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Nanoporphyrin Nanoparticles for Combination Phototherapy and Drug Delivery to Infantile Hemangiomas

Researchers at the University of California Davis have developed a novel treatment method that combines photodynamic therapy and the therapeutic compound propranolol using a nanoparticle platform to treat infantile hemangiomas (IH).

Directed Facial Nerve Stimulation

An implantable medical device for stimulating the damaged facial nerve of a patient with permanent facial paralysis. The technology affords control of nerve fibers that contribute to facial movements, such as blinking and smiling, and facial expression of emotion.

A High-Throughput Screen For Drug And Disease Investigations In A Simple Neuronal Culture

Drug discovery and development consists of an arduous testing process, and cell-based screening methods represent a crucial source of information in the decision making process to evaluate mode of action, efficacy and toxicity for new therapeutics in early phases if preclinical drug development. Despite advances in cell-based screening assays, a need remains for newer and better assays to identify and validate drug s for treatment and/or prevention of neuronal diseases. Such newer assays should have a higher speed, lower cost, high sensitivity and high signal to noise ratio. Further, there needs to be improved methods for assessing toxicity of drug candidates.

Delivery Module for Delivering Biotherapeutics Throughout the Body

Researchers at the University of California, Davis have developed a robust and broadly applicable system for the delivery of peptide and oligonucleotide biotherapeutics.

UCLA Inventors Create Platform Technology to Create Customizable Nanoscale Wound Management Tools

UCLA researchers in the Departments of Chemistry, Physics, and Bioengineering, led by Dr. Tim Deming of the Bioengineering department, have developed a platform to create and modify nanoscale vesicles and hydrogels for use in wound management. The poly-peptide based platforms created by the Deming group are customizable in nearly all physical characteristics, can be tailored in size, be loaded with hydrophobic, hydrophilic, or cellular payloads, adaptable to specific delivery locations, low toxicity, are fully synthetic, possess highly reproducible properties, and are inexpensive to prepare compared to solid-phase peptide synthesis. The platform can be used to create novel, need-based nanoscale vesicles or injectable hydrogels, and can be used to augment existing material systems.

A Self-Regenerative Hybrid Tissue Structure For 3D fabrication of heart valves, blood vessels and other constructs / Mesh enclosed tissue constructs

Current tissue engineered constructs face drawbacks such as structural vulnerability, functionality, and a lack of mechanical properties. A continual need for a tissue constructs that can resist the physiological forces within the body, while being biocompatible, persists. Researchers at UC Irvine have developed a tissue construct composed of a multi-layered tissue enclosed on a metal mesh that addresses the drawbacks experienced by other developed solutions.

Topical Drugs To Reduce Excessive Hair Growth

Excessive hair disorders (hypertrichosis, hirsutism) can have severe impact on an individual's self-esteem and ability to interact successfully in the workplace and social settings.  Existing therapies, with a potential for long-term hair removal, include laser therapy and/or electrolysis.  These require multiple courses, are expensive and may not be fully or permanently effective.  While hirsutism may respond to medical/hormonal therapies, such as oral contraceptive pills (OCPs), glucocorticoids, or antiandrogens such as spironolactone, these often have adverse side effects such as fatigue, pain, weight gain, depression.  Furthermore, many patients find that they still require laser or electrolysis in addition to medical therapy.  Therefore there is a large unmet need for safe, simple and cost-effective treatments for hypertrichosis.

Pediatric Resuscitation and Ventilation Monitor

Researchers at the University of California, Davis have developed a pediatric resuscitation monitor that allows for proper ventilation rate and tidal volume based on a patient’s age and height. This system will help first responders and emergency physicians provide optimal ventilation to pediatric patients during emergency resuscitation.

Hyaluronic Acid-based Gel for Topical and Subcutaneous Applications

A method for producing chemically-crosslinked hydrogels using a biocompatible “click” chemistry for in situ gelation. 

Soft Tissue Gripping Device

Nerve injury in the Peripheral Nervous System is caused by trauma, vehicular accidents, repetitive stress, and wartime injuries and affects up to 1% of the U.S. population by age 70. Severed nerves lead to severe pain or the lack of sensation and mobility.

Apparatus for Growing a Heart Valve in 3D

This invention is a procedure and apparatus used to grow and shape three-dimensional heart valves tissues.

Lateral Cavity Acoustic Transducer Based Microfluidic Switch

The ability for on-chip particle/cell manipulation is important for microfluidic applications. Researchers at UC Irvine have developed a technology that exploits the phenomenon of acoustic microstreaming to manipulate fluid flow and suspended cells/particles in a microfluidic environment.

Multilayer High Density Microwells

Researchers at UC Irvine have developed high density, three dimensional (3D) micro-reactors for digital biology applications. The high-density imaging arrays overcome drawbacks associated with existing high density arrays fabricated on a single surface and the more recent 3D droplet emulsion arrays.

Direct Drive Micro Hearing Device

The current state of art does not provide a satisfactory way to restore hearing without one or more of the following disadvantages; feedback, occlusion effects, easily visible, stigma, invasive surgery, expensive and/or surgery for removal. Thus, there exists a desire for a device which overcomes one or more of the aforementioned drawbacks

New Inhibitors of the HIV Protease

Drug resistance is one of the key roadblocks towards successful treatment of AIDS. Although numerous drugs have been developed to target various viral proteins, resistant viral strains are selected in the presence of the drug to become dominant in the population, therefore severely impairing drug efficacy and increasing the cost of treatment. There is an unmet need to develop strategies to combat drug resistance.

Device for Creating Stoma with Desired Characteristics

Physicians from UCLA Department of Surgery conceptualized a device for creating clean stomata that involves a circular saw and a mechanism for stretching the skin to specific tension.

Improvements of cognitive function in age-related disorders and Alzheimer's disease

Cognitive deficits associated with aging and other age-related disorders involve deficits in processing sensory information, attention, consolidation of memory, recall of information, and executive functions such as planning, problem solving and self-monitoring among others. There is a large unmet medical need to identify therapies and novel therapeutic regimes for the treatment of cognitive dysfunction, e.g., cognitive deficits related to aging, age-related disorders and Alzheimer's disease. Previously published research suggests a correlation between neurological disorders and trimethylation of histone H3K9 in the brain. Therefore, an inhibitor of histone methyl transferase SUV39h1 and its effects on the progression of age-related disorders was investigated.

An integrated intraoperative diagnosis and therapy catheter system

In traditional cardiology and oncology, disease diagnosis and treatment are traditionally separate procedures resulting in increased costs and delayed treatment, which, in some cases, may increase morbidity. Therefore, a system that can diagnose and treat diseases simultaneously would greatly decrease costs and provide timely treatment, which may prevent death from the disease. Researchers in the Department of Engineering at UC Irvine, in collaboration with researchers at Shanghai Jio Tong University in China have invented a multimodal system for the diagnosis and treatment of cancer and cardiac disease. Summary of development The present invention describes an intraoperative imaging and therapy catheter system for the accurate diagnosis and treatment of cancer and cardiac disease. This multimodal medical device combines imaging, cryosurgery, and thermal therapy thereby permitting accurate diagnosis and treatment of vulnerable plaques in blood vessels and various types of cancers. In addition, by adding low cost imaging modalities such as optical coherence tomography (OCT), ultrasound imaging, photoacoustic (PA) imaging, fluorescence imaging and thermal imaging, cryosurgery can be performed with much higher accuracy. Importantly, addition of these imaging systems enables accurate identification of lesion sites, precise depth of cryosurgery/heating probe placement, and the capability to monitor the extent of the freezing/heating process. Furthermore, the invention may include intravascular ultrasound (IVUS) facilitating visualization of cross-sectional images of the vessel wall, entire large lipid pools, and large tumor regions. These parameters are valuable for the guidance of cryoplasty regarding the treatment time, temperature and location.

A Novel Use Of Action Video Game Technology in a Digital Neurotherapeutic To Improve Impaired Human Spatial, Temporal And Quantitative Cognition

A scientifically designed evidence-based digital neurotherapeutic, in the form of a video game, has been developed to challenge, engage and improve spatiotemporal processing abilities in individuals with certain neurodevelopmental disorders and the healthy aging, as well as those with some forms of acquired brain damage.

Method For Estimating The Need For Surgical Care (Or Any Other Health Care Intervention) In A Population

The need for surgical care (or any health care intervention) varies across demographics within a population because epidemiology of disease varies.  For example, demographics with higher fertility rates require more surgical procedures to address maternal health problems such as obstructed labor.  The same applies to all other diagnoses that require surgical care such as injuries, congenital anomalies and non-communicable disease.  One of the challenges of planning surgical care for a population (or any other element of health care) is to how to estimate need.  Estimating need can be used to cost interventions as well as to measure the financial impact of health care investments.  However, previous efforts to integrate surgical services into global health initiatives do not reflect the scope of surgical need and many health systems do not provide essential interventions.

A Method To Modulate The Pathologic Multireceptor Signaling Via The Giv-Gi Axis In Diverse Diseases / 2015-082

Most common diseases, e.g., cancer, inflammation, diabetes are driven by multiple cell surface receptors that trigger and sustain a pathologic signaling network. The largest fraction of therapeutic agents that target individual receptors/pathways often eventually fail due to the emergence of compensatory mechanisms. Recently, UCSD researchers identified GIV protein as a central platform for receptor cross-talk which integrates signals downstream of a myriad of upstream receptors, and modulates several key pathways within downstream signaling network, all via activation of trimeric G proteins. The researchers have conducted proof-of-concept studies demonstrating that non-genetic exogenous modulation of the GIV-Gi signaling interface using cell-penetrable synthetic GIV-derived peptides is an effective strategy to reset pathologic signaling networks downstream multiple receptors in a diverse array of pathophysiologic conditions.

Predicting Metabolic Side Effects Of Transported Drugs

Drug clearance is the important process by which a drug and/or its metabolites are eliminated from an organism.  When drug clearance is excessive, efficacy of the drug may not be achieved; when drug clearance is inadequate, toxicity to the organism may result.  Members of the solute carrier (SLC) and ATP-binding cassette (ABC) “drug” transporter families  have  well-established roles in absorbing, distributing, and eliminating xenobiotics such as drugs. In addition, there is growing evidence for suggesting that these transporters also transport metabolites, nutrients, signaling molecules, and antioxidants at the organismal and cellular levels. Competition of drugs with metabolites at the level of transporters involved in absorption, distribution, and elimination of drugs and metabolites can lead to major metabolic side effects over the long term.  Owing to the tremendous clinical importance of these transporters, there is a need to combine metabolic reconstruction (systems biology) methods with computational (pharmaceutical) chemistry, as well as wet lab validation to study these transporters of the SLC and ABC family and drug-induced metabolic changes.

An Adaptive Mobile Momentary Assessment System for Real-Time Assessment and Health Interventions

High frequency data collection in a participant’s usual environment (ecological momentary assessment, or EMA) offers a promising approach for understanding, and potentially intervening on, the precursors of clinically important states and behaviors in mental health disorders.  

An Adaptive Mobile Momentary Assessment System for Real-Time Assessment and Health Interventions

High frequency data collection in a participant’s usual environment (ecological momentary assessment, or EMA) offers a promising approach for understanding, and potentially intervening on, the precursors of clinically important states and behaviors in mental health disorders.  

Methods of Disease Modeling

Identification and evaluation of new therapeutic agents and the identification of suspected disease targets (which typically employ animal models) are expensive, time consuming, etc.  In vitro alternatives have relied on the use of conventional cell culture systems which are limited in that they do not allow the three-dimensional interactions that occur between cells and their surrounding tissue. Additionally, cells not only sense and respond to chemical cues, they also respond to the physical environments. 

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