Mid-pregnancy Serum Biomarkers for Predicting Preterm Birth

Tech ID: 27154 / UC Case 2016-048-0

Invention Novelty

This mid-pregnancy serum biomarker test can accurately and effectively identify pregnancies that will deliver before 32-weeks of gestation.

Technology Description

Currently, there is no comprehensive and reliable test that can be performed in mid-pregnancy to predict preterm birth. Researchers at University of California, San Francisco have developed an early spontaneous preterm birth (sPTB) diagnostic test that combines three maternal characteristics and 14 serum markers related to placental and immune system function. The markers in this model were identified from the study of more than 346 singleton pregnancies. This highly accurate test will allow the early identification of pregnant women at risk for pre-term birth that would benefit from existing and low-cost interventions to delay delivery or improve fetal outcomes such as low-dose aspirin treatment.

Looking for Partners

To develop & commercialize a diagnostic that would help mid-pregnant women prevent pre-term birth.

Stage of Development

Proof of Concept

Related Materials

  • Publications upon request

Data Availability

Under CDA / NDA

Patent Status

Country Type Number Dated Case
Australia Published Application 2016-048
Canada Published Application 2016-048
European Patent Office Published Application 2016-048
Japan Published Application 2016-048
Patent Cooperation Treaty Published Application 2019068092 04/04/2019 2016-048
Patent Cooperation Treaty Published Application WO2017136799 08/10/2017 2016-048

Additional Patent Pending


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  • Jelliffe, Laura
  • Murray, Jeffrey C.
  • Ryckman, Kelli

Other Information


Serum Biomarkers, Therapeutic intervention, Maternal characteristics, Early spontaneous preterm birth (sPTB)

Categorized As