Next-Generation Engineered Adenine Base Editor (ABE)

Brief Description

A highly precise and efficient gene-editing tool designed to correct single-nucleotide DNA mutations responsible for genetic diseases.

Full Description

This advanced adenine base editor integrates engineered TadA8e and SpyCas9 modifications to enable precise correction of single-nucleotide changes in DNA. It offers improvements over existing base editors by enhancing efficiency, accuracy, and PAM-independence, while reducing off-target effects and enabling a smaller size for more effective in vivo delivery. This allows targeting of previously inaccessible genetic mutations with reduced risk of unintended DNA alterations.

Suggested uses

• Gene therapy for inherited genetic disorders 
• Biomedical research and functional genomics 
• Development of precision medicine treatments 
• Agricultural biotechnology for crop improvement 
• Pharmaceutical development targeting genetic conditions

Advantages

• Increased editing efficiency and accuracy 
• PAM-independent targeting expands editable genome range 
• Smaller molecular size enhances delivery in vivo 
• Reduced off-target and unintended DNA modifications 
• Capability to target difficult or previously unreachable mutations