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Antibodies for the Detection of Toxoplasma Gondii Oocysts

Researchers at the University of California, Davis have developed the first monoclonal antibodies that recognize, bind to, and can be used to concentrate oocysts of Toxoplasma gondii.

Manufacturing of Tungsten Scandate Nano-Composite Powder via Sol-Gel Method for High Current Density and Long-Life Cathodes

The researchers at University of California, Davis have developed a new process for manufacturing tungsten scandate nano-composite powder that produces high current density and long-life cathodes for high-power terahertz vacuum electron devices. Scandate tungsten nano-composite cathodes enable advancement of microwave sources that bridge the "Terahertz gap."

Multi-Channel Microfluidic Piezoelectric Impact Printer

High-throughput, automated, large-scale microarray format assay in a short time frame and at low cost.

Electrical Transport Spectroscopy: An On-Chip Nanoelectronic Based Characterization Method

Researchers in the Department of Materials Science and Engineering at UCLA have recently developed electrical transport spectroscopy (ETS).

Measurement Of Blood Flow Dynamics With X-Ray Computed Tomography: Dynamic Ct Angiography

This invention identifies a method to accurately measure flow dynamics, such as velocity and volume, from Computed Tomography scans of blood vessels in a patient.

Beta-Amyloid Plaque Imaging Agents

Current imaging agents for labelling β-amyloid plaques and neurofibrillary tangles (NFT), which are indicators for Alzheimer’s disease, suffer from drawbacks such as (but not limited to) non-specific binding, low target to non-target ratio, instability, and inefficient labelling. Researchers at UC Irvine have developed an imaging agent and its derivatives for labelling β-amyloid plaques and NFTs that overcome these problems and also provide therapeutic properties in vivo for the neural tissues. The labelling agent also binds to norepinephrine transporters (NET) and are taken up into the cells via the NET, therefore serving as suitable agents for diagnostic and/or therapeutic purposes involving disorders or conditions associated with NET.

Lateral Cavity Acoustic Transducer Based Microfluidic Switch

The ability for on-chip particle/cell manipulation is important for microfluidic applications. Researchers at UC Irvine have developed a technology that exploits the phenomenon of acoustic microstreaming to manipulate fluid flow and suspended cells/particles in a microfluidic environment.

Multilayer High Density Microwells

Researchers at UC Irvine have developed high density, three dimensional (3D) micro-reactors for digital biology applications. The high-density imaging arrays overcome drawbacks associated with existing high density arrays fabricated on a single surface and the more recent 3D droplet emulsion arrays.

Integrative Approach for the Analysis and Visualization of Static or Dynamic Omic Data, Including Genomic, Proteomic, Gene Expression, and Metabolic Data

The technology is a method for analysis and mapping of a broad range of omic data.It features maps and visualizes interactions between omic data, such as how the circadian metabolome, transcriptome, and proteome operate in concert.With this technology, users can use non-public and public data, per tissue/organ data and data across multiple conditions.

Methods and Compositions for Determining Differences in Taste Perception

People vary dramatically in their taste perception. What one person perceives as mild and pleasant, another will perceive as aversively spicy. Perception of piquancy, sweetness, sourness, temperature, bitterness, and other components of taste all vary across individuals in this way. Some substances, such as cilantro and phenylthiocarbamide, are famously polarizing, producing perceptual experiences that differ radically across individuals. Yet there is no universal system for measuring taste perception; people have a sense for what they like, but they cannot measure it or communicate it to others precisely. This means, for example, that food providers are left almost entirely in the dark, forced to cater to the average and not the individual. To address this need, researchers at the University of California, Berkeley, have created methods and compositions for consumable products to measure individual differences in taste perception. This innovative approach could lead to new products in support of a universal system for measuring taste perception, with an opportunity for consumers and retailers to understand food and beverage preferences in more precise, quantitative terms.

Methods of Monitoring and Manipulating the Fate of Transplanted Cells

Tumor initiation and progression into metastasis are accompanied by complex structural changes in the extracellular matrix and cellular architecture that alters the stiffness in the microenvironment of the cell.

Methods And Utilizations For Tissue Staining And Digital Microscopy

The current state of the art in digital pathology is whole-slide imaging, in which tissues are fixed in formalin, processed and paraffin-embedded, cut, stained with standard reagents for tissue histochemistry, and placed on glass slides.  The glass slides are then scanned to create a digital image of the tissue.  Although this represents the current state-of-the-art, it is a very expensive, and time, and space-consuming process. 

Flowmax: A Computational Lymphocyte Phenotyping Tool For Deriving Cell Biological Insights From CFSE Flow Cytometry Time Courses (2012-234)

Lymphocyte population dynamics within the mammalian immune response have been extensively studied, as they are a predictor of vaccine efficacy, while their misregulation may lead to cancers or autoimmunity. A current experimental approach for tracking lymphocyte population dynamics involves flow cytometry of carboxyfluorescein succimidyl ester (CFSE)-stained cells. First introduced in 1990, CFSE tracking relies on the fact that CFSE is irreversibly bound to proteins in cells, resulting in progressive halving of cellular fluorescence with each cell division. By measuring the fluorescence of thousands of cells at various points in time after stimulation, fluorescence histograms with peaks representing generations of divided cells can be obtained. However, interpreting CFSE data confronts two challenges. In addition to intrinsic biological complexity arising from generation- and cell age-dependent variability in cellular processes, fluorescence signals for a specific generation are not truly uniform due to heterogeneity in (i) staining of founder population, (ii) dye partitioning during division, and (iii) dye clearance from cells over time. Thus, while high-throughput experimental approaches enable population- level measurements, deconvolution of CFSE time courses into biologically-intuitive cellular parameters is susceptible to misinterpretation.

Device for Monitoring Cerebrovascular Autoregulation

Cerebrovascular autoregulation (CVA) refers to the physiological mechanisms that maintain blood flow to the brain at an appropriate level during changes in blood pressure. CVA is a physiological phenomenon of importance to health and therefore, can be used for diagnostics of a very large number of diseases of the brain with a vascular component, such as atheroschelorotic plaque formation, acute hypertension, stroke and concussion. The devices currently used for CVA monitoring are complex, expensive and require an expert for use.   UC Berkeley researchers have developed a scientifically advanced and technologically simple device for monitoring CVA by using the transcranial transmission of very low energy, non-ionizing radiofrequency electromagnetic waves. The technology measures the amplitude and phase change between transcranial induction coils and can monitor in real time and without contact, stimulus triggered, CVA induced changes in the blood quantity and distribution in the brain. The simplicity of the technology makes it suitable for use without substantial medical training and can provide solutions to diagnostics of various diseases of the brain in rural and economically underdeveloped parts of the world. 

Predicting Metabolic Side Effects Of Transported Drugs

Drug clearance is the important process by which a drug and/or its metabolites are eliminated from an organism.  When drug clearance is excessive, efficacy of the drug may not be achieved; when drug clearance is inadequate, toxicity to the organism may result.  Members of the solute carrier (SLC) and ATP-binding cassette (ABC) “drug” transporter families  have  well-established roles in absorbing, distributing, and eliminating xenobiotics such as drugs. In addition, there is growing evidence for suggesting that these transporters also transport metabolites, nutrients, signaling molecules, and antioxidants at the organismal and cellular levels. Competition of drugs with metabolites at the level of transporters involved in absorption, distribution, and elimination of drugs and metabolites can lead to major metabolic side effects over the long term.  Owing to the tremendous clinical importance of these transporters, there is a need to combine metabolic reconstruction (systems biology) methods with computational (pharmaceutical) chemistry, as well as wet lab validation to study these transporters of the SLC and ABC family and drug-induced metabolic changes.

Zebrafish-based Analysis Platform (iZAP)

Animal testing is a vital part of neurological disorder research and drug discovery. One problem is tied to low throughput associated with common single-subject tracking and analysis. Another set of problems are related to the manual and invasive nature of animal-based test operations. To overcome these problems, researchers at the University of California, Berkeley have developed and demonstrated a zebrafish-based analysis platform (iZAP) for high-throughput, multichannel laboratory testing and research. The multi-fluidic platform system allows for simultaneous measurements of activity in many organisms at one time, including enhanced electroencephalography and electrocardiography. Berkeley’s iZAP holds promise in terms of faster and broader measurements, improved accuracy, and significantly lower cost per test than current market approaches.

Polypeptide-Based Vehicles for Intracellular Drug Delivery and Method of Generation

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering have developed a portfolio of polypeptide-based drug delivery systems and the processes for their generation. These delivery vehicles include polymeric vesicles, stabilized double emulsions, hydrogels, and new cell penetrating peptide (CPP) tags. These materials have applications toward pharmaceuticals, drug delivery, cosmetics, and personal care products.

Novel Multivalent Bioassay Reagents

The guiding principle for the creation of biomolecular recognition agents has been that affinity is essential for both strength and specificity.  Monoclonal antibodies, the dominant workhorse of affinity reagents, have mono-valent affinities in the uM-nM range with apparent affinities that can be sub nM with the bi-valency intrinsic in intact immunoglobulin structure.  The avidin-biotin interaction used ubiquitously for biomolecular assembly is femto-molar and both highly specific and essentially irreversible.  High affinity has been proclaimed the essential goal for the selection of useful specific aptamers, though there has been disagreement about a tight coupling of affinity and specificity.  

Ferrofluid Droplets to Locally Measure the Mechanics of Soft Materials

A technique and apparatus that can measure the mechanical properties of any kind of soft material, including complex fluids, living embryonic and adult tissues (such as skin), as well as tumors. 

Improved Cell Detection and Classification by Coded Node Pore Sensing

Particle isolation and particle screening are valuable techniques used in microfluidic chip analyses.  One problem is longer transit times in the microfluidic channel caused by certain interactions between particle-surface receptors and functionalized pore. Another problem is related to the accuracy in detecting specific particles of interest. To address these problems, researchers at the University of California, Berkeley have expanded their thinking in terms of signal processing and have demonstrated advanced particle screening by leveraging unique electrical current signatures. This discovery shows promise in terms of much higher-throughput detection and real-time cell classification even at low signal-to-noise ratio.

High-Throughput Lensfree 3D Tracking of Human Sperms

UCLA researchers have developed a lensfree technique to track three-dimensional trajectories of individual human sperms.

System for Patterned Illumination Microscopy

Existing structured illumination microscopy can increase the resolution of an image by a factor of 2, however, it requires expensive optical or mechanical devices (e.g., spatial light modulators, digital micromirror devices, or piezo translation stages).  Also, the existing movable patterned mask generated by the light interference using SLM or DMD suffers from hysteresis and repeatability problems due to mechanical motion.  UC Berkeley researchers have developed a computational illumination hardware and software system that can achieve pattern-shift on the object plane without mechanically switching the patterns and therefore without movement of any component.  The lensless system can be easily implemented into existing microscopes without extra hardware can can be extremely fast and suitable for real-time imaging applications.     

Self-Assembled Modified Beta Solenoid Protein Scaffolds for Devices And Materials

Available for licensing are patent rights in novel and versatile beta solenoid proteins that are useful as scaffolds for nanoparticle assembly, photocatalytic devices, thermoelectric devices, passive absorption of small atoms or molecules, cement additive, heavy element remediation, heavy element absorption, and as biological catalysts.

High Resolution Depth of Interaction Gamma Radiation Detector

Researchers at UCLA have developed a method for improving the spatial resolution and sensitivity of gamma radiation detection for positron emission tomography (PET).

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