Gene Targets For Manipulating T Cell Behavior

Technology Description

By performing non-viral pooled knock-in screens, UCSF investigators have discovered novel genes that improve T cell functionality across a variety of in vitro assays. This invention includes novel compositions and methods for modifying the genome of a T cell to alter its specific and functionality, while limiting the side effects associated with T cell therapies. 

Technology Advantages:

• Identifies novel gene targets 
• Potential to enhance therapeutic potency of T cells for cancer and autoimmune applications

Patent Status

Patent Pending