Gene Targets For Manipulating T Cell Behavior

Tech ID: 33261 / UC Case 2020-043-0

Technology Description

By performing non-viral pooled knock-in screens, UCSF investigators have discovered novel genes that improve T cell functionality across a variety of in vitro assays. This invention includes novel compositions and methods for modifying the genome of a T cell to alter its specific and functionality, while limiting the side effects associated with T cell therapies. 

Technology Advantages:

  • Identifies novel gene targets 
  • Potential to enhance therapeutic potency of T cells for cancer and autoimmune applications


Patent Status

Country Type Number Dated Case
Japan Published Application 2023-544161 11/30/2023 2020-203

Additional Patents Pending


Learn About UC TechAlerts - Save Searches and receive new technology matches

Other Information


T cell therapy, Cancer, Immunotherapy

Categorized As