution In Vivo

Inventors at UC Irvine have engineered an orthogonal DNA replication system capable of rapid, accelerated continuous evolution. This system enables the directed evolution of specific biomolecules towards user-defined functions and is applicable to problems of protein, enzyme, and metabolic pathway engineering.

High Performance Transition-Metal Doped PtNi Catalysts

Researchers at UCLA have developed a novel doped platinum-nickel catalyst that has demonstrated record specific activities and mass activity that are orders of magnitude higher than that of commercially available advanced platinum-based catalyst.

Synthesis Of Graphene Nanoribbons From Monomeric Molecular Precursors Bearing Reactive Alkyne Units

Researchers in the Department of Chemistry and Biochemistry have developed a novel graphene nanoribbon synthesis, which have numerous applications in electronic devices.

Diels-Alder Chemistry for Bioconjugation and Incorporation into Non-Natural Amino Acids

A bioconjugation method to covalently link molecular entities to polypeptides such as antibodies using a simple one-pot process.

Hydrogen Gas Sensors Based On Patterned Carbon Nanotube Ropes

This is a fabrication method for hydrogen gas sensors; these sensors have more rapid response times and are more sensitive than current detection techniques.

Hydrocarbon Production, H2 Evolution And CO2 Conversion By Whole Cells Or Engineered Azotobacter Vinelandii Strains

Using metal catalysts in industrial synthesis of hydrocarbons for fuels can be costly, inefficient, and harmful to the environment. This simple approach uses genetically-modified soil bacterium to synthesize valuable hydrocarbons using recycled components. This novel process is environmentally-friendly and is more cost- and energy-efficient than current industrial synthesis.

Simple Method For Dc Capillary Electrophoresis

Researchers at the University of California, Santa Barbara have developed a microchannel geometry that observes and measures the motion of charged particles that enable one to perform simple DC electrophoresis to measure the electrophoretic mobility of analytes and particles.

Selective Transfer Of A Thin Pattern From Layered Material Using A Patterned Handle

Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; mso-fareast-language:JA;} Van der Waals crystals are a class of materials composed of stacked layers. Individual layers are single- or few-atoms thick and exhibit unique mechanical, electrical, and optical properties, and are thus expected to see widespread adoption in devices across a range of fields such as optical, electronic, sensing, and biomedical devices.  Graphene and transition metal dichalcogenides offer desirable properties as few-layer or monolayer film. Accessing the monolayer form in a repeatable fashion, as part of a predictable and high-yield manufacturing process is critical to realizing the many potential applications of two-dimensional materials at scale. In order to fabricate devices made from few- or monolayer materials, layer(s) of material of specified size and shape, arranged in a pre-determined pattern, must be deposited on a desired substrate and conventional transfer methods include pressure-sensitive adhesives and other viscoelastic polymers and require applied pressure to adhere to their target which can cause out-of-plane deformations and problems with isolating and transferring the patterned few- or monolayer material. Deep etching has similar drawbacks.   UC Berkeley researchers have discovered methods and compositions that enable the transfer medium to adhere strictly to patterned regions, allowing the transfer to remove only patterned material and leave behind unpatterned bulk. This method involves the creation of an intermediate layer between the source material and the transfer medium. Because this layer must strictly cover patterned material, it serves as an etch mask for isolating few-layer material in the desired pattern. Any material which is microns-thick, patternable at the desired lateral pattern scale (likely micron-scale), and subsequently removable would make a suitable intermediate layer. 

Chemical Synthesis of Lipid Mediator 22-HDoHE and Structural Analogs

Researchers at the University of California, Davis have developed an efficient method to chemically synthesize the endogenous lipid mediator, 22-hydroxydocosahexaenoic acid (22-HDoHE) which can be applied to related natural mediators and analogs.

Butadiene Sulfone (BDS) as a Green Multi-Functional Telomerization Agent for Tunable Hydrophobic Nanocellulose

Researchers at the University of California, Davis have developed a green method green for the telomerization of cellulose using BDS as a multi-functional reagent, solvent and acid source.

Xanthene-Based Dyes For Voltage Imaging

Rapid changes in the membrane potential of excitable cells (e.g., neurons and cardiomyocytes) play a central role in defining the cellular signaling and physiological profiles of these specialized cells. Typically, the membrane potential is monitored and measured via patch clamp electrophysiology, which involves the use of a micro-electrode attached to or near the cell of interests.  Unfortunately, the use of an electrode is highly invasive, limits records to the soma of a single cell and is extremely low throughput. Researchers at the University of California, Berkeley have designed and synthesized a voltage sensitive indicator that can provide excitation and emission profiles greater than 700 nm, and as such, represents an important method for visualizing membrane potential in living cells.

Biologically Applicable Water-Soluble Heterogeneous Catalysts For Parahydrogen-Induced Polarization

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method of parahydrogen-induced polarization in water using heterogeneous catalysts.

Determination Of Absolute Configuration Of Secondary Alcohols Using A Competing Enantioselective Conversion Kit

The absolute configuration of an organic compound dictates its interactions with other chemicals. The Competing Enantioselective Conversion (CEC) method is an attractive method for determining the absolute configuration of secondary alcohols, but the preparation of stock reagent solutions takes longer than the analysis time itself – a mere 1-2 hours. The inventors at UCI have developed a CEC kit which contains stock solutions of the components required for CEC that remain stable and usable for several months.

Functionalized Polypeptides by Alkylation of Thioether Groups via Ring Opening Reactions

UCLA researchers in the Department of Bioengineering have developed a simple approach to modify polypeptides and proteins.

Compound Library Made Through Phosphine-Catalyzed Annulation/Tebbe/Diels-Alder Reaction

UCLA researchers in the Department of Chemistry and Biochemistry have developed a small molecule library consisting of a large variety stereochemical variants.

Update To Degradable Trehalose Glycopolymers

UCLA researchers in the Department of Chemistry & Biochemistry have designed an improved version of trehalose-based glycopolymer as a degradable alternative to PEG for the purpose of stabilizing a protein during storage and transport.

Au(III) Complexes For [18F] Trifluoromethylation

96 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} The biological properties of trifluoromethyl compounds (e.g, CF3) have led to their ubiquity in pharmaceuticals, yet their chemical properties have made their preparation a substantial challenge, necessitating innovative chemical solutions.  For example, strong, non-interacting C-F bonds lend metabolic stability while simultaneously limiting the ability of chemical transformations to forge the relevant linkages and install the CF3 unit.  When these same synthetic considerations are extended toward the synthesis of trifluoromethylated positron emission tomography (PET) tracers, the situation becomes more complex.   UC Berkeley researchers discovered an unusual alternative mechanism, in which borane abstracts fluoride from the CF3 group in a gold complex. The activated CF2 fragment can then bond to a wide variety of other carbon substituents added to the same gold center. Return of the fluoride liberates a trifluoromethylated compound from the metal. This mechanism would be useful for the introduction of radioactive fluoride substituents for potential tracers to be used for positron emission tomography applications.

Renewable Energy Synthesis System

Researchers at the University of California, Davis have developed a novel system for acetoin and 2,3-butanediol synthesis from carbon dioxide.

Metal-free affinity media/agents for the selective capture of histidine-rich peptide sequences

The present invention utilizes metal-free synthetic polymer-based materials for the purification of peptides and proteins containing or being fused with histidine-rich sequences, which does not damage the function of the target protein and is less costly.

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