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Manumeter for Monitoring and Assessing Upper Extremity Rehabilitation

After an injury or neurological event, a patient’s rehabilitation requires long-term assessment and monitoring, especially in the upper extremities that are important for everyday tasks.UCI researchers have developed the Manumeter to quantitatively assess and log a patient’s hand movements without external therapist intervention.

Titanium Implants with Novel Roughness

UCLA researchers in the School of Dentistry at the Weintraub Center for Reconstructive Biology have developed a novel titanium implant with hierarchical multi-scale roughness to promote bone growth.

Effective Repetitive Transcranial Magnetic Stimulation (rTMS) Taking in Account Real-Time Frequency and Phase Of Intrinsic Brain Activity

Current research and practice in the field of therapeutic rTMS is not taking into account 1) inter-individual variability 2) variability between brain areas 3) variability or differences between oscillations in distinct and overlapping frequency bands, 4) existence of high- and low-excitability phase periods in each oscillatory cycle. Clinical treatments with rTMS and experimental research findings show mixed effects, with rTMS protocols inducing variable degrees of brain plasticity over subjects and sessions.

Apparatus and Methods for Stimulating DNA Repair Using Red Light Therapy

Red light exposure can have phototherapeutic effects on skin cells and other biological cells and tissues affected by UV damage. However, existing methods and devices using red light in DNA phototherapy have not identified the proper duration, intensity, or delivery mechanisms for optimal DNA repair. If the radiant intensity of the red light is too low, then exposure is inadequate and the repair biomarkers are not activated. Conversely, prolonged exposure to excessive electromagnetic radiation only furthers DNA damage. Moreover, in the context of skin treatment, excessive radiant intensity can burn tissue or have carcinogenic side effects. Thus, there is a need for a device and methods of use that provide safe, effective, and targeted red light DNA phototherapy.

Method and Apparatus for Movement Therapy Gaming System

Rehabilitation therapy, while an important tool for the long term recovery of patients affected by brain injury or disease, is expensive and requires one-on-one attention from a certified healthcare professional. UCI researchers have developed a computer-based system that provides arm movement therapy for patients. The system allows patients to independently practice hand and arm movements, improving therapeutic outcomes, while reducing hospital visits and cost for both patients and healthcare providers.

A New Approach To Treat/Manage Inflammatory Bowel Disease

Researchers at UCI have developed a safe, inexpensive drug for the treatment of inflammatory bowel diseases.

Novel Clotrimazole Analogs As Blockers Of Intermediate Conductance Kca Channels

Researchers at the University of California, Davis, have developed a method for preparing therapeutically effective amounts of triarylmethane compounds for immunosuppressive treatment of autoimmune disorders, graft rejection, and graft or host disease.

An On-Bed Monitoring System For Rehabilitative Exercises

UCLA researchers have developed a novel method for monitoring rehabilitative exercises using a bed sheet with high-density pressure sensors.

New Method for Generation of Human Pacemaker Cardiomyocytes

The heart consists of a multitude of diverse cardiomyocyte cell types, including atrial, ventricular and pacemaker cells, which cooperate to ensure proper cardiac function and circulation throughout the body. The rhythm of the heart beat is regulated by the sinoatrial node (SAN), functionally known as the cardiac pacemaker. Loss or dysfunction of these pacemaker cardiomyocytes leads to severe cardiac arrhythmias, syncope and/or even death. Although artificial pacemakers exist to help overcome these issues, several serious limitations and problems have emerged with this approach over the past several decades including electrode fracture or damage to insulation, infection, re-operations for battery exchange, and venous thrombosis. Moreover, size mismatch and the fact that pacemaker leads do not grow with children are a concerning problem. Thus, replacing artificial pacemakers with biological pacemakers potentially overcomes these artificial pacemaker issues including the expense and complications associated with device replacement, device or lead failure, and infection. To achieve these goals, understanding how pacemaker cardiomyocytes are generated is necessary to develop a human biological pacemaker for cardiac cellular therapies.

Immersive Virtual Reality To Manage Pain

Researchers led by Mark Cohen from the Department of Psychiatry at UCLA have developed a virtual reality-based therapy to manage chronic pain.

Targeting Kidney Stones: A Neutraceutical Formulation / Functional Food containing Bioactives

Changing diets and lifestyles are causing dramatic increases in painful kidney stones. Tastes for high-salt processed foods, high-sugar foods and drinks, and poor hydration are all causes. It is estimated that 10-20% of the population will develop a kidney stone, resulting in extreme pain, which may require surgical intervention. Alongside direct medical procedures, patients are often given potassium citrate pills as an adjunct therapy, but these are poorly-tolerated due to gastrointestinal side effects and large size of the pills, all of which decrease patient compliance. These current formulations require a twice-a-day dosing regimen, which only exacerbates the compliance problem. However, beyond these citrate pills, sadly few effective medical alternatives exist. To remedy this problem, UC San Diego physicians have recently developed a neutraceutical formulation, specifically designed to comprise precise balance of bioactives within a well-tolerated functional food, supporting the targeted relief of kidney stones.

Pain Assessment Method And Apparatus For Patients Unable To Self Report Pain

Though pain assessment is a crucial part of many medical treatment plans, most physicians rely on patients self-reporting their own pain levels. This self-reporting strategy may be convenient to some patients trying to determine whether the patient should get to a doctor, but in some situations, especially where a patient is non-communicative or incapacitated, these patients may be unable to clearly express themselves to a medical professional. As such, researchers at UCI have developed a novel device that automatically and objectively monitors a patient’s pain levels by tracking/monitoring subconscious facial movements in real-time.

Bioinspired Hydrogels for the Treatment of Volumetric Muscle Loss Injury

Injuries that involve a degree of muscle tissue loss that exceeds the endogenous regenerative capacity of muscle, resulting in permanent cosmetic and functional deficits of either the injured muscle or the muscle unit, are referred to as volumetric muscle loss (VML) injuries. Current treatment for VML injury involves surgical muscle transfer, although these procedures are often associated with poor engraftment and donor site morbidity.    UC Berkeley and U.Va researchers have developed a new technology for the treatment of VML injuries that overcomes the limitations associated with current treatments for VML injury.  The Matrix Assisted Cell Transplantation (MACT) technology developed by the researchers employs “bioinspired” materials designed to emulate regulatory processes that modulate cell function in the stem/progenitor cell microenvironment.  The technology includes: 1) peptide ligands to imitate the natural extracellular matrix (ECM); 2) proteolytic remodeling via matrix metalloproteinase (MMP) sensitive peptide crosslinks; and, 3) growth factors with engineered density and presentation.    The technology and the materials used have been shown to significantly improve donor survival after transplantation, promote angiogenesis, and encourage donor cell integration with the host tissue.

Wearable Real-Time Gait Analysis And Sensory Feedback System For Gait Rehabilitation And Biomechanical Optimization

UCLA researchers in the Department of Bioengineering have developed a wearable sensory feedback system that provides instructive tactile feedback to guide the user towards biomechanical gait improvements, based on real-time motion analysis derived from wearable sensor data.

Dextrous Hand Exoskeleton

Researchers led by Professor Jacob Rosen from the Department of Mechanical and Aerospace Engineering at UCLA have developed a novel hand exoskeleton that provides sensory information to the user.

In vivo optical biopsy applicator of the vaginal wall for treatment planning, monitoring, and imaging guided therapy

Pelvic floor disorders (PFDs) afflict nearly 25% of all women and carry a host of symptoms that can drastically reduce quality of life. Despite their prevalence, the complex and varied nature of such PFDs make them difficult to diagnose and treat. Researchers at UCI have developed an entirely integrated system that, for the first time, provides real-time monitoring of the vaginal wall tissue during diagnosis and treatment, allowing for more thorough diagnoses and more effective treatment methods.

Virtual Reality Training Tasks Used For Stroke Rehabilitation

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a set of virtual reality training tasks that can be used for rehabilitation for post-stroke patients.

An Implantable Electrocorticogram (ECoG)-Brain-Computer Interface System for Restoring Lower Extremity Movement and Sensation

A fully implantable brain-computer interface (BCI) with onboard processing to control a robotic gait exoskeleton as a walking aid for individuals with chronic spinal cord injury (SCI). This technology would alleviate SCI patient’s dependence on wheel chairs, reducing the risk of secondary medical complications that account for an estimated $50 billion/year in healthcare costs.

Obstruction Prevention Airway Collar

Though deep sedation is a routine part of many medical procedures, patients under anesthesia are susceptible to airway obstruction as their throat and tongue muscles relax. Most common methods to prevent obstruction are complicated and carry additional risks. Researchers at UCI have developed a safe and comfortable medical collar that maintains patients’ airways and is entirely adjustable.

Full Body Haptic Device

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a full body haptic device that optimizes the location of the four robotic arms and allow the user to feel the force feedback from the interaction with VR objects.

Cloud based platform for display and analysis of image time series

Current microscopy systems commonly used in biomedical research labs and companies generate large amounts of large data, known as image stacks. There is currently no easy, streamlined way to store, organize and analyze these datasets on a cloud. Researchers at UCI have developed a software consisting of a cloud-based data management and analysis platform that make visualization and analysis of large image stacks simpler and faster.

NOVEL BRAIN TECHNOLOGY FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS USING ELECTRICAL STIMULATIONS

This invention is a novel technology developed to treat a patient’s neurological and/or psychiatric conditions. It consists of a system of implantable devices and computational algorithms that not only has autonomous control in sensing and stimulation of electrical signals in the patient’s brain, but also enables interactions with the external environment, thereby enhancing training and learning.

Half-Virtual-Half-Physical Microactuator

Researchers at the University of California, Davis have developed a half-virtual-half-physical microactuator that utilizes a combination of computational models and microelectromechanical systems for use in medical devices and mechanical systems.

Torque Balancing Active Wrist Brace

The invention is an orthopedic brace to aid in the rehabilitation of hand movements in stroke survivors. This spring-actuated brace provides the necessary hand-forearm support and counterbalances wrist stiffness/resistance to stretch typical to stroke patients. This device significantly reduces the effort required for a hand movement in patients with varying degrees of motion impairment.

Exercise Promotion, Measurement, and Monitoring System

UCLA researchers in the Department of Electrical Engineering have developed a novel wireless sensor and exercise system for real-time exercise promotion and monitoring.

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