LONG NON-CODING RNAS (LNCRNAS) AS THERAPEUTIC TARGETS IN GLIOMA

Technology Description

LncRNAs exhibit high specificity to target tissues and cells, which may help to reduce toxic effects associated with cancer therapy. LncRNAs can be successfully targeted with antisense oligonucleotides (ASOs) to represent a new class of targets for tumor therapy.

UCSF researchers have developed a radiation modifier screen using CRISPRi to identify specific lncRNAs that sensitize glioma cells to radiotherapy. The invention also comprises methods for generating a human brain organoid model of malignant glioma.

Advantages

· Potential to:

o increase efficacy of radiation therapy, a key adjunctive cancer therapy

o selectively inhibit glioma cell growth via lncRNA knockdown without toxicity to normal brain cells

Application

· Method of treating malignant glioma and/or inhibiting growth / proliferation of glioma cells

· Enhancement of radiation therapy efficacy

· Method of screening therapeutic agents / radiotherapy sensitizers

Looking for Partners

To commercialize the technology

Stage of Development

Proof of concept

Related Materials

• Compositions and Methods of Treating Glioma - 04/11/2023

Data Availability

Available under CDA

Patent Status

Patent Pending