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TRM: Mouse Mammary Tumor Virus-PyMT Transgenic Mice

Transgenic mouse models that develop spontaneous mammary adenocarcinomas have proven valuable in revealing molecular mechanisms underlying tumorigenesis and metastasis . Models target specific pathways depending on the transgene being expressed under the control of the mouse mammary tumor virus long terminal repeat (MMTV-LTR) or whey acid protein (WAP) mammary gland promoters and thereby replicate genetic defects in subsets of human tumors.

Microbiome-Based Intervention For Intrauterine Growth Restriction

UCLA researchers in the Department of Integrative Biology and Physiology have identified one of the underlying causes of intrauterine growth restriction, which may be treated with microbiome-based therapeutics.

Vaccines Against Herpes Simplex Virus Infection

Herpes simplex virus (HSV) infections affect billions of patients worldwide and can manifest its symptoms as painful blisters or ulcers at oral, ocular or genital locations. Symptomatic patients can currently only alleviate their pains with antiviral medication. These technologies propose a shift in focus toward novel protective epitopes as the foundation for new vaccines.

New Indication For GABA And Its Metabolism In Pre-Eclampsia

UCLA researchers in the Department of Obstetrics and Gynecology have developed a novel biomarker for pre-eclampsia diagnosis.

In vivo optical biopsy applicator of the vaginal wall for treatment planning, monitoring, and imaging guided therapy

Pelvic floor disorders (PFDs) afflict nearly 25% of all women and carry a host of symptoms that can drastically reduce quality of life. Despite their prevalence, the complex and varied nature of such PFDs make them difficult to diagnose and treat. Researchers at UCI have developed an entirely integrated system that, for the first time, provides real-time monitoring of the vaginal wall tissue during diagnosis and treatment, allowing for more thorough diagnoses and more effective treatment methods.

Vaccine Against Herpes Simplex Virus Infection

Herpes simplex virus (HSV) infections affect billions of patients worldwide and can manifest its symptoms as painful blisters or ulcers at oral, ocular or genital locations. Symptomatic patients can currently only alleviate their pains with antiviral medication. This technology proposes a shift in focus toward novel protective epitopes as the foundation for new vaccines.

Novel Anti-Bacterial, Anti-Fungal Nanopillared Surface

Medical devices are susceptible to contamination by harmful microbes, such as bacteria and fungi, which form biofilms on device surfaces. These biofilms are often resistant to antibiotics and other current treatments, resulting in over 2 million people per year suffering from diseases related to these contaminating microbes. Death rates for many of these diseases are high, often exceeding 50%. Researchers at UCI have developed a novel anti-bacterial and anti-fungal biocomposite that incorporates a nanopillared surface structure that can be applied as a coating to medical devices.

Sieve Container For Contactless Media Exchange For Cell Growth

Media that contains nutrients and growth factors is necessary to grow all types of cells, a process that is widely used in many fields of research. Such media should be routinely changed either to different media or a fresh batch of the same media. This change currently involves either using a pipette to transfer cells from their current dish of media to a new dish, or aspirating the media out of the dish and replacing it with new media. Both methods have inherent risks to stressing and damaging the cells. Researchers at UCI have developed a unique dish for growing cells that allows for safer aspiration of the old media, which reduces stress and damage to the cells.

Breast Lesion Characterization Using Contrast Mammography

Breast cancer is the most common cancer in women in the U.S. As with any cancer, early detection and treatment is critical in minimizing the severity of the tumor and risk of death. Researchers at UCI School of Medicine have developed a novel contrast-enhanced mammography technique capable of distinguishing between benign and malignant lesions in breast tissue.

Label Free Assessment Of Embryo Vitality

Researchers at UC Irvine developed an independent non-invasive method to distinguish between healthy and unhealthy embryos.

Enhanced Cell/Bead Encapsulation Via Acoustic Focusing

The invention consists of a multi-channel, droplet-generating microfluidic device with a strategically placed feature. The feature vibrates in order to counteract particle-trapping micro-vortices formed in the device. Counteracting these vortices allows for single particle encapsulation in the droplets formed by the device and makes this technology a good candidate for use in single cell diagnostics and drug delivery systems.

Mid-pregnancy Serum Biomarkers for Predicting Preterm Birth

This mid-pregnancy serum biomarker test can accurately and effectively identify pregnancies that will deliver before 32-weeks of gestation.

A Mouse Model of Human Papillomavirus (HPV) infection for Drug Discovery

UCSF researchers have generated and validated a K14-HPV16 transgenic mouse model, in which transgene expression produces neoplastic progression that fully resembles the gynecological and other epithelial dysplastic lesions induced by high risk HPVs. This model offers an invaluable tool for studying HPV infection and developing new drugs for HPV treatment.

A non-destructive method of quantifying mRNA in a single living cell

The detection of levels of messenger RNA (mRNA), the molecule used by DNA to convey information about protein production, is a very important method in molecular biology. Current detection strategies, such as Northern Blotting and RT-PCR, require destruction of the cell to extract such information. Researchers at the University of California, Irvine have developed a method to non-destructively assess mRNA levels in a single living cell.

Early Detection of Ovarian Cancer Using Markers to Short Chain Carbohydrates

Researchers at the University of California, Davis have developed a unique method for early detection in ovarian cancer using chemical markers corresponding to short chain carbohydrates.

Radioactive Soft Tissue Filler For Brachytherapy

The invention is a radioactive gel for treatment of soft tissue cancers. This compliant, biocompatible gel infused with radioactive elements is meant to provide cosmetic tissue restoration as it fills out cavities resulting from tumor removal (e.g. lumpectomies). Once in the cavity, the material delivers precisely dosaged and localized radiation therapy (also known as brachytherapy) to the affected tissues around it.

Patient-Specific Ct Scan-Based Finite Element Modeling (FEM) Of Bone

This invention is a software for calculating the maximum force a bone can support. The offered method provides an accurate assessment of how changes in a bone due to special circumstances, such as osteoporosis or a long duration space flight, might increase patient’s risk of fracture.

A Method For Determining Characteristic Planes And Axes Of Bones And Other Body Parts, And Application To Registration Of Data Sets

The invention is a method for deriving an anatomical coordinate system for a body part (especially bone) to aid in its characterization. The method relies on 3-D digital images of an anatomical object, such as CT- or MR-scans, to objectively, precisely, and reliably identify its geometry in a computationally efficient manner. The invention is a great improvement over the current practice of subjective, user-dependent manual data entry and visualization of bones and organs. The applications for well-defined anatomical coordinate systems include robotic surgeries, models for bone density studies, and construction of statistical anatomical data sets.

Compositions and Methods for Treating Estrogen-Receptor Associated Conditions

 Menopausal hormone therapy (MHT) reduces the risk of developing osteoporosis, fractures, obesity and type II diabetes, yet it is only approved for short-term therapy due to the serious risks associated with long-term therapy (e.g., increased risks of breast cancer, stroke, and heart attacks). To target these indications associated with menopause, it will be necessary to develop safer MHT regimens that can be used as continuous therapy. There are two current strategies for developing safer MHT:  First, estrogens have been combined with the selective estrogen receptor modulator, bazedoxifene, which prevents estrogen binding to ERα, thereby blocking the proliferative effects on the uterus. However, this combination is approved only for short-term treatment of hot flashes. Second, ERβ-selective agonists have been developed; unfortunately, ERβ agonists may not be effective for osteoporosis, weight gain or diabetes because ERα is the major active ER in both bone and adipose tissue.   UC Berkeley researchers have discovered a compound that acts as a reprogramming ERα coligand that could improve safety profile of MHT. The compound was found to bind of to a different site on ERα and reprograms the actions of estradiol. This compound represents a new class of drugs that can be combined with existing estrogens to produce safer MHT regimen for long-term treatment to safely prevent chronic diseases associated with menopause. 

Second-Generation Estrogen Receptor Down-Regulators for Medical Therapy

UCLA researchers in the School of Medicine have developed a series of novel estrogen receptor antagonists for breast cancer therapy.

HIGHLY SPECIFIC DIAGNOSTIC CLASSIFIERS OF ENDOMETRIOSIS

This invention provides a non-invasive method to detect endometriosis in women through the use of novel diagnostic biomarkers that detect the presence, absence, and/or severity of endometriosis.

Automated CD Microfluidic Device for Cell Culture

An automated media exchange CD microfluidic device that may be used for cell culture or in vitro fertilization.

Wrinkled Metal Film Strain Gauge For Fetal Movement Detection

There is great importance to monitoring fetal movement because it is an indicator of fetal health. A medical device has been developed for continuous monitoring of fetal movement outside the clinic. The easy to wear device will give mothers’ reassurance that they are doing everything they can to monitor their baby’s health.

Ultra-sensitive androgen assay

This invention is a novel assay to detect and quantify androgen levels, as low as 1.5 ng/dl, in blood or serum samples.

Bladder Denervation For Treating Overactive Bladder

The device and method uses a technique through a vaginal probe to cause denervation of the overactive bladder. The vaginal probe denervates the pelvic nerve supply to the overactive bladder. Women with high urine frequency could be candidate for this simple procedure.

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