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Researchers at the University of California, Davis have developed a biosensor technology for rapid, sensitive detection, purification, and identification of nucleic acids in complex biological fluids.

CRISPR-derived nucleases offer unprecedented precision and ease of use for targeting specific genomic sites. However, the efficient delivery of gene editing tools into plant cells remains a significant hurdle. Current methods rely on a laborious and time-consuming tissue culture pipeline and can induce undesirable changes to the genome and epigenome. To circumvent these limitations, one alternative is to use plant viral vectors for the delivery of compact gene editors and their guide RNA (gRNA). UC Berkeley and UC Davis inventors found that the use of tobacco rattle virus (TRV) vectors to deliver reRNA and variant TnpB proteins to plants results in surprisingly high efficiencies of genome editing not only in the infiltrated cells, but also systemically (e.g., seeds and non-infiltrated leaves). Delivery via TRV caused systemic viral spread into the shoot apical and floral meristematic regions, leading to unexpectedly high efficiencies of genome editing in non-infiltrated cells (i.e., spread of genome editing), for example, surprisingly high efficiencies of genome editing in non-infiltrated systemic leaves as well as in the germline (e.g., seeds).

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An innovative, nature-inspired system that efficiently captures, transports, and stores fluids while providing passive cooling through controlled fluid dynamics.

Researchers at the University of California, Davis have developed a peptide nucleic acid-based system enabling precise and customizable delivery of antigens, adjuvants, and targeting molecules for improved cancer immunotherapy.

Researchers at the University of California, Davis have developed novel serotonin receptor modulators designed as mixed 5-HT2A/2C partial agonists that demonstrate promising disease-modifying potential for Parkinson’s Disease with improved safety and efficacy.