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Hyaluronic Acid-based Gel for Topical and Subcutaneous Applications

A method for producing chemically-crosslinked hydrogels using a biocompatible “click” chemistry for in situ gelation. 

Soft Tissue Gripping Device

Nerve injury in the Peripheral Nervous System is caused by trauma, vehicular accidents, repetitive stress, and wartime injuries and affects up to 1% of the U.S. population by age 70. Severed nerves lead to severe pain or the lack of sensation and mobility.

Apparatus for Growing a Heart Valve in 3D

This invention is a procedure and apparatus used to grow and shape three-dimensional heart valves tissues.

Lateral Cavity Acoustic Transducer Based Microfluidic Switch

The ability for on-chip particle/cell manipulation is important for microfluidic applications. Researchers at UC Irvine have developed a technology that exploits the phenomenon of acoustic microstreaming to manipulate fluid flow and suspended cells/particles in a microfluidic environment.

Multilayer High Density Microwells

Researchers at UC Irvine have developed high density, three dimensional (3D) micro-reactors for digital biology applications. The high-density imaging arrays overcome drawbacks associated with existing high density arrays fabricated on a single surface and the more recent 3D droplet emulsion arrays.

Direct Drive Micro Hearing Device

The current state of art does not provide a satisfactory way to restore hearing without one or more of the following disadvantages; feedback, occlusion effects, easily visible, stigma, invasive surgery, expensive and/or surgery for removal. Thus, there exists a desire for a device which overcomes one or more of the aforementioned drawbacks

New Inhibitors of the HIV Protease

Drug resistance is one of the key roadblocks towards successful treatment of AIDS. Although numerous drugs have been developed to target various viral proteins, resistant viral strains are selected in the presence of the drug to become dominant in the population, therefore severely impairing drug efficacy and increasing the cost of treatment. There is an unmet need to develop strategies to combat drug resistance.

Device for Creating Stoma with Desired Characteristics

Physicians from UCLA Department of Surgery conceptualized a device for creating clean stomata that involves a circular saw and a mechanism for stretching the skin to specific tension.

Very-Small-Nuclear Circulating Tumor Cell (vsnCTC) as a Diagnostic Biomarker of Visceral Metastasis in Advanced Prostate Cancer

UCLA researchers in the Department of Molecular and Medical Pharmacology have identified a novel biomarker that can be used to diagnose prostate cancer patients for the presence of visceral metastasis with 54% sensitivity and 100% specificity.

Improvements of cognitive function in age-related disorders and Alzheimer's disease

Cognitive deficits associated with aging and other age-related disorders involve deficits in processing sensory information, attention, consolidation of memory, recall of information, and executive functions such as planning, problem solving and self-monitoring among others. There is a large unmet medical need to identify therapies and novel therapeutic regimes for the treatment of cognitive dysfunction, e.g., cognitive deficits related to aging, age-related disorders and Alzheimer's disease. Previously published research suggests a correlation between neurological disorders and trimethylation of histone H3K9 in the brain. Therefore, an inhibitor of histone methyl transferase SUV39h1 and its effects on the progression of age-related disorders was investigated.

An integrated intraoperative diagnosis and therapy catheter system

In traditional cardiology and oncology, disease diagnosis and treatment are traditionally separate procedures resulting in increased costs and delayed treatment, which, in some cases, may increase morbidity. Therefore, a system that can diagnose and treat diseases simultaneously would greatly decrease costs and provide timely treatment, which may prevent death from the disease. Researchers in the Department of Engineering at UC Irvine, in collaboration with researchers at Shanghai Jio Tong University in China have invented a multimodal system for the diagnosis and treatment of cancer and cardiac disease. Summary of development The present invention describes an intraoperative imaging and therapy catheter system for the accurate diagnosis and treatment of cancer and cardiac disease. This multimodal medical device combines imaging, cryosurgery, and thermal therapy thereby permitting accurate diagnosis and treatment of vulnerable plaques in blood vessels and various types of cancers. In addition, by adding low cost imaging modalities such as optical coherence tomography (OCT), ultrasound imaging, photoacoustic (PA) imaging, fluorescence imaging and thermal imaging, cryosurgery can be performed with much higher accuracy. Importantly, addition of these imaging systems enables accurate identification of lesion sites, precise depth of cryosurgery/heating probe placement, and the capability to monitor the extent of the freezing/heating process. Furthermore, the invention may include intravascular ultrasound (IVUS) facilitating visualization of cross-sectional images of the vessel wall, entire large lipid pools, and large tumor regions. These parameters are valuable for the guidance of cryoplasty regarding the treatment time, temperature and location.

A Novel Use Of Action Video Game Technology in a Digital Neurotherapeutic To Improve Impaired Human Spatial, Temporal And Quantitative Cognition

A scientifically designed evidence-based digital neurotherapeutic, in the form of a video game, has been developed to challenge, engage and improve spatiotemporal processing abilities in individuals with certain neurodevelopmental disorders and the healthy aging, as well as those with some forms of acquired brain damage.

Method For Estimating The Need For Surgical Care (Or Any Other Health Care Intervention) In A Population

The need for surgical care (or any health care intervention) varies across demographics within a population because epidemiology of disease varies.  For example, demographics with higher fertility rates require more surgical procedures to address maternal health problems such as obstructed labor.  The same applies to all other diagnoses that require surgical care such as injuries, congenital anomalies and non-communicable disease.  One of the challenges of planning surgical care for a population (or any other element of health care) is to how to estimate need.  Estimating need can be used to cost interventions as well as to measure the financial impact of health care investments.  However, previous efforts to integrate surgical services into global health initiatives do not reflect the scope of surgical need and many health systems do not provide essential interventions.

A Method To Modulate The Pathologic Multireceptor Signaling Via The Giv-Gi Axis In Diverse Diseases / 2015-082

Most common diseases, e.g., cancer, inflammation, diabetes are driven by multiple cell surface receptors that trigger and sustain a pathologic signaling network. The largest fraction of therapeutic agents that target individual receptors/pathways often eventually fail due to the emergence of compensatory mechanisms. Recently, UCSD researchers identified GIV protein as a central platform for receptor cross-talk which integrates signals downstream of a myriad of upstream receptors, and modulates several key pathways within downstream signaling network, all via activation of trimeric G proteins. The researchers have conducted proof-of-concept studies demonstrating that non-genetic exogenous modulation of the GIV-Gi signaling interface using cell-penetrable synthetic GIV-derived peptides is an effective strategy to reset pathologic signaling networks downstream multiple receptors in a diverse array of pathophysiologic conditions.

Predicting Metabolic Side Effects Of Transported Drugs

Drug clearance is the important process by which a drug and/or its metabolites are eliminated from an organism.  When drug clearance is excessive, efficacy of the drug may not be achieved; when drug clearance is inadequate, toxicity to the organism may result.  Members of the solute carrier (SLC) and ATP-binding cassette (ABC) “drug” transporter families  have  well-established roles in absorbing, distributing, and eliminating xenobiotics such as drugs. In addition, there is growing evidence for suggesting that these transporters also transport metabolites, nutrients, signaling molecules, and antioxidants at the organismal and cellular levels. Competition of drugs with metabolites at the level of transporters involved in absorption, distribution, and elimination of drugs and metabolites can lead to major metabolic side effects over the long term.  Owing to the tremendous clinical importance of these transporters, there is a need to combine metabolic reconstruction (systems biology) methods with computational (pharmaceutical) chemistry, as well as wet lab validation to study these transporters of the SLC and ABC family and drug-induced metabolic changes.

Novel Optical Method To Measure Muscle Sarcomere Length

During procedures for various tendon repairs, and joint reconstructions, the detached muscle needs to be transferred and reattached to the bone. Correct adjustment of muscle length is critical to obtain maximum force from the transferred muscle.  Usually, surgeons rely on their own experience to determine the amount of tension for setting a muscle to its optimal muscle length, and it is not uncommon for the surgeon to over pull the muscle during such procedures, notably for the tendon transfer operations.  The ability to measure muscle sarcomere length in vivo provides the much-needed guide to surgeons for setting muscle at an optimal length during these procedures.  Laser diffraction, biopsy clamps, and two-photon microscopy have been used to measure in vivo sarcomere length, but each has limitations.  

An Adaptive Mobile Momentary Assessment System for Real-Time Assessment and Health Interventions

High frequency data collection in a participant’s usual environment (ecological momentary assessment, or EMA) offers a promising approach for understanding, and potentially intervening on, the precursors of clinically important states and behaviors in mental health disorders.  

An Adaptive Mobile Momentary Assessment System for Real-Time Assessment and Health Interventions

High frequency data collection in a participant’s usual environment (ecological momentary assessment, or EMA) offers a promising approach for understanding, and potentially intervening on, the precursors of clinically important states and behaviors in mental health disorders.  

Methods of Disease Modeling

Identification and evaluation of new therapeutic agents and the identification of suspected disease targets (which typically employ animal models) are expensive, time consuming, etc.  In vitro alternatives have relied on the use of conventional cell culture systems which are limited in that they do not allow the three-dimensional interactions that occur between cells and their surrounding tissue. Additionally, cells not only sense and respond to chemical cues, they also respond to the physical environments. 

Synthetic Enhancer Library

Enhancers are discrete genomic DNA segments that control tissue-specific patterns of gene expression and are essential to the development and homeostasis of multicellular organisms. Changes in gene activity have been linked to diseases such as autoimmune disorders. Despite the importance of enhancers, the relationship between primary DNA sequence and enhancer function is poorly defined. In part, this is due to the need to systematically test hundreds of thousands of enhancer mutants in whole animals in order to fully understand enhancer activity.   To address this issue, UC Berkeley researchers have developed a Synthetic Enhancer Library-Seq (SEL-Seq).  The technology couples the synthesis of enhancer variants to a barcoding method, and provides millions of unique sequences for functionally testing enhancers. 

Hearing device that amplifies sound using a tympanostomy tube

Non-invasive hearing technologies have inherent problems, including occlusion, feedback, and low satisfaction rates with sound quality and aesthetics. Middle ear implants and cochlear implants can provide acceptable sound quality, however, drawbacks of these types of devices includes high cost and the requirement for invasive surgery. To overcome these issues, researchers at UC, Irvine developed the Direct Hearing Device (DHD; previous patent). The DHD is a non-invasive hearing device that couples to the umbo at the tympanic membrane (TM; the deepest part of the eardrum) and drives the TM and attached ossicular chain to facilitate sound transmission. Researchers have continued to improve this device by exploring the best embodiment for contact between their DHD and the TM.

Method And Device For Skin Rejuvenation

A method and device for dermatology, cosmetic treatments, skin rejuvenation and scar reduction therapy

Method And Device For Dentistry

A technique to facilitate dental extraction, oral surgery, dental implant or specialized dentistry.

Methodology for Prediction of RNA and DNA Variants Using Sequencing Data

UCLA researchers in the Department of Integrative Biology and Physiology have developed a novel methodology that can determine the nature of observed single nucleotide variants in DNA and RNA sequencing data.

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