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EpiSort: A Novel Method Using Deep Bisulfite Sequencing to Determine Immune Cell Types in Solid Tissue Samples

EpiSort is a novel method of using DNA methylation patterns to determine the proportion of immune cell populations in solid tissue samples.

Structurally Validated Anti-avß8 Antibodies for Targeting TGFß for Immunotherapy

This invention provides highly efficient antibodies whose epitopes and mechanism of action have been structurally defined against integrin αvβ8. These antibodies have been designed to be used as therapeutic for cancer. Other antibodies have been designed as companion diagnostic tools.

METHOD FOR DETECTING AND TREATING NASAL AND LUNG DYSBIOSIS PATIENTS WITH MICROORGANISMS

This invention uses sequencing of microbiota community for diagnosis and treatment of lung and nasal dysbiosis.

Omnidirectional MRI Catheter Resonator for Interventional Procedures

This invention describes an orientation-independent device that can create bright and highly localized signal enhancement during magnetic resonance imaging.

Mid-pregnancy Serum Biomarkers for Predicting Preterm Birth

This mid-pregnancy serum biomarker test can accurately and effectively identify pregnancies that will deliver before 32-weeks of gestation.

Novel Method Of Imaging Infection Using Radiotracers

UCSF researchers have invented novel radiotracers that allow imaging of both gram-positive and gram-negative bacteria infections using positron emission tomography (PET) to detect spread of infection and to distinguish that from other mimics.

Novel Method for Finding Low Abundance Sequences By Hybridization

This invention describes a novel method for enriching rare sequences in nucleic acid libraries.

Cell Aging Measured by Telomere Length and Telomerase Activity as a Diagnostic and Prognostic Biomarker of Major Depressive Disorder

This invention describes a new way to predict response to antidepressants in patients with Major Depressive Disorder (MDD) and the likelihood of developing the disease by measuring telomere length and telomerase activity.

A Blood-based Diagnostic Test for Early Stage Detection of Autism Spectrum Disorders (ASD)

A revolutionary blood-based diagnostic test measures three kinase signaling pathway activities to determine the likelihood of the patient having ASD at an early stage.

RAPID Non-invasive Diagnostic for Planktonic and Biofilm Fungal Infections

UCSF researchers have developed a non-invasive test for the rapid diagnosis of Candida albicans infections in both planktonic and biofilm form.

Molecular Diagnosis And Classification Of Malignant Melanoma

These novel sets of biomarkers predict the five year survival rate of melanoma patients.

A Novel Therapeutic Target and Diagnostic/Prognostic Marker for Lung Adenocarcinoma

This invention identifies a novel non-coding RNA (ncRNA) transcript as a potential diagnostic and prognostic marker for lung adenocarcinoma. Furthermore, inhibitors of this novel ncRNA might hold therapeutic potential.

Rapid Structure-guided Generation of Antibodies for Detecting Protein Phosphorylation Modifications

This invention is a rapid, robust method to generate high-quality, renewable antibodies specific to protein phosphorylations via antibody scaffolds.

A Gene Expression Panel For Diagnosis Of Ebola Virus Infection

This invention identifies a novel host gene expression panel to screen for the Ebola virus in pre-symptomatic patients.

Double Tuned Phase Array Coils for Simultaneous Proton and Heteronuclear MRI

UCSF researchers have developed a new double-tuned radiofrequency (RF) coil for simultaneous proton and heteronuclear magnetic resonance imaging (MRI). This novel coil design allows for independent frequency adjustments of the two magnetic resonance modes.

Rapid and Sensitive Diagnostic for Blood Clot Formation and Cardiovascular Disease

This advanced, quantitative, real-time, peptide-based diagnostic technology can provide fast, safe, and highly specific diagnosis, monitoring, and imaging of thrombotic events such as pulmonary embolism, deep vein thrombosis, myocardial infarction and stroke and indirect thrombotic diseases such as cancer and diabetes.

Plasma Biomarkers for Monitoring Cancer Chemotherapy Efficacy

Highly sensitive protein biomarkers that can be used to monitor the extent of apoptosis in order to optimize chemotherapy regimen in cancer patients

Generation of Metagenomic Next-generation Sequencing Libraries Optimal for Long-read Sequencing Technologies

This invention is a technology that prepares physical long-read fragments from short-read metagenomic libraries that can be sequenced quickly and efficiently using long-read next-generation sequencing technologies. As of this time, there are no existing commercially available technologies that can offer this advantage.

Methods for Real-Time Sequencing Analysis of Infectious Diseases

A novel point-of-care technology enables real-time analysis and visualization of metagenomic sequence data for pathogen detection using a device that generates long sequencing reads at low cost and high speed with minimal sample preparation and instrumentation.

Novel Predictive Cancer Biomarker for PARP lnhibitors in Cancer Treatment

This novel biomarker predicts the treatment response of PARP inhibitors in cancer patients.

IMMUNOGENIC PEPTIDES OF AQP4 FOR THE DIAGNOSIS AND TREATMENT OF NEUROMYELITIS OPTICA (NMO)

This invention identifies the exact regions within AQP4 that trigger an immune response, which provide promising therapeutic potential for the diagnosis and treatment of Neuromyelitis Optica.

HIGHLY SPECIFIC DIAGNOSTIC CLASSIFIERS OF ENDOMETRIOSIS

This invention provides a non-invasive method to detect endometriosis in women through the use of novel diagnostic biomarkers that detect the presence, absence, and/or severity of endometriosis.

Methods And Reagents For Live Biopsy

This invention identifies a set of antibodies that allow direct imaging of immune cells in a tumor biospecimen.

Novel ELISA assay to detect SULF2 in patient samples

This ELISA technique detects Sulfatase2 (SULF2), an extracellular heparan sulfate-degrading enzyme that is overexpressed in many cancers. Furthermore, this technique can potentially serve as a diagnostic for cirrhosis.

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