Background: Biomolecular imaging is important in understanding characteristics of molecules and analyzing quantitative data for research. Gold has been used for Surface Plasmon Resonance (SPR) which is utilized for biomolecular imaging. Because of Gold’s high stability structurally and chemically, it is resourceful in this sort of technology. Compared to Gold, Silver does not have as strong of a stability in non ideal chemical environments, but has high reactivity, supports strong surface plasmon polarization modes, and has higher storage of electrical energy than Gold.Description: UCR researchers have created Silver-Gold alloy nanospheres through annealing techniques which may be used in SPR that creates optimal and effective results. By annealing the Silver and Gold metal alloy, it has shown remarkable stability in harsh chemical environments, extremely narrow bandwidths, and shows large extinction pathways. These specific characteristics enable many plasmonic applications with high performance and long lifetime, especially any involving corrosive species making the Silver-Gold alloy the most favorable choice for SPR.