Gene Targets For Gamma-Delta T Cell Cytotoxicity Against Tumor Cells

Technology Description

Using a genome-wide knockout screen in target tumor cells, UCSF Investigators have identified cellular factors that influence gamma-delta T cell cytotoxicity against target cells, and developed methods for modulating expression of these factors. One of the top genetic hits is of particular importance since it is a cell surface protein that has not been previously implicated in this interaction. These methods have great therapeutic potential and may lead to treatments for a variety of diseases, including cancer, autoimmune diseases, bone disorders, metabolic disorders, and infectious diseases.

Patent Status

Patent Pending

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