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Method For Detecting Protein-Specific Glycosylation

O-GlcNAc modification is a common form of post-translational modification that mediates cellular activity and stem cell programming by modifying transcription factors. Multiple human diseases, including cancer and diabetes, have been linked to aberrant O-GlcNAcylation of specific proteins.Despite the importance of this modification, current methods for detection require advanced instrumentation and expertise as well as arduously enriched or purified samples. The “Glyco-seq” method developed by UC Berkeley researchers is highly sensitive, easy to use, and enables O-GlcNAc detection on proteins of interest in cell lysate. 

Fluid management device / fluid delivery system

Researchers at UC Irvine have developed a fluid delivery device. This delivery device simplifies the process of intravenous drug delivery to allow for an automated, efficient, and error free intravenous drug administration.

Novel Molecular Markers for Acne Diagnosis and Treatment

The Li group at UCLA has defined sets of biomarkers that can be used for the molecular diagnosis of acne, as well as a subtype of acne that is induced by high vitamin B12 levels in the host organism. These novel biomarkers have the potential to definitively differentiate acne from other skin diseases and aid medical practitioners in determining the most effective, personalized treatment for patients. They may also be used to design new treatments for acne.

Novel Gene Delivery Approach for Controlled and Sustained Transfection of Cells

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a novel hydrogel scaffold-mediated gene delivery approach that can achieve enhanced and sustained transfection of endogenous cells in vivo.

Novel In Vitro Method for Generating Human Dendritic Cells for Immunotherapy

Researchers in the UCLA Department of Pathology and Laboratory Medicine have developed a new method for generating and expanding human CLEC9A+ dendritic cells that can be used for a wide variety of immunotherapy applications.

Methods for Selecting and Identifying Cancer Stem Cells

Methods for identifying, selecting, and isolating leukemia stem cells from a biological sample or a cell culture sample using fluorescent tagged metabolites.

Engineering Human Proteases for Therapeutic Use

A methodology termed “protease evolution via cleavage of an intracellular substrate” (PrECISE) to enable engineering of human protease activity and specificity toward an arbitrary peptide target. 

Novel small molecule LOXL2 inhibitors as anti-fibrotic therapeutics

A novel small molecule anti-fibrotic agent that acts via LOXL2 inhibition

MicroRNA Fractionation

Background: The market landscape of the US global market for microRNA research tool, services, diagnostics and drug discovery is estimated to grow 13% annually and reach $1 billion in the next 4 years. The market continues to grow with many pharmaceutical and biotech companies becoming more and more involved in microRNA research to discover specific microRNA biomarkers for diagnostics and therapeutics. Current techniques are unable to identify which microRNA carriers are the most appropriate for disease diagnosis. In this regard, there are relationships between microRNA dysregulation and human disease in approximately 168 diseases, including cancers, heart disease, diabetes, alcoholism, and obesity.  Brief Description: UCR researchers have developed methods for rapid separation of different microRNA carriers in serum, using asymmetrical flow field flow fractionation or specially designed microchips. They have successfully identified microRNAs carriers as sensitive biomarkers, which will aid in the discovery of more effective therapeutic approaches. 

A Transposon Vector From Aedes Aegypti For Use In Vertebrate And Invertebrate Gene Transfer

Background: Therapeutic delivery of genes is a rapidly evolving technique used to treat or prevent a disease at the root of the problem. Another widely used variation of this technique is to insert a transgene into animals and crops for production of desirable proteins. The global transgenic market is currently $24B with annual growth projections of 10%.  Brief Description: UCR Researchers have identified a novel transposon from Aedes aegypti mosquitoes. This mobile DNA sequence can insert itself into various functional genes to either cause or reverse mutations. They have successfully developed a transposon vector system that can be used in both unicellular & multicellular organisms, which can offer notable insight to enhance current transgenic technologies as well as methods of gene therapy.

Adaptive optics with direct wavefront sensing for multi-photon microscope

Biological tissue are rarely transparent, presenting major challenges for deep tissue optical microscopy. With the advantages of high-resolution and viewing of live organisms, optical microscopy has become an important tool for biological research and continues to open new avenues in its capabilities. In recent years, image resolution and speed has been dramatically improved.  However the improvement of the resolution and penetration depth for optical microscopy is still in its infancy. As light passes through biological tissue, it can be absorbed, refracted and scattered, limiting the resolution and depth of optical imaging in biological tissues. Overcoming these challenges will benefit a wide range of applications from basic biological research to clinical investigations.

Meta-analytic Methods for Defining Prescriptive Genetic Biomarkers of Multi-gene Diseases

In most cases of complex diseases, simple genetics do not explain the etiology of disease and multi-genic analyses require patient samples and data that limit the extent to which such tools may be usefully deployed. Although primary open angle glaucoma (POAG) is clearly associated with mutations in such genes as MYOC, ASB10, WDR36, NTF4, and TBK1,  most cases of POAG do not involve these mutations at all. To better understand the genetic underpinnings of POAG, proprietary meta-analytic method have been applied to transform genetic data and the clinical features of this disease into a prescriptive set of genes for POAG.

Potential Driven Electrochemical Modification of Tissue

Researchers at UC Irvine have developed a minimally invasive technology that uses electrical potentials to perform a variety of to modify and reshape soft tissues such as cartilage

Preservation of the Neuromuscular Junction (NMJ) After Traumatic Nerve Injury.

This invention focuses on peripheral nerve injury prevention and treatment using antibodies, biomolecules, or small molecules.

Beta-Amyloid Plaque Imaging Agents

Current imaging agents for labelling β-amyloid plaques and neurofibrillary tangles (NFT), which are indicators for Alzheimer’s disease, suffer from drawbacks such as (but not limited to) non-specific binding, low target to non-target ratio, instability, and inefficient labelling. Researchers at UC Irvine have developed an imaging agent and its derivatives for labelling β-amyloid plaques and NFTs that overcome these problems and also provide therapeutic properties in vivo for the neural tissues. The labelling agent also binds to norepinephrine transporters (NET) and are taken up into the cells via the NET, therefore serving as suitable agents for diagnostic and/or therapeutic purposes involving disorders or conditions associated with NET.

Dielectrophoresis-Based Cell Destruction to Eliminate/Remove Unwanted Subpopulations of Cells

This invention allows for label free cell separations and cell enrichment.

Direct Drive Micro Hearing Device

The current state of art does not provide a satisfactory way to restore hearing without one or more of the following disadvantages; feedback, occlusion effects, easily visible, stigma, invasive surgery, expensive and/or surgery for removal. Thus, there exists a desire for a device which overcomes one or more of the aforementioned drawbacks

Design and Synthesis of Fluoroalkylpyridyl Ethers as Potential Pet Radioligands for A4B2 Nicotinic Acetylcholine / Labeled A4B2 Ligands and Methods Therefor

Researchers have developed compounds to bind to α4β2 nicotinic acetylcholine receptors to evoke antagonistic effects both in vitro and in vivo environments.

New Indication for Use of Niacin (Nicotinic Acid) for Treatment, Prevention and Reversal of Fatty Liver Disease

Non alcoholic fatty liver disease (NAFLD) is a health problem that affects approximately 30% of the population, and the up to 75% of people afflicted with obesity and type 2 diabetes. Currently, no therapeutic agent for the prevention or treatment of fatty liver disease exists. Researchers at UC Irvine have developed a strategy that suggests treatment for fatty liver disease and/or NAFLD using niacin and/or its metabolites.

Monoclonal Antibody against ATR-IP (Clone 11)

Mouse monoclonal antibody against the human ATR-interacting protein (ATR-IP). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibody Against CEP164 (Clone 13)

Mouse monoclonal antibody against the human centrosomal protein 164kDa (Cep164). This antibody binds to the phosphorylation site of Cep164 and has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Monoclonal Antibody Against CEP164 (Clone 17)

Mouse monoclonal antibody against the human centrosomal protein 164kDa (Cep164). This antibody binds to the phosphorylation site of Cep164 and has been tested for use in immunoprecipitation and western blot.

Monoclonal Antibodies Against Chk2 (Clone 4B8)

Mouse monoclonal antibody (clone 4B8) against the human Serine/threonine-protein kinase Chk2. This antibody has been tested for use in immunoprecipitation and western blot.

Monoclonal Antibodies Against Mtpap (Clone 1D3)

Mouse monoclonal antibody against the human Poly (A) RNA polymerase, mitochondrial (mtPAP). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

Histone Transferase Inhibitors to Treat and Target Drug-resistant Cancer Stem Cells

The fact that histone methyl- and acetyl-transferases modify the structure of euchromatin and gene transcription has invited the development of drugs against these enzymes. And while histone transferase inhibitors have been touted as potential cancer therapeutics, there have been challenges to realizing their potential. Recent studies suggest a more specific utility for targeting cancer stem cells and enables therapeutic options not previously available.

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