Improved Trap Geometry For Optimal Hydrodynamic Intra-Droplet Microvortices.

Brief Description

An advanced microfluidic platform that enables high-throughput 3D imaging of live, non-adherent single cells using droplet-based microvortex rotation.

Full Description

ADOPT is an innovative microfluidic device featuring an improved droplet trap design that immobilizes cell-laden droplets and uses oil flow-induced shear to generate microvortices, continuously rotating encapsulated cells for detailed 3D fluorescent imaging of cellular surfaces and intracellular structures. This scalable array of traps offers enhanced droplet stability, uniform fluid flow, and higher throughput, allowing highly parallelized imaging of live cells with improved bright field visualization.

Suggested uses

• Enables continuous rotation of encapsulated cells for comprehensive 3D imaging 
• High droplet trapping stability and uniform fluid flow 
• Scalable array design allowing parallelized, high-throughput cellular analysis 
• Improved bright field visualization of droplets and cellular contents 
• Applicable to both mammalian and plant cells offering versatile imaging

Advantages

• Agricultural biotechnology including plant breeding and crop protection 
• Drug discovery and vaccine development in mammalian cell research 
• Cancer research and personalized medicine 
• Environmental monitoring and homeland security 
• Forensic analysis and cellular diagnostics

Patent Status

Patent Pending