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Holographic Opto-Fluidic Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a system for holographic opto-fluidic microscopy.

High-Throughput And Label-Free Single Nanoparticle Sizing Based On Time-Resolved On-Chip Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a rapid, low-cost, and label-free methodology for nanoparticle sizing.

Microscopic Color Imaging And Calibration

UCLA researchers in the Department of Electrical Engineering have developed a color calibration method for lens-free and mobile-phone microscopy images allowing for high resolution and accurate color reproduction.

Wide-Field Imaging Of Birefringent Crystals In Synovial Fluid Using Lens-Free Polarized Microscopy For Crystal Arthropathy Diagnosis

UCLA researchers in the Department of Electrical Engineering have developed a new diagnostic tool for arthropathic diseases, such as gout.

Microbial Mediators Of The Beneficial Effects Of The Ketogenic Diet

UCLA researchers have identified a strategy to manipulate the gut microbiome to mimic the effects of a ketogenic diet, as a treatment for CNS disorders and metabolic diseases.

Transforming Growth Factor-Beta (TGF-β)-Responsive Single-Chain Variable Fragments And Chimeric Antigen Receptors

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed chimeric antigen receptors that are responsive to human and mouse TGF-β (Transforming Growth Factor-Beta).

Use Of Specific Molecules In Prediction Of Pregnancy Outcome

A UCLA physician has discovered a novel method to screen for embryonic genetic competency during the in vitro fertilization process by using the free DNA released from a candidate embryo.

Process For Recycling Surfactant In Nanoemulsion Production

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method to separate and recycle surfactants used in the manufacturing of nanoemulsions.

Combination Of Approved Alzheimer's Drugs With Metabolic Enhancement For Neurodegeneration (MEND) To Comprise A Therapeutic System

UCLA researchers in the Department of Neurology have developed a novel therapeutic program for Alzheimer’s disease, based on the combination of existing AD drugs and a program to enhance metabolic activity.

Nucleic Acid Tetramers For High Efficiency Multiplexed Cell Sorting

UCLA researchers in the Departments of Medicine and Pharmacology have a highly specific method of sorting cells by using multiplexed tetramers with unique DNA-oligomer signatures.

Drop-Carrier Particles For Digital Assays

UCLA researchers in the Department of Bioengineering have developed a novel drop-carrier particle for single cell or single molecule assays.

Alpha1–2-Fucosyltransferase for Enzymatic Synthesis of Alpha1–2-linked Fucosylated Glycans

Researchers at the University of California, Davis have discovered an alpha1–2-fucosyltransferase that efficiently catalyzes the synthesis of alpha1–2-linked fucosylated glycans that can contain different internal glycans.

Therapeutic Vaccine for Chronic Hepatitis B (CHB)

Researchers at the University of California, Davis have developed a therapeutic vaccine capsule against Chronic hepatitis B.

CRISPR/Cas9 Mediated Genome Editing For Duchenne Muscular Dystrophy

UCLA researchers in the Department of Microbiology, Immunology & Molecular Genetics have developed a method to permanently correct the out-of-frame dystrophin gene in patient cell models of Duchenne Muscular Dystrophy (DMD)

Stimuli Responsive Immunostimulants

An immune response typically occurs during inflammation, auto-immune diseases, or cancers. In such cases, chemical triggers, or immunostimulants, recognized by receptor proteins at cell membranes activate the immune cells. Researchers can use these immunostimulants to test how different cell subsets contribute to immune response mechanisms. This invention describes a novel type of immunostimulant that can be toggled on and off, both inside the body and in vitro.

Ligands for Improved Angiogenesis and Endothelialization of Blood Contacting Devices

Researchers at the University of California, Davis have discovered novel targeting ligands that can specifically bind and capture endothelial cells and endothelial progenitors for improved endothelialization and angiogenesis of medical devices and scaffolds.

Protein Target for Prostate Cancers

Researchers at the University of California, Davis have identified a unique protein target for the development of therapies for advanced prostate cancers.

Re-Sensitizing Cancer Cells to Anticancer Drugs

Researchers at the University of California, Davis have discovered a new class of ROR-γ inhibitors which can reduce and reverse cancer cell resistance to anticancer drugs.

Novel Solid Tumor Chemodrug LLS2

Researchers at the University of California, Davis have developed a new library of small molecule LLS2 that can kill a variety of cancer cells

Molecular Algorithm for Intragraft Assessment of Cardiac Allograft Rejection

UCLA researchers in the Department of Medicine have developed a methodology that improves the classification of endomyocardial biopsy-based data gathered from gene expression profiles and clinical phenotypes.

Electronically controllable laser and point location system for body worn laser therapeutic systems

Photonic physiological and neurological stimulation is the application of therapeutic lasers to classical acupuncture points on the body for therapeutic purposes. The therapy is typically delivered with a manually held and adjusted laser, which can be inexact and unsteady. Working together, inventors at UCI and Samueli Institute have developed a computer-controlled photonic stimulation system that is capable of using complex therapy protocols to provide more effective treatment using multiple laser sources.

Devices and systems using signal processing algorithms to improve speech intelligibility and listening comfort

The present invention relates generally to the fields of bioengineering and medicine and more particularly to methods, devices and systems that use signal processing algorithms to improve hearing in hearing impaired subjects. Methods, devices and systems for improving hearing and for treating hearing disorders, such as auditory neuropathies. A hearing enhancement system of this invention generally comprises; an amplitude modulation processor, a frequency high-pass processor, a frequency upward-shifting processor and a formant upward-shifting processor.

METHOD AND APPARATUS FOR ADAPTING SPEECH CODERS TO IMPROVE COCHLEAR IMPLANT PERFORMANCE

The present invention relates generally to speech processing strategies, and more particularly to adapting speech coders to improve the performance of cochlear implants. Cochlear implant performance is improved by extracting pitch information and encoding such pitch information into the processor of a cochlear implant. One embodiment of the invention is to explicitly extract the pitch and deliver it to the cochlear implant by co-varying the stimulated site and rate. Another embodiment of the invention is to implicitly encode the pitch information via a code book that serves as the carrier of stimulation in the cochlear implant.

microfluidic device for preparation of monodisperse microcapsules and microvesicles

Many applications, ranging from in vivo cell culture growth to drug delivery, rely on microcapsules to encapsulate and protect cells or molecules until their desired release. These microcapsules are typically generated in immiscible fluid, which must be depleted before they can be effectively used. Researchers at UCI have recently developed a paper-based microcapsule extraction technique that is quicker, cheaper, and less damaging than conventional methods.

SIMPLE AND RAPID METHOD FOR QUANTIFICATION OF HALOGINATED DISACCHARIDES, SUCH AS SUCRALOSE, IN AQUEOUS MEDIA

Sucralose has become widely used as an artificial sweetener due in large part that it has low caloric content and is 600 times sweeter than table sugar (sucrose). Due to its resistance to metabolic degradation, sucralose can also be used as a marker for noninvasively assessing gastrointestinal small intestine or colonic permeability. This urinary marker is traditionally analyzed by time consuming and expensive methods, such as high performance liquid chromatography coupled to mass spectrometry or evaporative light scatter as the detectors. We have developed an alternative methodology of using a chemical-fluorescent technique for rapid analysis of halogenated disaccharides, such as sucralose.

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