This technology represents a breakthrough in non-invasive hemodynamic monitoring by utilizing coherent light to assess physiological parameters with high accuracy

A researcher at the University of California, Davis has developed a system for supporting neonatal babies locally near the incubator for easy medical examination and procedures.

Researchers at the University of California, Davis have developed advanced compounds targeting neuraminidase activity to combat viral infections and understand cellular mechanisms.

Researchers at the University of California, Davis have developed a unique approach to target solid tumors using novel Fas-targeting antibodies designed for improved selectivity and efficacy in immunotherapy.

Researchers at the University of California, Davis, have developed new synthesis methods for the rapid and highly pure production of glycosphingolipids. The prototyped process can produce pure glycosphingolipids that can be used within basic disease research and drug and diagnostic development.

      While robots have proven effective in enhancing the precision and time efficiency of MRI-guided interventions across various medical applications, safety remains a formidable challenge for robots operating within MRI environments. As the robots assume full control of medical procedures, the reliability of their operation becomes paramount. Precise control over robot forces is particularly crucial to ensure safe interaction within the MRI environment. Furthermore, the confined space in the MRI bore complicates the safe operation of human-robot interaction, presenting challenges to maneuverability. However, there exists a notable scarcity of force-controlled robot actuators specifically tailored for MRI applications.       To overcome these challenges, UC Berkeley researchers have developed a novel MRI-compatible rotary series elastic actuator module utilizing velocity-sourced ultrasonic motors for force-controlled robots operating within MRI scanners. Unlike previous MRI-compatible SEA designs, the module incorporates a transmission force sensing series elastic actuator structure, while remaining compact in size. The actuator is cylindrical in shape with a length shorter than its diameter and integrates seamlessly with a disk-shaped motor. A precision torque controller enhances the robustness of the invention’s torque control even in the presence of varying external impedance; the torque control performance has been experimentally validated in both 3 Tesla MRI and non-MRI environments, achieving a settling time of 0.1 seconds and a steady-state error within 2% of its maximum output torque. It exhibits consistent performance across low and high external impedance scenarios, compared to conventional controllers for velocity-sourced SEAs that struggle with steady-state performance under low external impedance conditions.

Researchers at the University of California, Davis have developed a system that significantly improves the accuracy and efficiency of stress detection through electrodermal activity monitoring.

Researchers at the University of California, Davis, have developed a new optoretinography) imaging and analysis system for diagnosing and monitoring retinal health and diseases.

Researchers at the University of California, Davis have developed a novel 3D printing approach to culture and construct epithelial tubular mini-tissues.

An innovative technique to produce dissolvable calcium alginate microfibers using an immersed microfluidic spinning process for creating tissue constructs and vascularized tissue implants.

Researchers at the University of California, Davis have developed an approach to elicit powerful immune responses by engineering the binding capabilities of single chain trimer (SCT) proteins to CD8.

Researchers at the University of California, Davis have developed a semiautomated solution for identifying differences in tissue architectures or cell types as well as visualizing and analyzing cell densities and cell-cell associations in a tissue sample.

Researchers at the University of California, Davis have developed an operant behavioral assay to study thermosensation, pain, or avoidance and tolerance of an animal to noxious environments.

Researchers at the University of California, Davis (“UC Davis”) have developed a unisex swimwear garment designed to prevent swimming-related injuries and to assist in injury recovery during training.

Professor Kendrick Davis and colleagues from the University of California, Riverside have developed measurement and mapping survey technology that is easy to use, pictorial based, and written by a design that ensures present and ongoing scale validation with Unicode for standardization across virtually all electronic platforms. The emoji-based measurement system (Eb-MS) consists of a linked/connected set of tables organized by three master sets, and sets of linked tables as domain families (i.e., Medicine, Education, etc.) This technology is advantageous because it may facilitate effective communication with individuals with certain health situations, such as stroke, brain injury, or vocal impairments, or with language barriers. 

            Recent advancements in nuclear magnetic resonance (NMR) spectroscopy have underscored the need for novel instrumentation, but current commercial instrumentation only performs well for pre-existing, mainstream applications. Modalities involving, in particular, integrated electron-nuclear spin control, dynamic nuclear polarization (DNP), and non-traditional NMR pulse sequences cannot be commercialized without more flexible and capable hardware and software. The current shortcomings may impede innovative NMR methodologies from reaching the market in coming years.            To overcome this challenge, UC Berkeley researchers have developed a novel high-speed, high-memory NMR spectrometer and hyperpolarizer. The device is compact, rack-mountable and cost-effective compared to existing spectrometers. Furthermore, the spectrometer features robust, high-speed NMR transmit and receive functions, synthesizing and receiving signals at the Larmor frequency and up to 2.7GHz. The spectrometer features on-board, phase-sensitive detection and windowed acquisition that can be carried out over extended periods and across millions of pulses. These and additional features are tailored for integrated electron-nuclear spin control and DNP. The invented spectrometer/hyperpolarizer opens up new avenues for NMR pulse control and DNP, including closed-loop feedback control, electron decoupling, 3D spin tracking, and potential applications in quantum sensing.

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Rapid antimicrobial susceptibility testing (AST) is a method for quickly determining the most effective antibiotic therapy for patients with bacterial infections. These techniques enable the detection and quantification of antibiotic-resistant and susceptible bacteria metabolites at concentrations near or below ng/mL in complex media. Employing bacterial metabolites as a sensing platform, the system integrates machine learning data analysis processes to differentiate between antibiotic susceptibility and resistance in clinical infections within an hour. With the results, a clinician can prescribe appropriate medicine for the patient's bacterial infection.

Researchers at the University of California, Davis have developed a device for multi-dimensional data extraction at the molecular level to allow one to simultaneously detect the presence of a single-molecule electrically, and to extract a chemical fingerprint to identify that molecule optically.

Researchers at the University of California, Davis have developed a technology providing the creation of stable analogs of glycosphingosines and gangliosides containing O-acetylated sialic acid for extensive biological and medical applications.

The invention entails a unique catheter device utilizing electromotive drug administration (EMDA) to enhance drug penetrance into tissues of the ureter, renal pelvis, and calyces. By incorporating a conductive wire and fluid delivery system, the catheter enables targeted drug delivery, potentially revolutionizing the treatment of kidney stones, urothelial carcinoma, infections, and inflammation without systemic side effects.

The invention presents a microfluidic platform equipped with specialized trapping arrays and droplet generation capabilities, enabling precise control over the formation of microvortices within cell-laden droplets. This novel system facilitates the study of cell-cell interactions at a single-cell level, offering configurable microenvironments for analyzing cell dynamics and pair relationships.

A comprehensive method for automated multi-organ segmentation based on deep fully convolutional networks and adversarial training, achieving superior results compared to existing techniques.

An innovative direct drive hearing device, with a removable outside component that allows high quality sound and prolonged usage.

An innovative mass spectrometry platform that utilizes sulfoxide-containing MS-cleavable heterobifunctional photoactivated cross-linkers to enhance protein structural elucidation.