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Ultra-High Resolution Multi-Platform Heterodyne Optical Imaging

Researchers at the University of California, Davis have developed a new technique for achieving ultra-high resolution heterodyne synthetic imaging across multiple platforms (e.g. multiple satellites) using optical frequency comb sources.

Transabdominal Fetal Blood Oximetry

Researchers at the University of California, Davis have developed a method and apparatus for clinical-grade transabdominal fetal blood oximetry.

Genetically Encoded Fluorescent Sensors for Probing the Action of G-Protein Coupled Receptors (GPCRs)

Researchers at the University of California, Davis have developed a genetically encoded fluorescent sensor toolbox for the probing of G-protein coupled receptors.

Novel Applicator Using FTA Paper to Collect Touch DNA

Researchers at the University of California, Davis have developed a novel approach to an applicator designed to expedite and increase the efficiency of the DNA collection process at crime scenes.

Resolution Enhancement Method For Mm-Wave/Terahertz Imaging

UCLA researchers in the Department of Electrical Engineering have developed an imaging method based on low-cost CMOS process technologies showing enhanced resolution as high as 1.4THz.

Apparatus And Method For Optically Amplified Multi-Dimensional Spectrally Encoded Imaging

Scientists at UCLA have developed an advanced optical imaging technique that uses spectral brushes to capture image data across an entire sample area at once, a technique that enables faster imaging and higher sensitivity over current methods.

Novel Contrast Enhancement for Detection of Amyloid Beta Peptides using MRI, EPR, PET, and ESRM

Researchers at the University of California, Davis have developed nitroxide-coupled amyloid agents to produce contrast enhancement for amyloid beta peptide (Abeta) detection using MRI, EPR, PET, and ESRM.

Multiple in vivo tissue chromophores

The field of the invention generally relates to methods and devices used in diffuse optical spectroscopy. More specifically, the field of the invention generally relates to broadband diffuse optical spectroscopy methods and devices which are able to dynamically monitor multiple in vivo tissue chromophores. A device and method utilizes a broadband diffuse optical spectroscopy (DOS) system to dynamically calculate the concentrations of multiple chromophores in vivo using a non-invasive probe. The device and method permit dynamic monitoring of multiple in vivo tissue chromophores non-invasively with sensitivities necessary for effective therapeutic monitoring. The device includes a probe containing first and second source optical fibers as well as first and second detector optical fibers. The probe is placed adjacent to a sample of interest and detects reflected light which is passed to a proximally located detector and spectrometer. The concentrations of multiple chromophores are determined in real time. In a preferred embodiment, the multiple tissue chromophores include at least two of methemoglobin (MetHb), deoxyhemoglobin (Hb-R), oxyhemoglobin (Hb-O2), water (H2O), and methylene blue (MB). The device and method can be used quantify and monitor methemoglobin formation in subjects suffering from methemoglobinemia.

New label-free method for direct RNase activity detection in biological samples

Researchers at the University of California, Davis have developed a new and simple, label-free method to detect milligram levels of RNase activity in undiluted biological samples that is selective, accurate and scalable


Sucralose has become widely used as an artificial sweetener due in large part that it has low caloric content and is 600 times sweeter than table sugar (sucrose). Due to its resistance to metabolic degradation, sucralose can also be used as a marker for noninvasively assessing gastrointestinal small intestine or colonic permeability. This urinary marker is traditionally analyzed by time consuming and expensive methods, such as high performance liquid chromatography coupled to mass spectrometry or evaporative light scatter as the detectors. We have developed an alternative methodology of using a chemical-fluorescent technique for rapid analysis of halogenated disaccharides, such as sucralose.

External Cavity Laser Based Upon Metasurfaces

UCLA researchers in the Department of Electrical Engineering have developed a novel approach for terahertz (THz) quantum-cascade (QC) lasers to achieve scalable output power, high quality diffraction limited, and directive output beams.

An Integrated Microfluidic Platform For Selective Extraction Of Single-Cell mRNA

The invention is a high-density, single-cell trapping array. A specialized probe tip can be precisely manipulated to non-destructively collect targeted intracellular material from the trapped cells for measurements. Due to the non-destructive nature of the invention, the integrity and function of the trapped cells can be preserved and they can be monitored over time to better understand disease processes.

A Method For Accurate Parametric Mapping Based On Characterization Of A Reference Tissue Or Region

UCLA researchers in the Department of Radiological Sciences have developed a method to address the issue of B1+ field inhomogeneity that is becoming a persistent problem in higher field strengths. 

Individual Identity Verified Through Device-Free, WiFi Based Framework

Researchers at the University of California, Davis have developed a device-free, WiFi based framework that can isolate individual identity, from a small group of users, simply by observing variations in WiFi signals through a user’s gait.

Direct Optical Visualization Of Graphene On Transparent Substrates

96 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:Calibri; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} The ∼10% optical contrast of graphene on specialized substrates like oxide-capped silicon substrates, together with the high-throughput and noninvasive features of optical microscopy, have greatly facilitated the use and research of graphene research for the past decade.  However, substantially lower contrast is obtained on transparent substrates. Visualization of nanoscale defects in graphene, e.g., voids, cracks, wrinkles, and multilayers, formed during either growth or subsequent transfer and fabrication steps, represents yet another level of challenge for most device substrates.     UC Berkeley researchers have developed a facile, label-free optical microscopy method to directly visualize graphene on transparent inorganic and polymer substrates at 30−40% image contrast per graphene layer.  Their noninvasive approach overcomes typical challenges associated with transparent substrates, including insulating and rough surfaces, enables unambiguous identification of local graphene layer numbers and reveals nanoscale structures and defects with outstanding contrast and throughput. We thus demonstrate in situ monitoring of nanoscale defects in graphene, including the generation of nano-cracks under uniaxial strain, at up to 4× video rate.  

Nuclear Magnetic Resonance System for Determining Oil and Water Compositions in Drilling Mud

Researchers at the University of California, Davis have developed a nuclear magnetic resonance (NMR) system and method for determining oil and water compositions in drilling mud.

Method To Probe Bulk And Surface States In Thermoelectrics And Topological Materials

Researchers in the department of Chemistry and Biochemistry at UCLA have developed a non-invasive, site-specific method to probe the electronic structure of both surface and bulk states within thermoelectric and topological insulator materials.

OptoPlates: Programmable LED Devices for Tunable Illumination of Tissue Culture Plates

A programmable, standalone LED array that unlocks new potential for both real-time activation of proteins and visualization of cells during high-throughput screening. This device can be used in such advanced research techniques as optogenetic activation, photoconversion, photobiology, and drug screening.

Pseudo Light-Field Display

Creating correct focus cues (blur and accommodation) has become a critical issue in the development of the next generation of 3D displays, particularly head-mounted displays.  Withough correct focus cues, current 3D displays create undue visual discomfort and reduce visual performance.  Current attempts to solve the focus cues problem are limited in their practical use.  For example, volumetric displays are limited because the viewable scene is restricted to the size of the display volume.  Multi-plane displays require very accurate alignment between the display and the viewer’s eyes.  Light field displays often require demanding resolution requirements and computational workload.   Researchers at UC Berkeley have developed a system and method to correct focus cues with a conventional display, a dynamic lens in front of each eye, and a method to measure the current focus or an estimate of the current focus of each eye.  Most of the system components are currently commercially available and the technology solves the speed and resolution problems in current light field displays. 

Shaped Piezoelectric Micromachined Ultrasonic Transducer Device

Piezoelectric Micromachined Ultrasonic Transducers (pMUTs) have attracted industry attention for their good acoustic matching, small geometry, low cost-by-batch fabrication, and compatibilities with CMOS and consumer electronics. While planar pMUTs have reasonable performance over bulk piezoelectric transducers, certain deficits remain in terms of coupling and acoustic pressure outputs, DC displacements, bandwidth, and power consumption. To address these deficiencies, researchers at the University of California, Berkeley, have developed a next generation of shaped pMUTs which are no longer fully defined by resonance frequency and can accommodate larger pressure outputs and bandwidths. This new pMUT apparatus can significantly boost overall performance while dramatically reducing power as compared to flat diaphragm state-of-the-art pMUTs.

Apparatus and Method for 2D-based Optoelectronic Imaging

The use of electric fields for signaling and manipulation is widespread, mediating systems spanning the action potentials of neuron and cardiac cells to battery technologies and lab-on-a-chip devices. Current FET- and dye-based techniques to detect electric field effects are systematically difficult to scale, costly, or perturbative. Researchers at the University of California Berkeley have developed an optical detection platform, based on the unique optoelectronic properties of two-dimensional materials that permits high-resolution imaging of electric fields, voltage, acidity, strain and bioelectric action potentials across a wide field-of-view.

Degraded/Distorted Image Restoration

Brief description not available

Software for Differential Dynamic Microscopy (DDMCalc)

A MATLAB code for performing differential dynamic microscopy (DDM).

Dry-Eye Formulation

The sensation of ocular discomfort commonly referred to as “dry eye” can be caused by various factors. The principal causative factors are (a) increased tear-evaporation rates attributable to meibomian gland dysfunction and insufficient/unbalanced tear-lipid films; (b) inadequate tear-aqueous production attributable to aging, medical procedures performed on the cornea (e.g., LASIK), or other general health conditions (e.g., autoimmune diseases); (c) environmental irritants (e.g., dust, smoke, wind, sun, or low humidity); and (d) eye strain attributable to extended viewing of computer monitors or other working environment-related factors. There are many different artificial-eye drops marketed and prescribed or recommended by medical practitioners to decrease dry-eye sensations. Unfortunately, all provide only short-term or no effects at all on tear-film stability and evaporation rates. Moreover, many artificial-tear formulations contain petrochemicals, (e.g., mineral oil) which have nothing in common with natural lipids comprising human tear-lipid films and might be potentially harmful to the eye.   Researchers at UC Berkeley have developed bicontinuous microemulsion formulations capable of delivering the components necessary to counteract compromised stability of tear-lipid layers and thus enhance the stability of entire tear films. These bicontinuous microemulsion components disperse spontaneously into a physical state that makes the microemulsion completely miscible with both human tear aqueous and human tear lipids. The components of these microemulsions are chemically identical or very close to natural tear lipids and tear aqueous and thus are completely biocompatible with human tear films. The lipids used in this formulation are biodegradable, and human tear enzymes will be able to metabolize these bicontinuous microemulsion lipids.  

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