The LaserPack is an easily manufacturable solution for liquid storage in point-of-care devices that is low-cost, has dimensional variability, and is reproducible, while also serving as a valve for liquid access in microfluidic devices. Current liquid storage techniques rely on lyophilization, or freeze-drying, to minimize occupied space, but lyophilization is not applicable to all liquid reagents nor is it optimal for some biological components of point-of-care devices.
● Aqueous solution storage within centrifugal disc-based point-of-care devices
● Key advantages in dimensional variability, cost, reproducibility, and compatibility with automation
● Would not require lyophilization
● Uses less material by combining storage and valving
Point-of-care testing (POCT) provides rapid, reliable results that aid in the identification and monitoring of acute infections or chronic disease. Rapid antigen tests for COVID-19 are a recent and relevant example of these tests. POCT devices must be compact for effective distribution and use, thus posing limitations on space. In an effort to save space, many POCT device developers have turned to lyophilization, or freeze-drying, of liquids required for the test. Unfortunately, this requires the addition of solvents prior to POCT use, and not all liquids can be lyophilized.
Researchers at UC Irvine have created a compact and flexible liquid storage device called LaserPack. It is impermeable to liquids and solids, and it is resistant to force-induced tearing, but the liquid can be accessed using a laser. Additionally, it doubles up as a valve for the POCT device that it would be implemented in, allowing for further space-saving utility. Furthermore, LaserPack is made using low-cost and widely available black mylar material.
|Patent Cooperation Treaty||Published Application||WO 2022/221772||10/20/2022||2021-767|
Additional Patent Pending
Patent published, prototype in development
Patent No.: US2022/0331802A1 (Oct. 20, 2022)