Systems And Methods For Performing Peptide Exchange Reactions Using Placeholder Peptides And Catalytic Amounts Of The Molecular Chaperone TAPBPR

Tech ID: 33064 / UC Case 2020-297-0


Tech ID 32985/Case number 2018-408 describes the generation of E. coli expressed, peptide receptive MHC-I monomers and multimers using the TAPBPR chaperone. 

In this case, the technology was improved based upon the surprising discovery that the TAPBPR chaperone acts catalytically on MHC-I-placeholder peptide complexes to create peptide receptive MHC-I species. 

Technology Description

Technology is identical to that described in 2018-408-0, except that the ratio of TAPBPR to MHC-I-placeholder peptide complex is less than 1:1. As low as a 1:10,000 ratio of TAPBPR to MHC-I placeholder peptide can be used without an effect on the overall reaction time. 


Peptide receptive MHC-I multimer reagents

MHC-I reagents

Identifying antigenic peptides 

Identifying and purifying T cell populations 




Improved cost effectiveness of making MHC Class I reagents because less of the TAPBPR component needs to be made.  


Additional patent claims close off potential loophole in coverage 

Intellectual Property Information

Country Type Number Dated Case
United States Of America Published Application 20230059548 02/23/2023 2019-975
European Patent Office Published Application EP 4 136 098 02/22/2023 2020-284
European Patent Office Published Application 4085069 11/09/2022 2019-975
European Patent Office Published Application 4085068 11/09/2022 2020-297
European Patent Office Published Application 402841.2 07/20/2022 2020-251
United States Of America Published Application 20210371499 12/20/2021 2020-284

Additional Patents Pending

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  • Sgourakis, Nikolaos

Other Information


MHC-I, Class I MHC, Antigenic Peptide, Peptide Receptive MHC, MHC multimers, MHC tetramers, MHC reagents, Major Histocompatability Complex, Class I, Chaperone, TAPBPR, Catalytic TAPBPR

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