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Non-Invasive Thermal Calorimetric Method For Estimating Blood Flow In Extremities Especially The Diabetic Foot

Background: The CDC estimated that diabetes costed the US $245B in 2012, with 1.7M new diagnoses every year. As the prevalence continues to grow, a better means to monitor diabetes and prevent furthering the condition is needed. Among many complications, foot ulcers are the most common and is a result of constricted blood flow to the lower extremities. There is great traffic in the market for preventing diabetic foot ulcers with growth projections of $1.6B by 2017.   Brief Description: UCR researchers have developed a novel, non-invasive method for monitoring blood flow in the lower extremities. They incorporated thermal monitors plus a computer chip into a boot-like device. Now a diabetic patient can simply insert their foot into the device to measure blood flow rate. The current method to obtain blood flow information is with Doppler ultrasound, which is costly and requires a skilled technician in a hospital setting. The boot device can serve potentially as an at-home diagnostic monitor that will help patients become more actively aware of their condition, and with physician’s guidance prevent the diabetic foot from advancing to more serious complications.

Regulating the Microbiome with Disease-Associated Genes

Background: Inflammatory Bowel Disease (IBD) is a chronic condition with substantial health and economic costs, affecting 1.3M people in the US. Currently, there is a lack of precise understanding of IBD and therefore, many are misdiagnosed or not even diagnosed at all. There is a high demand for effective and preventative therapies to reduce the burdens of IBD. Most of the time, patients have to resort to surgery which is a very expensive and invasive process. The IBD market is expected to be $9.6B in 2017 and is projected to show robust growth due to increasing IBD prevalence.   Brief Description: UCR researchers have discovered a novel gene that can be modulated to control the microbiome. It is also the first evidence of identifying a specific bacteria in a mouse model of human disease. This discovery will allow for insight into how and which human disease-associated genes are involved in modifying the microbiome to offer better therapeutic solutions in alleviating the disease.

Piezo Scaler With Laser Capabilities

A power driven dental device that utilizes light & sound to remove deposits from the teeth, reduce bacterial loads, and promote soft tissue healing while preventing disease transfer both inside and outside the oral cavity.

Engineered-Microparticle-Based Cell Carriers For Culture And Adhesive Flow Cytometry

The Di Carlo group at UCLA has invented a microparticle that enables the analysis of adherent cells by flow cytometry. In addition, they have developed a high-throughput method to fabricate these microparticles.

Synthesis of Lipobactins and Teixobactin Analogues – New Antimicrobial Compositions against Gram-Positive Bacteria

With the discovery of penicillin in the 1940’s, many scientists proclaimed the defeat of infectious diseases which had plagued mankind. However, the remarkable healing power of antibiotics unfortunately invited widespread and indiscriminate use of antibiotics. This misuse and overuse of antibiotics has led to the dramatic rise in antibiotic resistant bacterial strains and increased healthcare costs.

Injectable Magnetic Nanocomposite Implants For Tissue Repair

Background: In 2014, the orthopedic soft tissue repair market was $10.3B, and is expected to grow due to an increasing number of soft tissue injuries with very few alternatives to surgery. Current procedures are very invasive, and require drilling holes followed by bone marrow extraction to repair the damaged tissue. Not only is the procedure costly, but the patient is held in recovery for a very long period of time.  Brief Description: UCR researchers have developed 3D magnetic nanocomposite scaffolds that can be injected into the target site for improved tissue regeneration and healing. The material can fill any shape or size of the defective site in just 2 injections. The first injection targets subchondral bone followed by a second injection that promotes cartilage regeneration. This novel invention will allow the patient to save costs incurred on surgical procedures, and regain full functionality under a shorter recovery time.

Methods for Disrupting HIV Latency Using Anti-HIV Latency Agents

Researchers at the University of California, Davis have developed methods for reactivating latent viral infection in peripheral blood samples of human immunodeficiency virus (HIV)-infected individuals receiving anti-retroviral therapy and for optimizing the process by including additional reactivation agents.

Protein-Graphene Hybrid Supercapacitor

A protein-graphene hybrid supercapacitor that offers greater capacitance, programmability, and consistency at lower cost than current supercapacitors.

Stimulus-responsive Polymers

Synthetic polymer constructs are an important tool in modern medical practice, but the lack of control over their activity limits their utility. The ability to combine structural function with localized interaction has proven extremely successful in stents, but polymer technology has not advanced sufficiently to serve a wider range of needs. PLGA polyesters can be degraded by hydrolysis facilitating their widespread use in medicine and biomedical research. Their dependence on slow hydrolysis makes for long degradation times (half-life of one year in vivo) limiting their applicability. While degradation can be sped up by copolymerization with more hydrophilic monomers; degradation is still too slow for triggered release or degradation.

Artery-on-a-Chip for Capturing Inflammatory Monocytes to Assess Cardiovascular Health

Researchers at the University of California, Davis have developed a microfluidic device that measures cardiovascular disease risk by quantifying the frequency of adherent monocytes in blood and assessing the activation level of circulating inflammatory cells.

Novel Auditory Diagnostic

Researchers at the University of California, Davis, have developed a novel diagnostic for the auditory system.

STRUCTURAL AND MECHANICAL CHANGES TO JOINT CAPSULES, TENDONS AND LIGAMENTS

Technology is designed to treat diseases of the joints (joint capsules specifically), tendon and ligament disorders.

Molecular Photoswitches as MRI Contrast Agents Sensitive to Light/Bioluminescence

Researchers at the University of California, Davis have developed a light-activated gadolinium contrast agent.

Novel Hydrogel for Optimized Cell Delivery, Culture and Inflammation Prevention from De-cellularized Human Amniotic Membrane

A novel, human amnion derived hydrogel has been shown to considerably optimize cell delivery and scaffolding by increasing cellular survival, proliferation, and integration, as well as significantly decreasing host rejection and morbidity.

Microfabricated Silicon-Based Hollow Microneedles with Integrated Fluid Channels for Transdermal Fluid

Research conducted at the University of California, Davis has led to an improved method and apparatus for puncturing a surface for extraction, in situ monitoring, and substance delivery.

Nanoporphyrin Nanoparticles for Combination Phototherapy and Drug Delivery to Infantile Hemangiomas

Researchers at the University of California Davis have developed a novel treatment method that combines photodynamic therapy and the therapeutic compound propranolol using a nanoparticle platform to treat infantile hemangiomas (IH).

Directed Facial Nerve Stimulation

An implantable medical device for stimulating the damaged facial nerve of a patient with permanent facial paralysis. The technology affords control of nerve fibers that contribute to facial movements, such as blinking and smiling, and facial expression of emotion.

Delivery Module for Delivering Biotherapeutics Throughout the Body

Researchers at the University of California, Davis have developed a robust and broadly applicable system for the delivery of peptide and oligonucleotide biotherapeutics.

UCLA Inventors Create Platform Technology to Create Customizable Nanoscale Wound Management Tools

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale vesicles and hydrogels for use in wound management. The poly-peptide based platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, be loaded with hydrophobic, hydrophilic, or cellular payloads, adaptable to specific delivery locations, low toxicity, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis. The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can be used to augment existing material systems.

A Self-Regenerative Hybrid Tissue Structure For 3D fabrication of heart valves, blood vessels and other constructs / Mesh enclosed tissue constructs

Current tissue engineered constructs face drawbacks such as structural vulnerability, functionality, and a lack of mechanical properties. A continual need for a tissue constructs that can resist the physiological forces within the body, while being biocompatible, persists. Researchers at UC Irvine have developed a tissue construct composed of a multi-layered tissue enclosed on a metal mesh that addresses the drawbacks experienced by other developed solutions.

Cardiomyocyte Maturation Platform

The invention is a methods platform used to mature cardiomyocytes (“CMs”). The invention utilizes a cardiac microenvironment to induce and promote maturation of cardiomyocytes. The invention exposes cardiomyocytes in vitro to conditions similar to their natural environment, such as to a three-dimensional scaffold of cardiac extracellular matrix (ECM) and other cell types including endothelial cells and stromal cells. These interactions between the cells, ECM, and environment are known to promote cardiomyocyte maturation in vivo. Through the invention, the CMs will mature in vitro at a rapid rate faster than they would normally mature in vivo.

Pediatric Resuscitation and Ventilation Monitor

Researchers at the University of California, Davis have developed a pediatric resuscitation monitor that allows for proper ventilation rate and tidal volume based on a patient’s age and height. This system will help first responders and emergency physicians provide optimal ventilation to pediatric patients during emergency resuscitation.

Hyaluronic Acid-based Gel for Topical and Subcutaneous Applications

A method for producing chemically-crosslinked hydrogels using a biocompatible “click” chemistry for in situ gelation. 

Soft Tissue Gripping Device

Nerve injury in the Peripheral Nervous System is caused by trauma, vehicular accidents, repetitive stress, and wartime injuries and affects up to 1% of the U.S. population by age 70. Severed nerves lead to severe pain or the lack of sensation and mobility.

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