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Programmable Peptide Nucleic Acid-Based Nanoplatform for Customizable Drug Delivery
Researchers at the University of California, Davis have developed a peptide nucleic acid-based system enabling precise and customizable delivery of antigens, adjuvants, and targeting molecules for improved cancer immunotherapy.
1-(Benzo[1,2-b:4,5-b']Difuran-4-yl)alkyl-2-amines and 1-(2,3,6,7-Tetrahydrobenzo[1,2-b:4,5-b']Difuran-4-yl)butan-2-amines as Serotonin Receptor Modulators for Neurodegenerative Disorders
Researchers at the University of California, Davis have developed novel serotonin receptor modulators designed as mixed 5-HT2A/2C partial agonists that demonstrate promising disease-modifying potential for Parkinson’s Disease with improved safety and efficacy.
Genomic Destructive CRISPR Guide RNAs
Brief description not available
Reusable, Sterilizable Surgical Instruments for Deployment of Neuropixels Probes in the Operating Room
Researchers at the University of California, Davis have developed a system of reusable, sterilizable 3D-printed surgical tools that enables safe, precise intraoperative deployment of Neuropixels probes within standard neurosurgical workflows.
Using Class I Lasso Peptides to Inhibit the Bacterial Type III Secretion System
Antibiotic resistance is a major issue in infectious disease treatment and prevention. In bacteria, the type III secretion system (T3SS) secretes effector proteins in the host cell, allowing the pathogen to infect. The T3SS is largely found on pathogens and not beneficial bacteria, so targeting the T3SS might have an advantage over using classic antibiotics, which disturb the beneficial human microbiome.
Arg Accelerates Proximity-Enabled Sufex Reaction Rate In Proteins
Improvement Of Glycemic Control Through Beta-Cell Administration Of Mir192
AAV-Based Gene Therapy for Glioblastoma Treatment Using Interferon Cytokines
Enhancing Cancer Immunotherapy with Modified Adaptor Protein and CAR-NK Cell Technology
Next-Generation Monoclonal Antibody Therapy Targeting High-Risk Tumors
Affinity-Matured Anti-Cd72 Nanobodies For Next-Generation CAR-T Immunotherapies
Vaccines Using Macrophage Suppression
Researchers at the University of California, Davis have developed a technology that introduces vaccines that express macrophage-suppressing molecules to significantly enhance inflammatory T-cell functions for improved immune responses.
Lung-Targeted Cell-Based Therapies for Inflammatory Disease and Cancer
Innovative T Cell Gene Editing System for Enhanced Cancer Immunotherapy
Dual Modality Radionuclide-Antibody Drug Conjugate for Advanced Prostate Cancer and Multiple Myeloma
Targeting Tumor-Associated Macrophages to Overcome Immunotherapy Resistance
Dual-Antigen Targeting CAR-T Therapy for Acute Myeloid Leukemia (AML)
A Novel In Vivo Genome-Wide CRISPR Screening Platform for Enhancing T Cell Immunotherapies in Solid Tumors
A Novel Approach to Overcome T Cell Exhaustion for Enhanced Anti-Tumor Activity
Macrophage Targeting Peptides - Peptide Sequences that are Specific to M1 And M2 Macrophages for Application in Molecular Imaging and Therapy
Researchers at the University of California, Davis have developed isolated peptides that selectively bind M1 and M2 macrophages to enable precise diagnosis and targeted treatment of macrophage-associated diseases, including cancer.
Cationic Silyl-Lipids for Enhanced Delivery of Anti-viral Therapeutics
Researchers at the University of California, Davis have developed an advancement in the field of healthcare technology, specifically in the development and application of silyl lipids for RNA vaccines.
Silyl-lipid N-acyl L-homoserine Lactones (AHLs) as Quorum Sensing Molecules (for Biofilms)
Researchers at the University of California, Davis have developed a potential therapeutic strategy aiming at disrupting intercellular communication of pathogens using quorum sensing molecules and silicon-based pharmacophores.
Silyl-lipid Cannabinoids with Enhanced Biological Activity
Researchers at the University of California, Davis have developed a therapeutic use of cannabinoids for the treatment of Neurodegenerative Disorders (NDDs).
Nanoplatform for Cancer Therapy
Researchers at the University of California, Davis have developed a nanoparticle system combining photothermal therapy and chemotherapy for enhanced cancer treatment.
Intranasal Delivery of Allopregnanolone
Researchers at the University of California, Davis have developed non-invasive methods for intranasally delivering the drug allopregnanolone.