Brief description not available

Brief description not available

The challenge in utilizing α-Linolenic acid (ALA) for medical adhesives has been its poor water solubility and the high hydrophobicity of poly(ALA), typically necessitating elevated temperatures, organic solvents, or complex preparation methods for tissue application. UC Berkeley researchers have developed ALA-based powder and low-viscosity liquid superglues that overcome this limitation by polymerizing and bonding rapidly upon contact with wet tissue. The versatile adhesives are formulated using a monomeric mixture of ALA, sodium lipoate, and an activated ester of lipoic acid. These adhesives demonstrate high flexibility, cell and tissue compatibility, biodegradability, and potential for sustained drug delivery as a small molecule regenerative drug was successfully incorporated and released without altering the adhesive's properties. Additionally, the inherent ionic nature of the adhesives provides high electric conductivity and sensitivity to deformation, enabling their use as a tissue-adherent strain sensor.

Current α-linolenic acid (ALA)-based medical adhesives are limited by ALA's poor water solubility and poly(ALA)'s hydrophobicity, often requiring elevated temperatures, organic solvents, or complex preparations for delivery to biological tissue. This innovation reports on ALA-based powder and low-viscosity liquid superglues that polymerize and bond rapidly upon contact with wet tissue. Developed by UC Berkeley researchers, the versatile adhesives use a monomeric mixture of ALA, sodium lipoate, and an activated ester of lipoic acid, which grants them high flexibility as confirmed by stress-strain measurements on wet adhesives. The adhesive is cell and tissue-compatible, biodegradable, and can sustain drug delivery as a small molecule regenerative drug was successfully incorporated and released without altering its physical or adhesive properties. Furthermore, the inherent ionic nature of the adhesive gives it high electric conductivity and sensitivity to deformation, enabling its use as a tissue-adherent strain sensor.

Current methods for 3D printing high-resolution, large-scale designs often face a trade-off between feature size and build area, limiting the scalability of intricate structures. This invention developed by UC Berkeley researchers addresses this by providing a scanning projection system and related method that enables high-resolution, large-scale 3D printing. The system achieves this by employing an advanced optical train with moving optics to project a final image onto a curable resin located on a projection plane. The optical system includes an illumination device, a collimating lens, a first movable reflection mirror, a movable focusing lens, a second movable reflection mirror, and a movable projection lens. By mounting one or more parts of this system on motion stages, the system can scan and project a final image across a large area while maintaining a fine feature size (e.g., 20 micrometers). This approach offers superior resolution and scalability compared to fixed-optics systems, potentially enabling the fabrication of complex structures for applications previously constrained by size or detail limitations.

Researchers at the University of California, Davis have developed metal oxynitride compounds with reduced defect levels that enable improved solar energy conversion efficiency and higher stability than silicon under harsh conditions.

Researchers at the University of California, Davis have developed an innovative Cherenkov-based system for calibrating radiotherapy beams, enabling precise, real-time calibration of radiation dose delivery, including for high-intensity FLASH radiotherapy, improving treatment accuracy and reliability.

Researchers at the University of California, Davis have developed a technology that introduces vaccines that express macrophage-suppressing molecules to significantly enhance inflammatory T-cell functions for improved immune responses.