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Antimicrobial, Stimuli-responsive Polysaccharide

State of the art antimicrobial therapeutics, while effective and promising, remain only short-term solutions to the overall challenge of drug-resistant microbes. UCI researchers have developed a chitosan-based nanoantibiotic that is non-toxic and carries potential for broad spectrum use.

Biomarkers for Port Wine Stain and Related Syndromes

Researchers at the University of California, Irvine (UC Irvine) have discovered specific biomarkers that will enable innovations in diagnosis, prognosis, monitoring, and therapy of PWS and other related syndromes.

Electrode Agnostic, Supply Variant Stimulation Engine For Implantable Neural Stimulation

UCLA researchers in the Department of Electrical Engineering have invented an innovative universal agnostic electrode for implantable neural stimulation and sensing.

Load Adaptive, Reconfigurable Active Rectifier for Multiple Input Multple Output (MIMO) Implant Power Management

UCLA researchers in the Department of Electrical Engineering have invented a novel full-fledged implant power management unit, which is highly programmable and can process multiple input power deliveries on-chip.

A High Dynamic-Range Sensing Front-End For Neural Signal Recording Systems

UCLA researchers in the Department of Electrical Engineering have invented a novel neural recording chopper amplifier for neuromodulation systems that can simultaneously record and stimulate.

Epigenetic Target for HIV and Latent Virus Eradication

Researchers at the University of California, Davis, have identified a target for therapeutic intervention and agents that disrupt HIV latency in patients under suppressive HIV therapy. It amplifies the effects of other latency reversal agents and primes the cells harboring the virus for immune clearance and death.

Predictive Optimization Of Pharmeceutical Efficacy

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a machine learning platform to virtually screen combinatorial drug therapies.

Computational Sensing Using Low-Cost and Mobile Plasmonic Readers Designed by Machine Learning

UCLA researchers have developed a novel method for computational sensing using low-cost and mobile plasmonic readers designed by machine learning.

Integrated Electrowetting Nanoinjector and Aspirator

Gene therapy applications necessitate cell transfection techniques for delivering biomaterial into multiple or a single cell(s). The global market for transfection technologies can be worth more than half a billion by 2017. Current viral and chemical transfection techniques have limited ease of fabrication, transfection efficiency, dosage control, and cell viability. The invention discloses a simple yet efficient technique for nanoinjection of material into a single cell with high transfection efficiency, controlled dosage delivery, and full cell viability.

Oro-Nasogastric Tube Insertion Device

Gastric intubation is a critical part of patient care during surgical procedures, though the insertion of such tubes has up to a 50% failure rate. Researchers at UCI have developed a device that allows for accurate placement of nasal and oral gastric tubes, which in addition to being simple and inexpensive, reduces the risk of accidental tube misplacement and organ perforation.

Targeting 3-Repeat TAU for the Treatment of Neurodegenerative Tauopathy Disorders

Neurodegenerative disorders with Tau accumulation are a common cause of dementia in the aging population. Alzheimer’s Disease (AD), Pick’s Disease (PiD) and Fronto-temporal lobar degeneration (FTLD) are examples of neurodegenerative disorders with Tau accumulation and are also jointly referred as “taupathies”. Tauopathies are a group of neurodegenerative disorders with accumulation of three-repeat (3R) or four-repeat (4R) Tau. While 3R tau is found in Pick's disease and Alzheimer's disease (AD), 4R tau is more abundant in corticobasal degeneration, progressive supranuclear palsy, and AD.

Preganancy Hormone-Containing Combination Products for the Continuous Treatment of Autoimmune Diseases

UCLA researchers in the Departments of Neurology have discovered that the combination of certain pregnancy hormones can treat autoimmune disorders like multiple sclerosis.

Hand Held Aerosol (HFA) Detector

The inventors have developed various devices, including in one embodiment, an inexpensive hand held device that can measure a wide range of HFA-134a levels in human breath. The present invention is also directed to a kit for detection of one or more halogenated organic compounds. The kit is useful for practicing the inventive method of measuring asthma inhaler compliance, for example.

Drift-Free and Calibration-Free Measurement of Analytes

A method of achieving the calibration- and drift-free operation of voltammetric electrochemical biosensors.

Small Molecule Treatment for Androgen Inhibitor-Resistant Cancers

Researchers at the University of California, Davis have developed small molecule inhibitors of androgen receptor variants for the treatment of androgen inhibitor-resistant cancers.

Endoscopic, Laparoscopic, Robotic And Minimally Invasive Force Sensor And Monitoring System

Minimally invasive ureteroscopy is a common procedure in adults, with over 10,000 procedures conducted annually in California alone. The ureteral access sheath (“UAS”), a highly effective device used to facilitate minimally invasive ureteroscopy, can injure the patient when excessive force is used during its placement. Inventors at UCI have developed a minimally invasive force sensor and monitoring system that measures force during UAS placement and can preclude injury by alerting the physician when the threshold for injury is being approached. It thus can be used for medical personnel safety training, quality control and standardization of minimally invasive ureteroscopy, as well as being applied to the passage of other catheters into natural orifices or channels./

Hair Follicle Stem Cell Activation & Hair Growth by Metabolic Regulators

The Lowry group at UCLA has discovered that topical application of a small molecule accelerates hair growth and combats hair loss by promoting glycolytic metabolism in hair follicle stem cells.

Novel Anti-Bacterial, Anti-Fungal Nanopillared Surface

Medical devices are susceptible to contamination by harmful microbes, such as bacteria and fungi, which form biofilms on device surfaces. These biofilms are often resistant to antibiotics and other current treatments, resulting in over 2 million people per year suffering from diseases related to these contaminating microbes. Death rates for many of these diseases are high, often exceeding 50%. Researchers at UCI have developed a novel anti-bacterial and anti-fungal biocomposite that incorporates a nanopillared surface structure that can be applied as a coating to medical devices.

Nanoporous Metal Foam Filters for Clean Air

Researchers at the University of California, Davis have developed nanoporous metal foams as universal pollutant arrestors.

Novel Inhibitors of Mitochondrial Electron Transport

Researchers at the University of California, Davis have discovered a class of compounds that both bind to a unique newly-discovered binding site in respiratory complex III and act as inhibitors of electron transport for use as mitochondrial anti-cancer drugs.

Automated Optical Chest Tube Air Leak Detection System

UCLA researchers in the Department of Surgery have developed an air leak detection system for use in patients requiring chest tube placement.

Monitor Alarm Fatigue Allevation By SuperAlarms - Predictive Combination Of Alarms

UCLA researchers in the Department of Neurosurgery have developed a method that is capable of mining a collection of monitor alarms to search for specific combinations of encoded monitor alarms to predict certain adverse event, such as in-hospital code blue arrests or other target events.

Biologically Applicable Water-Soluble Heterogeneous Catalysts For Parahydrogen-Induced Polarization

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method of parahydrogen-induced polarization in water using heterogeneous catalysts.

Cloud-Based Pulmonary Spirometry System

Inventors at UC Irvine developed a portable spirometry system that automatically uploads patient pulmonary data to the Internet, and provides a cloud-based platform to analyze and share the data with an attending healthcare professional.

Scanning Method For Uniform, Normal-Incidence Imaging Of Spherical Surface With A Single Beam

UCLA researchers have created a method that achieves uniform normal-incident illumination of a spherical surface by first projecting the sphere onto a Cartesian plane and then raster scanning it using an illuminating beam. This allows the scanned object, the illumination source, and the detector to remain stationary.

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