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Stimulus-responsive Polymers

Synthetic polymer constructs are an important tool in modern medical practice, but the lack of control over their activity limits their utility. The ability to combine structural function with localized interaction has proven extremely successful in stents, but polymer technology has not advanced sufficiently to serve a wider range of needs. PLGA polyesters can be degraded by hydrolysis facilitating their widespread use in medicine and biomedical research. Their dependence on slow hydrolysis makes for long degradation times (half-life of one year in vivo) limiting their applicability. While degradation can be sped up by copolymerization with more hydrophilic monomers; degradation is still too slow for triggered release or degradation.

Artery-on-a-Chip for Capturing Inflammatory Monocytes to Assess Cardiovascular Health

Researchers at the University of California, Davis have developed a microfluidic device that measures cardiovascular disease risk by quantifying the frequency of adherent monocytes in blood and assessing the activation level of circulating inflammatory cells.

Novel Auditory Diagnostic

Researchers at the University of California, Davis, have developed a novel diagnostic for the auditory system.

STRUCTURAL AND MECHANICAL CHANGES TO JOINT CAPSULES, TENDONS AND LIGAMENTS

Technology is designed to treat diseases of the joints (joint capsules specifically), tendon and ligament disorders.

Molecular Photoswitches as MRI Contrast Agents Sensitive to Light/Bioluminescence

Researchers at the University of California, Davis have developed a light-activated gadolinium contrast agent.

Novel Hydrogel for Optimized Cell Delivery, Culture and Inflammation Prevention from De-cellularized Human Amniotic Membrane

A novel, human amnion derived hydrogel has been shown to considerably optimize cell delivery and scaffolding by increasing cellular survival, proliferation, and integration, as well as significantly decreasing host rejection and morbidity.

Microfabricated Silicon-Based Hollow Microneedles with Integrated Fluid Channels for Transdermal Fluid

Research conducted at the University of California, Davis has led to an improved method and apparatus for puncturing a surface for extraction, in situ monitoring, and substance delivery.

Nanoporphyrin Nanoparticles for Combination Phototherapy and Drug Delivery to Infantile Hemangiomas

Researchers at the University of California Davis have developed a novel treatment method that combines photodynamic therapy and the therapeutic compound propranolol using a nanoparticle platform to treat infantile hemangiomas (IH).

Directed Facial Nerve Stimulation

An implantable medical device for stimulating the damaged facial nerve of a patient with permanent facial paralysis. The technology affords control of nerve fibers that contribute to facial movements, such as blinking and smiling, and facial expression of emotion.

A High-Throughput Screen For Drug And Disease Investigations In A Simple Neuronal Culture

Drug discovery and development consists of an arduous testing process, and cell-based screening methods represent a crucial source of information in the decision making process to evaluate mode of action, efficacy and toxicity for new therapeutics in early phases if preclinical drug development. Despite advances in cell-based screening assays, a need remains for newer and better assays to identify and validate drug s for treatment and/or prevention of neuronal diseases. Such newer assays should have a higher speed, lower cost, high sensitivity and high signal to noise ratio. Further, there needs to be improved methods for assessing toxicity of drug candidates.

Delivery Module for Delivering Biotherapeutics Throughout the Body

Researchers at the University of California, Davis have developed a robust and broadly applicable system for the delivery of peptide and oligonucleotide biotherapeutics.

UCLA Inventors Create Platform Technology to Create Customizable Nanoscale Wound Management Tools

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale vesicles and hydrogels for use in wound management. The poly-peptide based platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, be loaded with hydrophobic, hydrophilic, or cellular payloads, adaptable to specific delivery locations, low toxicity, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis. The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can be used to augment existing material systems.

A Self-Regenerative Hybrid Tissue Structure For 3D fabrication of heart valves, blood vessels and other constructs / Mesh enclosed tissue constructs

Current tissue engineered constructs face drawbacks such as structural vulnerability, functionality, and a lack of mechanical properties. A continual need for a tissue constructs that can resist the physiological forces within the body, while being biocompatible, persists. Researchers at UC Irvine have developed a tissue construct composed of a multi-layered tissue enclosed on a metal mesh that addresses the drawbacks experienced by other developed solutions.

Cardiomyocyte Maturation Platform

The invention is a methods platform used to mature cardiomyocytes (“CMs”). The invention utilizes a cardiac microenvironment to induce and promote maturation of cardiomyocytes. The invention exposes cardiomyocytes in vitro to conditions similar to their natural environment, such as to a three-dimensional scaffold of cardiac extracellular matrix (ECM) and other cell types including endothelial cells and stromal cells. These interactions between the cells, ECM, and environment are known to promote cardiomyocyte maturation in vivo. Through the invention, the CMs will mature in vitro at a rapid rate faster than they would normally mature in vivo.

Topical Drugs To Reduce Excessive Hair Growth

Excessive hair disorders (hypertrichosis, hirsutism) can have severe impact on an individual's self-esteem and ability to interact successfully in the workplace and social settings.  Existing therapies, with a potential for long-term hair removal, include laser therapy and/or electrolysis.  These require multiple courses, are expensive and may not be fully or permanently effective.  While hirsutism may respond to medical/hormonal therapies, such as oral contraceptive pills (OCPs), glucocorticoids, or antiandrogens such as spironolactone, these often have adverse side effects such as fatigue, pain, weight gain, depression.  Furthermore, many patients find that they still require laser or electrolysis in addition to medical therapy.  Therefore there is a large unmet need for safe, simple and cost-effective treatments for hypertrichosis.

Pediatric Resuscitation and Ventilation Monitor

Researchers at the University of California, Davis have developed a pediatric resuscitation monitor that allows for proper ventilation rate and tidal volume based on a patient’s age and height. This system will help first responders and emergency physicians provide optimal ventilation to pediatric patients during emergency resuscitation.

Hyaluronic Acid-based Gel for Topical and Subcutaneous Applications

A method for producing chemically-crosslinked hydrogels using a biocompatible “click” chemistry for in situ gelation. 

Soft Tissue Gripping Device

Nerve injury in the Peripheral Nervous System is caused by trauma, vehicular accidents, repetitive stress, and wartime injuries and affects up to 1% of the U.S. population by age 70. Severed nerves lead to severe pain or the lack of sensation and mobility.

Apparatus for Growing a Heart Valve in 3D

This invention is a procedure and apparatus used to grow and shape three-dimensional heart valves tissues.

Lateral Cavity Acoustic Transducer Based Microfluidic Switch

The ability for on-chip particle/cell manipulation is important for microfluidic applications. Researchers at UC Irvine have developed a technology that exploits the phenomenon of acoustic microstreaming to manipulate fluid flow and suspended cells/particles in a microfluidic environment.

Multilayer High Density Microwells

Researchers at UC Irvine have developed high density, three dimensional (3D) micro-reactors for digital biology applications. The high-density imaging arrays overcome drawbacks associated with existing high density arrays fabricated on a single surface and the more recent 3D droplet emulsion arrays.

Direct Drive Micro Hearing Device

The current state of art does not provide a satisfactory way to restore hearing without one or more of the following disadvantages; feedback, occlusion effects, easily visible, stigma, invasive surgery, expensive and/or surgery for removal. Thus, there exists a desire for a device which overcomes one or more of the aforementioned drawbacks

New Inhibitors of the HIV Protease

Drug resistance is one of the key roadblocks towards successful treatment of AIDS. Although numerous drugs have been developed to target various viral proteins, resistant viral strains are selected in the presence of the drug to become dominant in the population, therefore severely impairing drug efficacy and increasing the cost of treatment. There is an unmet need to develop strategies to combat drug resistance.

Device for Creating Stoma with Desired Characteristics

Physicians from UCLA Department of Surgery conceptualized a device for creating clean stomata that involves a circular saw and a mechanism for stretching the skin to specific tension.

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