A self-regenerative hybrid tissue structure for 3D fabrication of heart valves, blood vessels and other constructs

Tech ID: 23154 / UC Case 2011-607-0

Brief Description

Researchers at UC Irvine have developed a biocompatible and mechanically stable scaffold for engineering tissues that are capable of self-renewal. The hybrid tissue may be used as replacement heart valve leaflets and may also be used for tissue constructs like blood vessels.

Full Description

Existing scaffolds for building tissue constructs face drawbacks such as the leaching of toxic byproducts, provoking immunogenic reactions, and mechanical instability. Therefore, a continual need persists for a biocompatible and mechanically durable tissue construct.

Researchers at UC Irvine have developed a biocompatible, multi-layered scaffold construct that not only can withstand the physiological stresses within the body, but also continue to remodel and mature. The scaffold construct is composed of a wired mesh core that is entirely enwrapped in a three-dimensional manner with cells or materials of the user’s choice. The mesh core imparts biomechanical durability into the tissue construct, and allows for full integration of the formed tissue with the body.

Suggested uses

The tissue scaffold can be used to create engineered tissues such as heart valve leaflets or other vessel-like.


The scaffold construct is built to be biomechanically resilient in order to withstand the physiological stresses inside the body. Furthermore the mesh core allows the cells and extracellular matrix components to fully interact with each other, resulting in a biocompatible tissue construct.

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 10,610,616 04/07/2020 2011-607
United States Of America Issued Patent 9,925,296 03/27/2018 2011-607
United States Of America Issued Patent 8,936,650 01/20/2015 2011-607
United States Of America Issued Patent 8,900,862 12/02/2014 2011-607
United States Of America Published Application 20150081012 03/19/2015 2011-607

State Of Development

Novel hybrid tissue fabricated as heart valve leaflets have been made by UCI researchers.


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Other Information

Categorized As

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