Antiretroviral therapy (ART) has substantially reduced the morbidity and mortality rates of HIV-1 infection, the persistence of viral reservoirs continues to prevent the elimination of HIV-1 from all tissue compartments. Consequently, there is still a need for point of care (POC) tests of circulating HIV levels (viral load) that do not rely on expensive technologies such as PCR.
UCSF Investigators have identified CD30, a stable, soluble protein as a surrogate biomarker for HIV-1 RNA, and are developing a POC assay for widespread distribution and use.
HIV-1, central nervous system, CNS, cerebrospinal fluid (CSF), CD30, point of care, viral reservoir, biomarker