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Molecular Algorithm for Intragraft Assessment of Cardiac Allograft Rejection

UCLA researchers in the Department of Medicine have developed a methodology that improves the classification of endomyocardial biopsy-based data gathered from gene expression profiles and clinical phenotypes.

Electronically controllable laser and point location system for body worn laser therapeutic systems

Photonic physiological and neurological stimulation is the application of therapeutic lasers to classical acupuncture points on the body for therapeutic purposes. The therapy is typically delivered with a manually held and adjusted laser, which can be inexact and unsteady. Working together, inventors at UCI and Samueli Institute have developed a computer-controlled photonic stimulation system that is capable of using complex therapy protocols to provide more effective treatment using multiple laser sources.

Devices and systems using signal processing algorithms to improve speech intelligibility and listening comfort

The present invention relates generally to the fields of bioengineering and medicine and more particularly to methods, devices and systems that use signal processing algorithms to improve hearing in hearing impaired subjects. Methods, devices and systems for improving hearing and for treating hearing disorders, such as auditory neuropathies. A hearing enhancement system of this invention generally comprises; an amplitude modulation processor, a frequency high-pass processor, a frequency upward-shifting processor and a formant upward-shifting processor.


The present invention relates generally to speech processing strategies, and more particularly to adapting speech coders to improve the performance of cochlear implants. Cochlear implant performance is improved by extracting pitch information and encoding such pitch information into the processor of a cochlear implant. One embodiment of the invention is to explicitly extract the pitch and deliver it to the cochlear implant by co-varying the stimulated site and rate. Another embodiment of the invention is to implicitly encode the pitch information via a code book that serves as the carrier of stimulation in the cochlear implant.

microfluidic device for preparation of monodisperse microcapsules and microvesicles

Many applications, ranging from in vivo cell culture growth to drug delivery, rely on microcapsules to encapsulate and protect cells or molecules until their desired release. These microcapsules are typically generated in immiscible fluid, which must be depleted before they can be effectively used. Researchers at UCI have recently developed a paper-based microcapsule extraction technique that is quicker, cheaper, and less damaging than conventional methods.


Sucralose has become widely used as an artificial sweetener due in large part that it has low caloric content and is 600 times sweeter than table sugar (sucrose). Due to its resistance to metabolic degradation, sucralose can also be used as a marker for noninvasively assessing gastrointestinal small intestine or colonic permeability. This urinary marker is traditionally analyzed by time consuming and expensive methods, such as high performance liquid chromatography coupled to mass spectrometry or evaporative light scatter as the detectors. We have developed an alternative methodology of using a chemical-fluorescent technique for rapid analysis of halogenated disaccharides, such as sucralose.

Immunolobulin G thermal protectants

UCI scientists developed a synthetic affinity agent that functions as a thermal protectant for IgG.

Highly Stretchable Electronic Tactile Sensors

A stretchable electronic tactile sensor that can be stretched over 50% in at least two axial directions.

Building blocks for 3D, modular microfluidics

Researchers at the University of CA, Irvine have developed modular microfluidic platforms consisting of microfluidic building blocks that can be connected in various configurations to construct complete microfluidic devices for different applications.


Today, the majority of dental implant restorations are cement retained and faulty techniques are still problematic. During the cementation process, the crown is filled with cement and placed over the abutment. Apical forces are applied to the crown as it is "pushed" into place. Excess cement may extrude from beneath the crown and set onto subgingival surfaces of the implant. Since the junctional epithelium is much more fragile than that of a natural tooth, this process may allow excess cement to travel even further down the implant thread pattern. Incomplete removal of cement from the sulcular peri-implant tissues leaves a nidus of inflammation that causes bone loss and loss of osseointegration. It is almost impossible to remove 100% of this residual cement leaving a roughened implant surface. The body's inflammatory response is activated and loss of osseointegration and/or peri-implantitis may result. Improved materials and techniques to affix a crown to an abutment, without residual cement threatening future implant failure, is needed. Researchers at UCI have developed a technique that has the advantage of using a very small amount of adhesive to mate the 2 surfaces, avoiding cement extrusion and ultimately avoiding implant failures due to restorative techniques.

An Integrated Microfluidic Platform For Selective Extraction Of Single-Cell mRNA

The invention is a high-density, single-cell trapping array. A specialized probe tip can be precisely manipulated to non-destructively collect targeted intracellular material from the trapped cells for measurements. Due to the non-destructive nature of the invention, the integrity and function of the trapped cells can be preserved and they can be monitored over time to better understand disease processes.

Dual-Labeled E-AB Platform for Continuous, Real-Time Monitoring of Small Molecules

A dual-reporter correction to enhance the performance of electrochemical aptamer-based sensors in whole blood.

Capsule Holder For Safe and Efficient Liquid Medication Extraction in Pharmacy Setting

Extraction of liquid medication from a prefabricated pill capsule is necessary in instances when physical swallowing is not possible. Herein is presented a novel device that allows a pharmacy technician to stabilize a capsule and safely remove and isolate the contained liquid medication.  This method safely provides a drug that can be administered by means that do not require swallowing, such as via feeding tube.

Piezo Scaler With Laser Capabilities

A power driven dental device that utilizes light & sound to remove deposits from the teeth, reduce bacterial loads, and promote soft tissue healing while preventing disease transfer both inside and outside the oral cavity.

Engineered-Microparticle-Based Cell Carriers For Culture And Adhesive Flow Cytometry

The Di Carlo group at UCLA has invented a microparticle that enables the analysis of adherent cells by flow cytometry. In addition, they have developed a high-throughput method to fabricate these microparticles.

Synthesis of Lipobactins and Teixobactin Analogues – New Antimicrobial Compositions against Gram-Positive Bacteria

With the discovery of penicillin in the 1940’s, many scientists proclaimed the defeat of infectious diseases which had plagued mankind. However, the remarkable healing power of antibiotics unfortunately invited widespread and indiscriminate use of antibiotics. This misuse and overuse of antibiotics has led to the dramatic rise in antibiotic resistant bacterial strains and increased healthcare costs.

Injectable Magnetic Nanocomposite Implants For Tissue Repair

Background: In 2014, the orthopedic soft tissue repair market was $10.3B, and is expected to grow due to an increasing number of soft tissue injuries with very few alternatives to surgery. Current procedures are very invasive, and require drilling holes followed by bone marrow extraction to repair the damaged tissue. Not only is the procedure costly, but the patient is held in recovery for a very long period of time.  Brief Description: UCR researchers have developed 3D magnetic nanocomposite scaffolds that can be injected into the target site for improved tissue regeneration and healing. The material can fill any shape or size of the defective site in just 2 injections. The first injection targets subchondral bone followed by a second injection that promotes cartilage regeneration. This novel invention will allow the patient to save costs incurred on surgical procedures, and regain full functionality under a shorter recovery time.

Chemical Cocktail For Deriving Myogenic Cells

In postnatal life, growth and repair of skeletal muscle fibers are mediated by the satellite cells. These cells divide at a slow rate to sustain both self-renewal and growth of skeletal muscle tissue. In response to muscle injury, satellite cells divide and fuse to repair or replace the damaged muscular fibers. However, the self-renewal potential of adult satellite cells is limited and is compromised with aging, excessive trauma, or genetic defect as in certain severe muscular dystrophies such as Duchenne muscular dystrophy. In such cases, external interventions are needed.             UC Berkeley researchers have developed a chemical cocktail that allows large number of myogenic stem cells to be derived from, but no limited to, mouse dermal fibroblasts. These myogenic stem cells could then be transplanted into diseased or injured skeletal muscle to promote regeneration and recovery. In addition, the chemicals could be directly delivered into diseased or injured skeletal muscle to promote regeneration in vivo.  The mixture allows large number of patient-specific skeletal muscle cells to be obtained conveniently from non-invasive skin biopsy techniques. The in vitro culture of these skeletal muscle cells can then be used for disease modeling and drug screening purposes.

Methods for Disrupting HIV Latency Using Anti-HIV Latency Agents

Researchers at the University of California, Davis have developed methods for reactivating latent viral infection in peripheral blood samples of human immunodeficiency virus (HIV)-infected individuals receiving anti-retroviral therapy and for optimizing the process by including additional reactivation agents.

Sheet of Disposable Drug Formulation Pouches

University of California, Berkeley has an ornamental design for a sheet of disposable drug formulation pouches.

Protein-Graphene Hybrid Supercapacitor

A protein-graphene hybrid supercapacitor that offers greater capacitance, programmability, and consistency at lower cost than current supercapacitors.

Stimulus-responsive Polymers

Synthetic polymer constructs are an important tool in modern medical practice, but the lack of control over their activity limits their utility. The ability to combine structural function with localized interaction has proven extremely successful in stents, but polymer technology has not advanced sufficiently to serve a wider range of needs. PLGA polyesters can be degraded by hydrolysis facilitating their widespread use in medicine and biomedical research. Their dependence on slow hydrolysis makes for long degradation times (half-life of one year in vivo) limiting their applicability. While degradation can be sped up by copolymerization with more hydrophilic monomers; degradation is still too slow for triggered release or degradation.

Artery-on-a-Chip for Capturing Inflammatory Monocytes to Assess Cardiovascular Health

Researchers at the University of California, Davis have developed a microfluidic device that measures cardiovascular disease risk by quantifying the frequency of adherent monocytes in blood and assessing the activation level of circulating inflammatory cells.

Novel Auditory Diagnostic

Researchers at the University of California, Davis, have developed a novel diagnostic for the auditory system.

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