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Bioorthogonally-Engineered Extracellular Vesicles for Applications in Detection and Therapeutic Delivery

Extracellular vesicles (EVs) are promising as drug delivery carriers because they are inherently biocompatible, It would be desirable to efficiently, specifically, and rapidly change the EVs surface presentation to program the interactions with its target cells. Inventors at UC Irvine have developed a strategy for functionalizing the cellular membranes of EVs with precision and ease.

Platform for predicting a compound’s cardioactivity

The invention is a platform that combines a screening system and machine learning algorithms to investigate and report the cardio-activity related information of a certain compound. Through screening cardiac tissue strips, the platform determines whether a compound is cardio-active or not, as well as the associated cardio-active mechanism based on a drug library that is automatically developed. Such information is crucial for the drug development process, especially for evidence based decisions.

Biomarkers for Port Wine Stain and Related Syndromes

Researchers at the University of California, Irvine (UC Irvine) have discovered specific biomarkers that will enable innovations in diagnosis, prognosis, monitoring, and therapy of PWS and other related syndromes.

Portable waterborne pathogen detector

The inventors at the University of California, Irvine, have developed an automated, easy-to-use digital PCR system that can be used at the time of sample collection, making it highly effective in microbial pathogen analysis in resource-limited settings and extreme conditions.

Predictive Optimization Of Pharmeceutical Efficacy

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a machine learning platform to virtually screen combinatorial drug therapies.

Computational Out-Of-Focus Imaging Increases The Space-Bandwidth Product In Lens-Based Coherent Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a wide-field and high-resolution coherent imaging method that uses a stack of out-of-focus images to provide much better utilization of the space-bandwidth product (SBP) of an objective-lens.

Sparsity-Based Multi-Height Phase Recovery In Holographic Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a sparsity-based phase reconstruction technique implemented in wavelet domain to achieve more than 3-fold reduction in the number of holographic measurements for coherent imaging of densely connected samples with minimal impact on the reconstructed image quality.

Single Fiber-Based Multimodal Biophotonic Imaging and Spectroscopy Platform

Researchers at the University of California, Davis have developed a highly flexible and reconfigurable optical imaging and spectroscopy platform.

Simple Low Cost Micro Pre-Concentrator for Gathering Gas-Phase Samples

Researchers at the University of California, Davis have developed a device for measuring preconcentration of gas samples, particularly involving detection using aerial systems.

Query-Based Graph Data Reduction

The invention is a set of algorithms that can reduce the amount of graph data for specific applications, based on the type of queries that the graph data needs to answer. Reducing graph data size for certain applications allows them to be run efficiently on devices with limited storage and/or bandwidth.

Integrated Electrowetting Nanoinjector and Aspirator

Gene therapy applications necessitate cell transfection techniques for delivering biomaterial into multiple or a single cell(s). The global market for transfection technologies can be worth more than half a billion by 2017. Current viral and chemical transfection techniques have limited ease of fabrication, transfection efficiency, dosage control, and cell viability. The invention discloses a simple yet efficient technique for nanoinjection of material into a single cell with high transfection efficiency, controlled dosage delivery, and full cell viability.

High-Efficiency One-Cell-One-Bead Encapsulation In Droplets

A high-efficiency single-cell droplet encapsulation method to improve single cell pharmacological assay throughput.

Methods for Generating Analogs of Coenzyme A for In Vivo and In Vitro Cellular Labeling

Selective chemical control of biochemical processes within a living cell enables the study and modification of natural biological systems in ways that may not be obtained through in vitro experiments. Accordingly, access to promiscuous metabolic pathways has provided a unique chemical entry into small molecule engineering in vivo. A method for covalent reporter labeling of carrier proteins using permissive phosphopantetheinyltransferase (PPTase) enzymes and reporter-labeled coenzyme A (CoA) has been commonly used but has been limited to in vitro and cell-surface protein labeling, as CoA derivatives have not been shown to penetrate the cell.

Non-Human Primate Adenovirus Model of Human Respiratory Disease

Researchers at the University of California, Davis have developed a model of human respiratory disease using a titi monkey adenovirus.

Versatile Labeling of Protein N-Termini for Site-specific Bioconjugation

Improved subtiligase variants allow broad and versatile site-specific chemical modification or conjugation of proteins on their N-termini.

Novel Inhibitors of Mitochondrial Electron Transport

Researchers at the University of California, Davis have discovered a class of compounds that both bind to a unique newly-discovered binding site in respiratory complex III and act as inhibitors of electron transport for use as mitochondrial anti-cancer drugs.

Sieve Container For Contactless Media Exchange For Cell Growth

Media that contains nutrients and growth factors is necessary to grow all types of cells, a process that is widely used in many fields of research. Such media should be routinely changed either to different media or a fresh batch of the same media. This change currently involves either using a pipette to transfer cells from their current dish of media to a new dish, or aspirating the media out of the dish and replacing it with new media. Both methods have inherent risks to stressing and damaging the cells. Researchers at UCI have developed a unique dish for growing cells that allows for safer aspiration of the old media, which reduces stress and damage to the cells.

An Efficient E-Cigarette Aerosol Generation And Exposure System For Rodents

UCLA researchers have developed an efficient electronic cigarette aerosol generator and exposure system for use in mice to study the health effects of electronic cigarette aerosol.

Scanning Method For Uniform, Normal-Incidence Imaging Of Spherical Surface With A Single Beam

UCLA researchers have created a method that achieves uniform normal-incident illumination of a spherical surface by first projecting the sphere onto a Cartesian plane and then raster scanning it using an illuminating beam. This allows the scanned object, the illumination source, and the detector to remain stationary.

Estimation Of Contrast Concentration From Angiograms In Presence Of Vessel Overlap

UCLA researchers have developed an image processing technique for quantitative measurement of brain hemodynamics using x-ray digital subtraction angiography (DSA) images. 

Pixel Super-Resolution Using Wavelength Scanning

UCLA researchers have developed a novel way to significantly improve the resolution of an undersampled or pixelated image.

Single Molecule Imaging and Sizing of DNA on a Cell Phone

UCLA researchers in the Department of Electrical Engineering have developed a light-weight and cost-effective fluorescence microscope installed on a cell phone.

Microbial Mediators Of The Beneficial Effects Of The Ketogenic Diet

UCLA researchers have identified a strategy to manipulate the gut microbiome to mimic the effects of a ketogenic diet, as a treatment for CNS disorders and metabolic diseases.

Process For Sorting Dispersed Colloidal Structures

Researchers from the Chemistry and Biochemistry department at UCLA have developed method of separating and/or sorting specific target structures from other non-target structures in a complex mixture using custom-made target-specific colloidal particles.

Nucleic Acid Tetramers For High Efficiency Multiplexed Cell Sorting

UCLA researchers in the Departments of Medicine and Pharmacology have a highly specific method of sorting cells by using multiplexed tetramers with unique DNA-oligomer signatures.

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