Cell interactions are fundamental to biological processes. Microfluidics provides a reliable platform to study these intricate phenomena. The researchers have developed a microfluidic trapping array which efficiently pairs single cells in isolated compartments in an easy to operate manner to study cell-cell interaction, especially at single-cell level.
Cell-cell interaction analysis to study fundamental biological processes including adaptive immune responses, stem cell differentiation, embryogenesis, and tumor progression.
·Microfluidics provides a reliable solution as a single-cell manipulation platform.
·Avoids the cross interference multiple paired cells in the shared microenvironment.
·Eliminates the use of animal models.
·Rapid and cost effective.
The researchers have developed a microfluidic trapping array which efficiently pairs single cells in isolated compartments in an easy to operate manner. The cell pairs are sealed with a particular reagent that allows for continuous supply of media for long term cell culturing and promotes pairing. Pairing including metabolic behavior of the cell pairs were observed by a proprietary imaging tool. This unique, microfluidics platform that pairs single cells is especially useful in studying cell-cell interactions.
Prototype with initial results.