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Methods And Devices for Continuous Analyte Sensing with Microporous Annealed Particle Gels

UCLA researchers in the Department of Bioengineering have developed novel microporous annealed particle gels for long-term continuous monitoring of blood metabolites.

Fully Human Antibody Fragments Against Human N-Cadherin

UCLA researchers at the Department of Molecular & Medical Pharmacology have developed fully human antibody fragments against human N-cadherin that can potentially be used to evaluate EMT (epithelial-mesenchymal transition) status for diagnostic and prognostic purposes.

Airway Manikin With Realistic Mobility

Training for direct laryngoscopy relies heavily on practice with patients. The necessity for human practice might be supplanted to some extent by an intubation manikin with accurate airway anatomy, a realistic “feel” during laryngoscopy, the capacity to model many patient configurations, and a means to provide feedback to trainees and instructors. The realism and mobility of the anatomical features of current models limits the effectiveness of training intubation skills. Current models provide only one set of anatomic features, but patients present innumerable combinations of size, shape, proportion, and tissue stiffness. Thus, a novice who trains on a particular model merely learns how to intubate that particular model, but has minimal ability to transfer the learned skills to the multiplicity of anatomies in patients. Furthermore, most models approximate a normal anatomic configuration that poses no problem for intubation, so novices do not gain experience with difficult situations

System And Method For Automated Image Guided Robotic Intraocular Surgery

UCLA researchers in the Departments of Mechanical Engineering and Ophthalmology have developed a system and method for automated optical surgery.

Physical Multi-Layer Arm Phantom For Body Area Networks

Researchers at UCI have developed an oil-based in vitro phantom that accurately mimics the electrical properties of the human arm. Due to the increased accuracy it affords, this phantom can be used to test the efficiencies of wireless medical devices in body area networks.

A Delivery System for Percutaneous Delivery and Implantation Of Atrioventricular Heart Valves

The invention is a novel delivery system providing a minimally invasive solution for the delivery and implantation of atrioventricular heart valves. Through its novel mechanical structure, the invention delivers and positions the valve accurately with no need for painful surgeries or bulky tools.

Approach For Efficient Protein Incorporation Into Recombinant Vaults

UCLA researchers in the departments of Medicine, Microbiology, Immunology & Molecular Genetics, and Bioengineering have developed a novel method for loading protein payloads into vault nanoparticle carriers.

Multi-Echo Spin-, Asymmetric Spin-, And Gradient Echo Echoplanar Imaging (Message-EPI) MRI

UCLA researchers in the Department of Radiological Sciences have developed a new MRI pulse sequence optimized for brain imaging.

A Transparent, Self-Healing, Highly Stretchable Ionic Conductor

Researchers at the University of California, Riverside have developed a transparent, highly stretchable, self-healing, ionic conductor.  The conductor is comprised of a polar polymer and an ionic salt solution. The material is held together via charge interactions between these two components, which prevents leakage of the ionic solution out of the material. This material can tolerate strains above 5000% and maintains an optical transmittance of 92%. Additionally, the material is spontaneously reversible (goes back to its original shape) for strains under 50%.  When a sample of this material is cut into two pieces and connected together, the sample spontaneously self-healed under ambient conditions within 24 hours.   Fig. 1 Photos of a healed material sample in the non-deformed state and stretched to five times its original length.   Fig. 2 Optical microscope images of a cut material sample after different healing times at room temperature. The damaged sample fully healed after 24 hours. Scale bar is shown at 500 μm.   Fig. 3 Healing efficiency (recovered fracture toughness) at different ambient temperatures

Selective Voltage Gated KV1.3 Potassium Channel Inhibitors

Researchers at the University of California, Davis, have discovered a composition of 5-phenoxyalkoxypsoralens that inhibits potassium channels to treat autoimmune diseases and disorders that involve abnormal homeostasis, body weight and peripheral insulin sensitivity.

Antisense Oligonucleotide Therapy for B Cell Mediated Cancers

Researchers at the University of California, Davis have developed a targeted therapy using an antisense oligonucleotide (ASO) to treat precursor B cell (pre-B) acute lymphoblastic leukemia (ALL).

Lensfree Tomographic Imaging

UCLA researchers in the Department of Electrical Engineering have developed a system for lens-free tomographic imaging.

Inhibition of Pyruvate Oxidation to Promote Hair Growth

UCLA researchers in the departments of Molecular, Cell & Developmental Biology and Biological Chemistry have elucidated a novel mechanism by which pyruvate oxidation can be inhibited in order to promote hair growth.

Algorithm for Diabetes Management and Control

A number of technologies have been developed that optimize the process of managing blood sugar and administering insulin.  

Capture device for small urinary tract stones

The invention is a surgical device designed to remove miniature fragments of uroliths that are less than 2 mm in size. Through the invention’s novel design, such small fragments are captured in the device which will then be easily removed by the surgeon. Removing small stone fragments will reduce the need for future medical procedures.

Obstruction Prevention Airway Collar

Though deep sedation is a routine part of many medical procedures, patients under anesthesia are susceptible to airway obstruction as their throat and tongue muscles relax. Most common methods to prevent obstruction are complicated and carry additional risks. Researchers at UCI have developed a safe and comfortable medical collar that maintains patients’ airways and is entirely adjustable.

Sonification-Facilitated Cognitive Training System to Enhance Visual Learning and Memory

UCLA researchers in the Department of Psychology have developed a new cognitive training tool to enhance visual learning and memory using sound.

Near-Realistic Sports Motion Analysis and Activity Monitoring

UCLA researchers in the Department of Computer Science have developed a new technology to fight the growing obesity epidemic by encouraging exercise in video games.

Colorimetric Sensing Of Amines

An affordable and easily synthesized indicator that can be applied to monitor reaction progress in a system using only one inexpensive and non-toxic agent.

Automated Beam Orientation and Scanning Spot Spacing Optimization for Robust Heavy Ion Radiotherapy Therapy

UCLA researchers in the Department of Radiation Oncology have developed a new method to automate and optimize heavy ion beam radiotherapeutic techniques for the treatment of cancer.

Diagnosis and Treatment of Arteriovenous Malformations

UCLA researchers in the Departments of Molecular, Cell, and Development Biology & Surgery have identified Angiopoietin 2 (Ang-2) as a marker and potentially a strong contributing factor to the clinical presentation of pulmonary arteriovenous malformations.

Novel Targets And Use Of Small Molecule BT-2 To Treat Heart Failure, Obesity And Diabetes

UCLA researchers from the Cardiovascular Theme in the Departments of Anesthesiology, Physiology and Medicine have discovered new pathways and potential treatment options for heart failure, obesity, and diabetes

Compositions Of Polyion Complex Polypeptide Hydrogels

UCLA researchers in the Department of Bioengineering have developed a new class of cell-compatible copolypeptide hydrogels that possess chain conformation directed polyion complex (PIC) supramolecular architectures.

An MR-Compatible System for Motion Emulation

Researchers at UCLA from the Departments of Mechanical Engineering and Radiological Sciences have developed a magnetic resonance (MR) compatible device that can emulate respiratory motion.

Laser-Assisted Intraocular Surgical Alignment

UCLA researchers in the department of Mechanical Engineering have developed an automated procedure for aligning a remote center of motion to a surgical incision point for robot-assisted surgeries.

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