Tech ID: 29072 / UC Case 2014-156-0

Invention Novelty

This invention is a novel technology developed to treat a patient’s neurological and/or psychiatric conditions. It consists of a system of implantable devices and computational algorithms that not only has autonomous control in sensing and stimulation of electrical signals in the patient’s brain, but also enables interactions with the external environment, thereby enhancing training and learning.

Value Proposition

Current methodologies such as deep brain stimulation and responsive neurostimulator systems are insensitive to variability in patient responses due to environment, physiology and/or behavior. This invention overcomes such limitations by enabling real-time monitoring and enhancement of brain states as the external environment changes during therapy. 

 This novel invention provides the following advantages:

  • Ameliorate symptoms of neuropsychiatric disorders such as Major Depressive Disorder, Addiction, Bipolar Disorder and Post-Traumatic Stress Disorder.
  • Automatic internal and external real-time modulation of electrical signals in the patient’s brain based on behavioral, physiological and environmental sensing.
  • External sensing enables the flexibility of incorporating dynamic real-life or more controlled conditions into the therapy of the patient, e.g. brain signal changes from medication or from environmental stimuli.


Technology Description

Researchers at the University of California, San Francisco have developed a novel technology to treat neuropsychiatric disorders. It involves implanting a set of devices into specific locations of the patient’s brain to sense, receive, record and generate electrical signals in a closed feedback loop. Internal electrical signals from the brain are automatically recorded by the devices and then processed to algorithmically select parameters to generate the appropriate electrical signals back to the brain. The invention has also incorporated software and wireless technology to additionally combine input from the external environment, which can provide a more interactive and dynamic therapeutic treatment, e.g. for patient-specific calibration and fine-tuning of the electrical stimulation in a more controlled environment.

Looking for Partners

To develop and commercialize this technology for the therapeutic treatment of neuropsychiatric disorders.

Stage of Development



Edward Chang

Data Availability

Under NDA/CDA.

Patent Status

Country Type Number Dated Case
European Patent Office Published Application 3606598 02/12/2020 2014-156
United States Of America Published Application 20200038657 02/06/2020 2014-156
Patent Cooperation Treaty Published Application WO2018187785 10/11/2018 2014-156


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Other Information


Deep Brain Stimulation, Responsive Neurostimulator System, Brain, Electrical Stimulation, Electrical Signals, Neuropsychiatric Disorders, Major Depressive Disorder, Generalized Anxiety Disorder, Post-Traumatic Stress Disorder, Addiction, Anorexia, Obsessive-Compulsive Disorder, Bipolar Disorder, Neural Plasticity

Categorized As