Gene Targets For Gamma-Delta T Cell Cytotoxicity Against Tumor Cells

Tech ID: 33262 / UC Case 2020-154-0

Technology Description

Using a genome-wide knockout screen in target tumor cells, UCSF Investigators have identified cellular factors that influence gamma-delta T cell cytotoxicity against target cells, and developed methods for modulating expression of these factors. One of the top genetic hits is of particular importance since it is a cell surface protein that has not been previously implicated in this interaction. These methods have great therapeutic potential and may lead to treatments for a variety of diseases, including cancer, autoimmune diseases, bone disorders, metabolic disorders, and infectious diseases.

Patent Status

Patent Pending

Related Materials


Learn About UC TechAlerts - Save Searches and receive new technology matches

Other Information

Categorized As