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Novel Software of Generating Attenuation Correction Maps with MRI for PET Reconstruction

This invention can accurately and rapidly map patient bone structure and classify all tissue types such as fatty soft tissue, water soft tissue, lung tissue, bone, and air within a single scan using novel MRI acquisition and reconstruction techniques.

Patient-Specific Ct Scan-Based Finite Element Modeling (FEM) Of Bone

This invention is a software for calculating the maximum force a bone can support. The offered method provides an accurate assessment of how changes in a bone due to special circumstances, such as osteoporosis or a long duration space flight, might increase patient’s risk of fracture.

A Method For Determining Characteristic Planes And Axes Of Bones And Other Body Parts, And Application To Registration Of Data Sets

The invention is a method for deriving an anatomical coordinate system for a body part (especially bone) to aid in its characterization. The method relies on 3-D digital images of an anatomical object, such as CT- or MR-scans, to objectively, precisely, and reliably identify its geometry in a computationally efficient manner. The invention is a great improvement over the current practice of subjective, user-dependent manual data entry and visualization of bones and organs. The applications for well-defined anatomical coordinate systems include robotic surgeries, models for bone density studies, and construction of statistical anatomical data sets.

Automated Liquid Volume Handler for Rapid Concentration of Radioisotopes

UCLA researchers in the Department of Pharmacology have developed a novel, rapid, and fully automated method of concentrating radioisotopes to allow production of PET imaging probes on a clinical scale.

Versatile, Modular and Affordable Microwave and Radiofrequency Magnetic Resonance Setup for Dynamic Nuclear Polarization

A DNP setup operating at a magnetic field at or above 5 Tesla, powered by a solid state microwave source, transmitted using low loss quasi optics and utilizes an externally tunable, inductively coupled radio frequency probe integrated into part of the waveguide to provide efficient microwave transmission to the sample while maintaining good NMR performance and complete hardware modularity.

A Novel Reversible Fluorescent Protein Complementation Assay for Imaging of Protein-protein Interactions

This invention provides a method for characterizing protein-protein interactions using a novel reversible bimolecular fluorescence complementation assay.

Bio-Imaging Of Aldehyde Dehydrogenase Activity

Aldehyde Dehydrogenase (ALDH) activity is essential for generating cancer stem cells and drug resistance in cancer stem cells, which are the primary cause of treatment failure in oncology. Similarly, ALDH activity also plays a therapeutic role in a variety of inflammatory diseases and is needed for tissue regeneration and wound healing after a myocardial infarct, the detoxification of xenobiotics in the liver, the alleviation of pain, and the prevention of Parkinson’s disease. There is therefore great interest in developing small molecules that can inhibit or activate ALDH activity, however, this is currently challenging because of the inability to measure ALDH activity in cells.  The current method measures ALDH in cells indirectly, via ALDH substrates that are unable to distinguish between non-specific accumulation and genuine ALDH activity, and can only indirectly measure ALDH activity via flow cytometry.  UC Berkeley researchers have developed bio-imaging agents to image ALDH activity in cells. The new agents can spectrally distinguish between the small electronegativity differences between an aldehyde and a carboxylate and are exceptionally sensitive to changes in electronegativity.   

UCLA Inventors Create Platform Technology to Create Customizable Materials for Imaging and Detection

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale vesicles and hydrogels for use in imaging and detection.The poly-peptide based platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, be loaded with hydrophobic and hydrophilic payloads, adaptable to specific delivery locations, low toxicity, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis.The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can also be used to augment existing nanoparticles.

Measurement Of Blood Flow Dynamics With X-Ray Computed Tomography: Dynamic Ct Angiography

This invention identifies a method to accurately measure flow dynamics, such as velocity and volume, from Computed Tomography scans of blood vessels in a patient.

Beta-Amyloid Plaque Imaging Agents

Current imaging agents for labelling β-amyloid plaques and neurofibrillary tangles (NFT), which are indicators for Alzheimer’s disease, suffer from drawbacks such as (but not limited to) non-specific binding, low target to non-target ratio, instability, and inefficient labelling. Researchers at UC Irvine have developed an imaging agent and its derivatives for labelling β-amyloid plaques and NFTs that overcome these problems and also provide therapeutic properties in vivo for the neural tissues. The labelling agent also binds to norepinephrine transporters (NET) and are taken up into the cells via the NET, therefore serving as suitable agents for diagnostic and/or therapeutic purposes involving disorders or conditions associated with NET.

Design and Synthesis of Fluoroalkylpyridyl Ethers as Potential Pet Radioligands for A4B2 Nicotinic Acetylcholine / Labeled A4B2 Ligands and Methods Therefor

Researchers have developed compounds to bind to α4β2 nicotinic acetylcholine receptors to evoke antagonistic effects both in vitro and in vivo environments.

Dynamic Contrast Optical Coherence Tomography (DyC-OCT): An improved method to quantify blood flow dynamics in deep tissue and microvasculature

Dynamic Contrast Optical Coherence Tomography (DyC-OCT) is a non-invasive technique that obtains high resolution images of blood flow dynamics in deep tissue. It involves real time imaging of the passage of a contrast agent through the vascular and capillary networks. Data analysis can then reveal detailed information on the temporal and spatial dynamics of blood flow.

Methods of Monitoring and Manipulating the Fate of Transplanted Cells

Tumor initiation and progression into metastasis are accompanied by complex structural changes in the extracellular matrix and cellular architecture that alters the stiffness in the microenvironment of the cell.

An integrated intraoperative diagnosis and therapy catheter system

In traditional cardiology and oncology, disease diagnosis and treatment are traditionally separate procedures resulting in increased costs and delayed treatment, which, in some cases, may increase morbidity. Therefore, a system that can diagnose and treat diseases simultaneously would greatly decrease costs and provide timely treatment, which may prevent death from the disease. Researchers in the Department of Engineering at UC Irvine, in collaboration with researchers at Shanghai Jio Tong University in China have invented a multimodal system for the diagnosis and treatment of cancer and cardiac disease. Summary of development The present invention describes an intraoperative imaging and therapy catheter system for the accurate diagnosis and treatment of cancer and cardiac disease. This multimodal medical device combines imaging, cryosurgery, and thermal therapy thereby permitting accurate diagnosis and treatment of vulnerable plaques in blood vessels and various types of cancers. In addition, by adding low cost imaging modalities such as optical coherence tomography (OCT), ultrasound imaging, photoacoustic (PA) imaging, fluorescence imaging and thermal imaging, cryosurgery can be performed with much higher accuracy. Importantly, addition of these imaging systems enables accurate identification of lesion sites, precise depth of cryosurgery/heating probe placement, and the capability to monitor the extent of the freezing/heating process. Furthermore, the invention may include intravascular ultrasound (IVUS) facilitating visualization of cross-sectional images of the vessel wall, entire large lipid pools, and large tumor regions. These parameters are valuable for the guidance of cryoplasty regarding the treatment time, temperature and location.

Compressive Plenoptic Imaging

Better understanding the brain's architecture and the behavior of neural networks requires non-invasive probes capable of monitoring brain activity at the scale of individual neurons.  Functional neuro-imaging methods have the advantage of being minimally invasive and can potentially resolve individual action potentials.  An ideal imaging method would be capable of quantifying many neurons simultaneously, have high spatial and temporal resolution, be non-invasive, and be accurate even in deep layers of brain tissue. There are a variety of current techniques available, many of which use mechanical scanning to reduce the effects of optical scattering and therefore have low temporal resolution. UC Berkeley researchers have developed a device capable of quantitative functional neuro-imaging in the thick brain tissue of live animals. By combining a detection method with algorithmic data processing, this device achieves single neuron resolution and fast sampling rates with high spatial and temporal resolution.  

Long Wavelength Voltage Sensitive Dyes

Rapid changes in the membrane potential of neurons and cardiomyocytes are used to define cellular signaling and cell physiological profiles. The classical means to monitor membrane potentials is patch clamp electrophysiology, a low-throughput and highly invasive technique. One current alternative is to use Ca2+ imaging, as the agents are robust and sensitive, come in a variety of colors, and can be used in a wide range of biological contexts. Ca2+ imaging, however, allows only an imperfect approximation of membrane potential changes, and fast-spiking neuronal events are difficult to detect.   Fluorescent voltage sensors can achieve fast, sensitive, and non-disruptive direct readouts of membrane potentials. UC Berkeley researchers have designed and synthesized a new fluorophore called ‘Berkeley Red’ that can be used in the context of voltage-sensing scaffolds to generate fluorescent voltage sensors.  

Methods And Utilizations For Tissue Staining And Digital Microscopy

The current state of the art in digital pathology is whole-slide imaging, in which tissues are fixed in formalin, processed and paraffin-embedded, cut, stained with standard reagents for tissue histochemistry, and placed on glass slides.  The glass slides are then scanned to create a digital image of the tissue.  Although this represents the current state-of-the-art, it is a very expensive, and time, and space-consuming process. 

Double Tuned Phase Array Coils for Simultaneous Proton and Heteronuclear MRI

UCSF researchers have developed a new double-tuned radiofrequency (RF) coil for simultaneous proton and heteronuclear magnetic resonance imaging (MRI). This novel coil design allows for independent frequency adjustments of the two magnetic resonance modes.

Raman Macro Imaging System for Fast Biocompatible Tissue Characterization

UCLA researchers in the Department of Electrical Engineering have developed a novel optical imaging system to detect early stages of abnormal bone formation in flesh.

A Simple, Area-Efficient Ripple-Rejection Technique for Chopped Bio-Signal Amplifiers

The Markovic group at UCLA has designed a chopping amplification technique with passive ripple-rejection that improves on the state-of-the-art in monitoring electrophysiological signals.

Automated Comparison of 3D Images

UCLA researchers in the Department of Radiology have developed an accurate and automatic segmentation algorithm for contouring cerebral blood vessels.

Real-Time Acoustic Measurement and Feedback for Surgical Implants

UCLA researchers have recently developed a method of measuring the proper fit and placement of medical implants based on the acoustic reverberations from hammering the implant into place.

Image Filtering Algorithm for Enhanced Noise Removal and Feature Preservation

UCLA researchers in the Department of Chemistry & Biochemistry have developed a novel image filtering algorithm that removes image noise while preserving image features with unprecedented fidelity.   

Advanced Tagging Method for Real-Time MRI of Heart Function

UCLA researchers in the Department of Radiology have developed an advanced MRI technique that significantly reduces image acquisition times during dynamic cardiac imaging, thereby enabling real-time strain imaging of heart tissue during exercise-induced stress. 

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