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Imaging of cellular immune response in human skin

This patent application describes methods for non-invasive, label-free imaging of the cellular immune response in human skin using a nonlinear optical imaging system.

High throughput and precision cell sorting

A novel method and device for high-throughput sorting of cells in suspension, particularly focusing on the separation of key cellular blood components of the immune system. The patent application presents a novel approach to high-throughput cell sorting, particularly suitable for applications in medicine and biotechnology where precise separation of cell populations is crucial.

Quantifying optical properties of skin

The disclosed methods offer a robust approach to accurately quantify skin optical properties across different skin tones, facilitating improved diagnosis, monitoring, and treatment in dermatology.

Purification of Glycosphingosines and Glycosphingolipids

Researchers at the University of California, Davis (UC Davis) have developed a simplified procedure to synthesize complex glycosphingosine compounds for the chemical preparation of glycosphingolipids.

System And Method For Tomographic Fluorescence Imaging For Material Monitoring

Volumetric additive manufacturing and vat-polymerization 3D printing methods rapidly solidify freeform objects via photopolymerization, but problematically raises the local temperature in addition to degree-of-conversion (DOC). The generated heat can critically affect the printing process as it can auto-accelerate the polymerization reaction, trigger convection flows, and cause optical aberrations. Therefore, temperature measurement alongside conversion state monitoring is crucial for devising mitigation strategies and implementing process control. Traditional infrared imaging suffers from multiple drawbacks such as limited transmission of measurement signal, material-dependent absorptions, and high background signals emitted by other objects. Consequently, a viable temperature and DOC monitoring method for volumetric 3D printing doesn’t exist.To address this opportunity, UC Berkeley researchers have developed a tomographic imaging technique that detects the spatiotemporal evolution of temperature and DOC during volumetric printing. The invention lays foundations for the development of volumetric measurement systems that uniquely resolve both temperature and DOC in volumetric printing.This novel Berkeley measurement system is envisaged as an integral tool for existing manufacturing technologies, such as computed axial lithography (CAL, Tech ID #28754), and as a new research tool for commercial biomanufacturing, general fluid dynamics, and more.

LaserPack: A burstable liquid storage package for biological material storage and valve substitution

The LaserPack is an easily manufacturable solution for liquid storage in point-of-care devices that is low-cost, has dimensional variability, and is reproducible, while also serving as a valve for liquid access in microfluidic devices. Current liquid storage techniques rely on lyophilization, or freeze-drying, to minimize occupied space, but lyophilization is not applicable to all liquid reagents nor is it optimal for some biological components of point-of-care devices.

A Discrete Color Approach for Stress Mitigation in Medical and Related Healthcare Applications as Applied to the Lighting Of Interiors and/or Medical Apparatus

The California Lighting Technology Center at UC Davis in collaboration with the Center for Mind and Brain have developed a novel lighting technology approach for stress recovery and stress mitigation.

(2023-117) Resilience and Wisdom Training (RWT)

Stress and loneliness are biologically toxic factors with adverse effects on mental and physical health. The 2018 Gallup World Poll found a 25%–40% increase in stress, worry, and anger in the US from 2008 to 2018. Loneliness is associated with considerable distress, and older adults are vulnerable to loneliness due to losses, physical decline, and social isolation. The COVID-19 pandemic led to increased social isolation, though some older adults with higher levels of resilience and wisdom faced the pandemic with greater fortitude than younger adults.Aging is associated with numerous stressors that negatively impact older adults’ well-being. Resilience improves ability to cope with stressors and can be enhanced in older adults. Senior housing communities are promising settings to deliver positive psychiatry interventions due to rising resident populations and potential impact of delivering interventions directly in the community. 

Use Of Terpenoids And Salicylates As Anesthetics, Analgesics, And Euthanasia Agents

Researchers at the University of California, Davis have developed agents made from terpenoids and salicylates that can be used as anesthetics in human and non-human animals, as well as environmentally friendly euthanasia agents in food-producing animals.

Polysaccharide A-Based Particulate Systems For Attenuation Of Autoimmunity, Allergy and Transplant Rejection

Researchers at the University of California, Davis have developed a customizable polysaccharide that can be added to nanoparticles to reduce their rejection by the human immune system.

Optimized Non-Addictive Biologics Targeting Sodium Channels Involved In Pain Signaling

Researchers at the University of California, Davis have developed high potency and selective peptide inhibitors that act as a non-addictive analgesic for relief of chronic and/or severe pain in humans.

Cannabigerol (CBG) In The Treatment Of Seizures And Epilepsy

Researchers at the University of California, Davis have developed a method of treating or mitigating seizure, treating epilepsy, as well as a method of reducing the frequency of seizures, using cannabigerol or dihydrocannabigerol and analogs thereof.

Psychoplastogens For Treating Hearing-Related Disorders

Researchers at the University of California, Davis, have developed a novel approach to treat hearing-related disorders with a new type of psychoplastogen that can increase the synapse density in the ear, correlating with hearing ability.

Safety Scalpel for Removal of Gastrostomy Tubes

A researcher at the University of California, Davis has developed a safety scalpel for mitigating the challenges associated with the removal of certain types of percutaneous implants, such as gastrostomy tubes having difficult to reduce anchoring elements.

Vascular Anastomosis Device

Researchers at the University of California, Davis have developed a surgical device to facilitate vascular anastomosis procedures with enhanced ease and speed.

Positive Allosteric Modulators Target TRPV1 with Analgesic Effects

Researchers at the University of California, Davis have developed de novo positive allosteric modulators (PAMs) that bind to TRPV1 proteins involved with pain-sensing in order to provide analgesic effects.

(SD2021-225) Wireless Contact Force Sensing and Localization

Contact force is a natural way for humans to interact with the physical world around us. However, most of our interactions with the digital world are largely based on a simple binary sense of touch (contact or no contact). Similarly, when interacting with robots to perform complex tasks, such as surgery, we need to acquire the rich force information and contact location, to aid in the task. To address these issues, researchers at UC San Diego have developed WiForce, which is a ‘wireless’ sensor that can be attached to an object or robot, like a sticker. WiForce’s sensor transduces force magnitude and location into phase changes of an incident RF signal, which is reflected back to enable measurement of force and contact location.

Method for Estimating Blood Plasma Water Content Using Portable NMR Relaxometry

Researchers at the University of California, Davis have developed a method of estimating blood plasma water content using nuclear magnetic resonance (NMR) relaxometry.

Medical/Surgical Instrument-Bending Device

Researchers at the University of California, Davis have developed a device that allows needles to be reliably and easily bent to a range of specified and reproducible angles. The device also enables protection of the needle tip and the maintenance of needle sterility during bending.

Neural Network Machine Learning Applied to Diagnose Acute Kidney Injury

Researchers at the University of California, Davis have developed machine learning models to enhance the accessibility and accuracy of acute kidney injury (AKI) testing.

Inter-Brain Measurements for Matching Applications

This technology utilizes inter-subject measurement of brain activity for the purpose of matching individuals. In particular, the invention measures the similarity and differences in neural activity patterns between interacting individuals (either in person or online) as a signature measurement for their matching capabilities. Relevant applications can be in the world of human resources (e.g., building collaborative teams), patient-therapist matching and others. The application relies on the utilization of both custom and commercial devices for measuring brain activity.

Programmable System that Mixes Large Numbers of Small Volume, High-Viscosity, Fluid Samples Simultaneously

Researchers at the University of California, Davis have developed a programmable machine that shakes and repeatedly inverts large numbers of small containers - such as vials and flasks – in order to mix high-viscosity fluids.

Growth-Accomodating Transcatheter Pulmonary Valve System

UCI researchers have developed a novel transcatheter pulmonary valve (TPV) that addresses the current lack of options for children with progressive pulmonary valve regurgitation (PVR), which may lead to right ventricular (RV) dysfunction and failure. This TPV allows for implantation into patients of a younger age, preventing the progression of PVR and the RV issues that follow, and can also expand to accommodate the need for a larger pulmonary valve as the patient grows.

Antibiotic to Fight Gram Negative and Resistant Bacteria

Researchers at the University of California, Davis have developed a gyramide antibiotic which is effective against Gram-negative and fluoroquinolones (FQs) resistant bacteria.

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