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Novel Radiotracers for Imaging Glucocorticoid Receptor in Treatment-resistant Cancer Patients

UCSF researchers have invented novel radiotracers that allow imaging of glucocorticoid receptor (GR) expression using positron emission tomography (PET) in patients with treatment-resistant solid cancer, including prostate, breast, ovarian and lung cancer.

Transabdominal Fetal Blood Oximetry

Researchers at the University of California, Davis have developed a method and apparatus for clinical-grade transabdominal fetal blood oximetry.

Genetically Encoded Fluorescent Sensors for Probing the Action of G-Protein Coupled Receptors (GPCRs)

Researchers at the University of California, Davis have developed a genetically encoded fluorescent sensor toolbox for the probing of G-protein coupled receptors.

Stationary X-Ray Source

Researchers at the University of California, Davis have developed an integrated method of providing a long lived, high output stationary X-ray source.

Phasor camera for efficient spectral imaging

Researchers at the University of California, Davis have developed an imaging system for quickly capturing and analyzing spectral images.

A Method Of Computational Image Analysis For Predicting Tissue Infarction After Acute Ischemic Stroke

UCLA researchers in the Departments of Radiological Sciences and Neurology have designed an algorithm to predict tissue infarctions using pre-therapy magnetic resonance (MR) perfusion-weighted images (pre-PWIs) acquired from patients with acute ischemic stroke. The predictions generated by the algorithm provide information that may assist in physicians’ treatment decisions.

Rapid And Selective Cycloaddition Reaction For Applications In Molecular Imaging

UCLA researchers in the Department of Molecular and Medical Pharmacology, and Department of Chemistry and Biochemistry have designed a new reaction with 18F-chemistry platform, allowing a highly selective, efficient and rapid approach to label biomolecules with a chemical reporter (i.e. radionuclide, fluorescent dye) for molecular imaging.

Apparatus And Method For Multiple-Pulse Impulsive Stimulated Raman Spectroscopy

UCLA researchers in the Department of Electrical Engineering have developed an apparatus and method for multiple-pulse impulsive stimulated Raman spectroscopy for molecule structure-level characterization.

PVA nanocarrier system for controlled drug delivery

Researchers at the University of California, Davis have designed and synthesized a unique type of water-soluble, biodegradable targeting poly(vinyl alcohol) (PVA) nanocarrier system for controlled delivery of boronic acid containing drugs, chemotherapy agents, proteins, photodynamic therapy agents and imaging agents.

An Optical Coherence Elastography (OCE) Method Under Acoustic Radiation Force Excitation Using OCT Doppler Variance Methods And OCT Correlation-Based Methods

Researchers at UCI have recently developed a non-invasive tissue diagnostic procedure that is simpler and more easily implemented than standard methods.

Novel Contrast Enhancement for Detection of Amyloid Beta Peptides using MRI, EPR, PET, and ESRM

Researchers at the University of California, Davis have developed nitroxide-coupled amyloid agents to produce contrast enhancement for amyloid beta peptide (Abeta) detection using MRI, EPR, PET, and ESRM.

Multiple in vivo tissue chromophores

The field of the invention generally relates to methods and devices used in diffuse optical spectroscopy. More specifically, the field of the invention generally relates to broadband diffuse optical spectroscopy methods and devices which are able to dynamically monitor multiple in vivo tissue chromophores. A device and method utilizes a broadband diffuse optical spectroscopy (DOS) system to dynamically calculate the concentrations of multiple chromophores in vivo using a non-invasive probe. The device and method permit dynamic monitoring of multiple in vivo tissue chromophores non-invasively with sensitivities necessary for effective therapeutic monitoring. The device includes a probe containing first and second source optical fibers as well as first and second detector optical fibers. The probe is placed adjacent to a sample of interest and detects reflected light which is passed to a proximally located detector and spectrometer. The concentrations of multiple chromophores are determined in real time. In a preferred embodiment, the multiple tissue chromophores include at least two of methemoglobin (MetHb), deoxyhemoglobin (Hb-R), oxyhemoglobin (Hb-O2), water (H2O), and methylene blue (MB). The device and method can be used quantify and monitor methemoglobin formation in subjects suffering from methemoglobinemia.

New label-free method for direct RNase activity detection in biological samples

Researchers at the University of California, Davis have developed a new and simple, label-free method to detect milligram levels of RNase activity in undiluted biological samples that is selective, accurate and scalable


Sucralose has become widely used as an artificial sweetener due in large part that it has low caloric content and is 600 times sweeter than table sugar (sucrose). Due to its resistance to metabolic degradation, sucralose can also be used as a marker for noninvasively assessing gastrointestinal small intestine or colonic permeability. This urinary marker is traditionally analyzed by time consuming and expensive methods, such as high performance liquid chromatography coupled to mass spectrometry or evaporative light scatter as the detectors. We have developed an alternative methodology of using a chemical-fluorescent technique for rapid analysis of halogenated disaccharides, such as sucralose.

Mechano-Nps (Node Pore Sensing)

The mechanical properties of cells derive from the structure and dynamics of their intracellular components, including the cytoskeleton, cell membrane, nucleus, and other organelles.  These, in turn, emerge from cell specific genetic, epigenetic, and biochemical programs, providing a link between cellular mechanics and the underlying molecular state.  Differences in mechanical properties reflect on cellular properties with clinical implications, including the metastatic potential, cell-cycle stage, and differentiation state of cells.  Yet, many mechanical aspects of various cells and sub-cell organelles remain unknown due to absence of appropriate analysis platforms. Atomic-force microscopy (AFM) and micropipette aspiration are the gold standards for performing mechanical measurements of cells, as they both provide controlled loading conditions and quantify such cellular properties as elastic modulus and cortical tension.  They are, however, burdened by slow throughput, capable of analyzing only just a few cells/hr.  Likewise, optical tweezers and microplate rheometry also suffer from low throughput.  Various microfluidic based platforms have been proposed for the high-throughput mechanical analysis of cells, including hydrodynamic stretching cytometry, suspended microchannel resonators (SMR), and real-time deformability cytometry (RT-DC).  Although each of these methods can analyze populations of cells in a relatively short time, they focus only on a single cellular property.  Consequently, these platforms, and the low-throughput traditional methods that under-sample, can neither identify cellular heterogeneity nor classify mechanical sub-phenotypes within a population. Investigators at UC Berkeley have developed a microfluidic platform, “mechano-node-pore sensing” (mechano-NPS), a rapid and multi-parametric cell screening platform, that simultaneously quantifies cell diameter, transit time through a contraction channel, transverse deformation under constant strain, and recovery time after deformation.  This platform efficiently reveals malignant-dependent mechanical phenotypes of cancer and normal epithelial cells, discriminates between sub-lineages of cells with accuracy comparable to flow cytometry, and determines the effects of chronological age and malignant progression on cell elasticity and recovery from deformation – based solely on a cell’s mechanical properties.

Voltage-Sensitive Dyes In Living Cells

96 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:Calibri; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Comprehensively mapping and recording the electrical inputs and outputs of multiple neurons simultaneously with cellular spatial resolution and millisecond time resolution remains an outstanding challenge in the field of neurobiology. Traditionally, electrophysiology is used to directly measure membrane potential changes. While this technique yields sensitive results, it is invasive and only permits single-cell recording.  VoltageFluor dyes rely on photoinduced electron transfer to effectively report membrane potential changes in cells. This approach allows for fast, sensitive and non-invasive recording of neuronal activity in cultured mammalian neurons and in ex-vivo tissue slices. However, one major limitation of small-molecule dye imaging is the inability to target the dye to specific cells of interest.   UC Berkeley researchers have developed latent voltage sensitive dyes that require a fluorogenic activation step. This new class of VoltageFluor dyes are only weakly fluorescent until being activated in defined cell types via biological processes. In particular, the VoltageFluor dyes described herein comprise a bioreversible group that quenches the fluorescence of the VoltageFluor dye, that upon selective removal by the action of biological processes (e.g., enzymes) thereby activates the fluorescence of the VoltageFluor dye. The researchers found that the new dye facilitated the observation of spontaneous activity in rat hippocampal neurons.  

Synthesis Technique to Achieve High-Anisotropy FeNi

Researchers at the University of California, Davis have developed an innovative synthesis approach to achieve high anisotropy L1 FeNi by combining physical vapor deposition and a high speed rapid thermal annealing (RTA).

Employing CRISPR-Cas9 to Target RNA in Live Cells

RNA's location in a cell -- and how and when it gets there -- can influence whether proteins are produced in the right location and at the appropriate time. For instance, proteins important to neuronal connections in the brain, known as synapses, are produced from RNAs located at these contacts. Defective RNA transport is linked to a host of conditions ranging from autism to cancer and researchers need ways to measure RNA movement in order to develop treatments for these conditions. As the intermediary genetic material that carries the genetic code from the cell's nucleus, scientists have long sought an efficient method for targeting RNA in living cells. RNA-programmed genome editing using CRISPR/Cas9 from Streptococcus pyogenes has enabled rapid and accessible alteration of specific genomic loci in many organisms. A flexible means to target RNA would allow alteration and imaging of endogenous RNA transcripts analogous to CRISPR/Cas-based genomic tools, but most RNA targeting methods rely on incorporation of exogenous tags.

Simple And Low-Cost Pseudo-Halbach Magnets For NMR

Nuclear magnetic resonance (NMR) spectroscopy exploits the magnetic properties of certain atomic nuclei to determine the physical and chemical properties of the substances in which they are contained. It can provide detailed information about the structure, dynamics, reaction state, and chemical environment of molecules, where the magnetic field is used to polarize atomic nuclei prior to detection of their signals. In conventional NMR magnet design, the homogeneity of the field is a principal consideration and should be made as uniform as possible to obtain the most informative results and best data quality. Researchers from UC Berkeley have developed an assembly of magnetized prisms with an orientation pattern to generate the strongest available magnetic field.  The design is based on the priority of achieving the strongest available field over a given volume irrespective of the homogeneity.  The team has designed and made a compact 2 T magnet to fulfil these objectives.

Method For Imaging Neurotransmitters In Vitro and In Vivo Using Functionalized Carbon Nanotubes

Neurotransmitters play a central role in complex neural networks by serving as chemical units of neuronal communication.  Quantitative optical methods for the detection of changes in neurotransmitter levels has the potential to profoundly increase our understanding of how the brain works. Therapeutic drugs that target neurotransmitter release are used ubiquitously to treat a vast array of brain and behavioral disorders.  For example, new methods in this sphere could provide a new platform by which to validate the function of drugs that alter modulatory neurotransmission, or to screen antipsychotic and antidepressant drugs.  However, currently in neuroscience, few optical methods exist that can detect neurotransmitters with high spatial and temporal resolution in vitro or in vivo.  Brain tissue also readily scatters visible wavelengths of light currently used to perform biological imaging, and neuronal tissue and has an abundance of biomolecules that are chemically or structurally similar and therefore hard to specifically distinguish.  Furthermore, neurotransmission relevant processes occur at challenging spatial  and temporal scales.    UC Berkeley investigators have developed polymer-functionalized carbon nanotubes for in vitro and in vivo quantification of extracellular modulatory neurotransmitter levels using optical detectors. The method uses the fluorescent optical properties of polymer-functionalized carbon nanotubes to selectively report changes in concentration of specific neurotransmitters. The scheme is novel in that the detection method applies to wide variety of specific neurotransmitters, it is an optical method and therefore gives greater spatial information, and enables the potential for imaging of one or more neurotransmitters. The optical method also produces less damage to the surrounding tissue than methods that implant electrodes or cells and allows high resolution localization with other methods of optical investigation. The invention takes advantage of favorable fluorescence properties of carbon nanotubes, such as carbon nanotube emission in the near infrared and infinite fluorescence lifetime.  The near infrared emission scatters less than shorter wavelengths, enabling greater signal recovery from deeper tissue, and allows greater compatibility with other techniques. The optical properties also enable long term potentially even chronic use. 

Highly Stable Nanoscale Disk Assemblies Of The Tobacco Mosaic Virus For Applications In Drug Delivery And Disease Imaging

96 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:Calibri; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Self-assembling protein nanomaterials derived from viruses have properties that make them useful for applications in drug delivery, disease imaging and diagnostics. These properties include uniform sizes and shapes, biodegradability, and multiple sets of functional handles for chemical manipulation. Intact virus nanoparticles have been functionalized for applications in drug delivery in vivo, however, the injection of replication-competent viruses into subjects have limited their clinical appeal. The development of spherical and rod-shaped virus nanoparticles has in both cases resulted in differential tumor accumulation, demonstrating the need to further expand the shape library of protein nanomaterials. However, expressing non-spherical virus-based protein nanomaterials without the genetic material that functions as a backbone to the assembly architecture can lead to significant challenges including poly-diversity in size and shape, and change in assembly behavior in response to different conditions such as pH and ionic strength.   UC Berkeley researchers have developed a self-assembling nanoscale disk derived from a mutant of a recombinantly expressed viral coat protein. The disks display highly stable double-disk assembly states. The researchers functionalized the disks with the chemotherapy drug doxorubicin (DOX) and further modified the disks for improved solubility.  The functionalized disks displayed cytotoxic properties similar to those of DOX alone when incubated with U87MG glioblastoma cells, but the unmodified disks did not cause any cytotoxicity.

Second Method For Nucleophilic Fluorination Of Aromatic Compounds With No-Carrier-Added [F-18] Fluoride Ion

UCLA researchers in the Department of Pharmacology have developed a novel aromatic nucleophilic fluorination reaction producing Fluorine-18 [F-18]-labeled aromatic compounds with extensive use in Positron Emission Tomography (PET).

Broadband Surface-Enhanced Coherent Anti-Stokes Raman Spectroscopy (SECARS) With High Spectral Resolution

UCLA researchers have developed a novel method to improve Raman spectroscopy sensitivity, spatio-temporal resolution, and broadband spectral range while reducing peak power and photo-damage.


The invention is a method for instantaneous and efficient extraction of radioactive isotopes with high specific activity, during continuous production at research reactors. The proposed method allows advantageous production of radioisotopes for various applications, including nuclear medicine uses (diagnostics, imaging, cancer treatments). In addition, the invention has the potential for applications related to isotopes used in thermoelectric generators (i.e. 238Pu) that power both medical devices, such as cardiac pacemakers, and deep space missions.

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