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Building blocks for 3D, modular microfluidics

Researchers at the University of CA, Irvine have developed modular microfluidic platforms consisting of microfluidic building blocks that can be connected in various configurations to construct complete microfluidic devices for different applications.

AN IMPROVED MEANS OF CEMENTING DENTAL CROWNS ONTO IMPLANT ABUTMENTS

Today, the majority of dental implant restorations are cement retained and faulty techniques are still problematic. During the cementation process, the crown is filled with cement and placed over the abutment. Apical forces are applied to the crown as it is "pushed" into place. Excess cement may extrude from beneath the crown and set onto subgingival surfaces of the implant. Since the junctional epithelium is much more fragile than that of a natural tooth, this process may allow excess cement to travel even further down the implant thread pattern. Incomplete removal of cement from the sulcular peri-implant tissues leaves a nidus of inflammation that causes bone loss and loss of osseointegration. It is almost impossible to remove 100% of this residual cement leaving a roughened implant surface. The body's inflammatory response is activated and loss of osseointegration and/or peri-implantitis may result. Improved materials and techniques to affix a crown to an abutment, without residual cement threatening future implant failure, is needed. Researchers at UCI have developed a technique that has the advantage of using a very small amount of adhesive to mate the 2 surfaces, avoiding cement extrusion and ultimately avoiding implant failures due to restorative techniques.

An Integrated Microfluidic Platform For Selective Extraction Of Single-Cell mRNA

The invention is a high-density, single-cell trapping array. A specialized probe tip can be precisely manipulated to non-destructively collect targeted intracellular material from the trapped cells for measurements. Due to the non-destructive nature of the invention, the integrity and function of the trapped cells can be preserved and they can be monitored over time to better understand disease processes.

Dual-Labeled E-AB Platform for Continuous, Real-Time Monitoring of Small Molecules

A dual-reporter correction to enhance the performance of electrochemical aptamer-based sensors in whole blood.

Capsule Holder For Safe and Efficient Liquid Medication Extraction in Pharmacy Setting

Extraction of liquid medication from a prefabricated pill capsule is necessary in instances when physical swallowing is not possible. Herein is presented a novel device that allows a pharmacy technician to stabilize a capsule and safely remove and isolate the contained liquid medication.  This method safely provides a drug that can be administered by means that do not require swallowing, such as via feeding tube.

Non-Invasive Thermal Calorimetric Method For Estimating Blood Flow In Extremities Especially The Diabetic Foot

Background: The CDC estimated that diabetes costed the US $245B in 2012, with 1.7M new diagnoses every year. As the prevalence continues to grow, a better means to monitor diabetes and prevent furthering the condition is needed. Among many complications, foot ulcers are the most common and is a result of constricted blood flow to the lower extremities. There is great traffic in the market for preventing diabetic foot ulcers with growth projections of $1.6B by 2017.   Brief Description: UCR researchers have developed a novel, non-invasive method for monitoring blood flow in the lower extremities. They incorporated thermal monitors plus a computer chip into a boot-like device. Now a diabetic patient can simply insert their foot into the device to measure blood flow rate. The current method to obtain blood flow information is with Doppler ultrasound, which is costly and requires a skilled technician in a hospital setting. The boot device can serve potentially as an at-home diagnostic monitor that will help patients become more actively aware of their condition, and with physician’s guidance prevent the diabetic foot from advancing to more serious complications.

Regulating the Microbiome with Disease-Associated Genes

Background: Inflammatory Bowel Disease (IBD) is a chronic condition with substantial health and economic costs, affecting 1.3M people in the US. Currently, there is a lack of precise understanding of IBD and therefore, many are misdiagnosed or not even diagnosed at all. There is a high demand for effective and preventative therapies to reduce the burdens of IBD. Most of the time, patients have to resort to surgery which is a very expensive and invasive process. The IBD market is expected to be $9.6B in 2017 and is projected to show robust growth due to increasing IBD prevalence.   Brief Description: UCR researchers have discovered a novel gene that can be modulated to control the microbiome. It is also the first evidence of identifying a specific bacteria in a mouse model of human disease. This discovery will allow for insight into how and which human disease-associated genes are involved in modifying the microbiome to offer better therapeutic solutions in alleviating the disease.

Piezo Scaler With Laser Capabilities

A power driven dental device that utilizes light & sound to remove deposits from the teeth, reduce bacterial loads, and promote soft tissue healing while preventing disease transfer both inside and outside the oral cavity.

Synthesis of Lipobactins and Teixobactin Analogues – New Antimicrobial Compositions against Gram-Positive Bacteria

With the discovery of penicillin in the 1940’s, many scientists proclaimed the defeat of infectious diseases which had plagued mankind. However, the remarkable healing power of antibiotics unfortunately invited widespread and indiscriminate use of antibiotics. This misuse and overuse of antibiotics has led to the dramatic rise in antibiotic resistant bacterial strains and increased healthcare costs.

Injectable Magnetic Nanocomposite Implants For Tissue Repair

Background: In 2014, the orthopedic soft tissue repair market was $10.3B, and is expected to grow due to an increasing number of soft tissue injuries with very few alternatives to surgery. Current procedures are very invasive, and require drilling holes followed by bone marrow extraction to repair the damaged tissue. Not only is the procedure costly, but the patient is held in recovery for a very long period of time.  Brief Description: UCR researchers have developed 3D magnetic nanocomposite scaffolds that can be injected into the target site for improved tissue regeneration and healing. The material can fill any shape or size of the defective site in just 2 injections. The first injection targets subchondral bone followed by a second injection that promotes cartilage regeneration. This novel invention will allow the patient to save costs incurred on surgical procedures, and regain full functionality under a shorter recovery time.

Methods for Disrupting HIV Latency Using Anti-HIV Latency Agents

Researchers at the University of California, Davis have developed methods for reactivating latent viral infection in peripheral blood samples of human immunodeficiency virus (HIV)-infected individuals receiving anti-retroviral therapy and for optimizing the process by including additional reactivation agents.

Sheet of Disposable Drug Formulation Pouches

University of California, Berkeley has an ornamental design for a sheet of disposable drug formulation pouches.

Protein-Graphene Hybrid Supercapacitor

A protein-graphene hybrid supercapacitor that offers greater capacitance, programmability, and consistency at lower cost than current supercapacitors.

Stimulus-responsive Polymers

Synthetic polymer constructs are an important tool in modern medical practice, but the lack of control over their activity limits their utility. The ability to combine structural function with localized interaction has proven extremely successful in stents, but polymer technology has not advanced sufficiently to serve a wider range of needs. PLGA polyesters can be degraded by hydrolysis facilitating their widespread use in medicine and biomedical research. Their dependence on slow hydrolysis makes for long degradation times (half-life of one year in vivo) limiting their applicability. While degradation can be sped up by copolymerization with more hydrophilic monomers; degradation is still too slow for triggered release or degradation.

Artery-on-a-Chip for Capturing Inflammatory Monocytes to Assess Cardiovascular Health

Researchers at the University of California, Davis have developed a microfluidic device that measures cardiovascular disease risk by quantifying the frequency of adherent monocytes in blood and assessing the activation level of circulating inflammatory cells.

Novel Auditory Diagnostic

Researchers at the University of California, Davis, have developed a novel diagnostic for the auditory system.

STRUCTURAL AND MECHANICAL CHANGES TO JOINT CAPSULES, TENDONS AND LIGAMENTS

Technology is designed to treat diseases of the joints (joint capsules specifically), tendon and ligament disorders.

Preparation of Furan Fatty Acids from 5-(Chloromethyl) Furfural

Researchers at the University of California, Davis have developed a novel, efficient route to a new class of dietary supplements with antioxidant, anti-inflammatory, and possible cardioprotective properties.

Molecular Photoswitches as MRI Contrast Agents Sensitive to Light/Bioluminescence

Researchers at the University of California, Davis have developed a light-activated gadolinium contrast agent.

Novel Hydrogel for Optimized Cell Delivery, Culture and Inflammation Prevention from De-cellularized Human Amniotic Membrane

A novel, human amnion derived hydrogel has been shown to considerably optimize cell delivery and scaffolding by increasing cellular survival, proliferation, and integration, as well as significantly decreasing host rejection and morbidity.

Microfabricated Silicon-Based Hollow Microneedles with Integrated Fluid Channels for Transdermal Fluid

Research conducted at the University of California, Davis has led to an improved method and apparatus for puncturing a surface for extraction, in situ monitoring, and substance delivery.

Nanoporphyrin Nanoparticles for Combination Phototherapy and Drug Delivery to Infantile Hemangiomas

Researchers at the University of California Davis have developed a novel treatment method that combines photodynamic therapy and the therapeutic compound propranolol using a nanoparticle platform to treat infantile hemangiomas (IH).

Directed Facial Nerve Stimulation

An implantable medical device for stimulating the damaged facial nerve of a patient with permanent facial paralysis. The technology affords control of nerve fibers that contribute to facial movements, such as blinking and smiling, and facial expression of emotion.

Delivery Module for Delivering Biotherapeutics Throughout the Body

Researchers at the University of California, Davis have developed a robust and broadly applicable system for the delivery of peptide and oligonucleotide biotherapeutics.

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