Virus-encoded DNA-binding Proteins
Tech ID: 33547 / UC Case 2024-126-0
Patent Status
Patent Pending
Brief Description
Rapid virus evolution generates proteins essential to infectivity and replication but with unknown function due to extreme sequence divergence. Using a database of 67,715 newly predicted protein structures from 4,463 eukaryotic viral species, it was found that 62% of viral proteins are structurally distinct and lack homologs in the Alphafold database. Structural comparisons suggested putative functions for >25% of unannotated viral proteins.
UC Berkeley researcher have created new single stranded DNA (ssDNA) binding
proteins and double stranded (dsDNA) binding proteins, and methods and compositions for using them, such as binding to target DNA.
Suggested uses
- Gene editing
Contact
- Terri Sale
- terri.sale@berkeley.edu
- tel: View Phone Number.
Inventors
- Doudna, Jennifer A.
Other Information
Additional Technologies by these Inventors
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- THERMOSTABLE RNA-GUIDED ENDONUCLEASES AND METHODS OF USE THEREOF (GeoCas9)
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- Efficient Site-Specific Integration Of New Genetic Information Into Human Cells
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