System for Transcatheter Grabbing and Securing the Native Mitral Valve’s Leaflet to a Prosthesis

Tech ID: 32960 / UC Case 2021-762-0

Brief Description

Researchers at UC Irvine have developed an assembly of components that work together as a system for first grabbing, and then securing the native mitral valve’s leaflet to a prosthesis via transcatheter means.

Suggested uses

·To avoid both static and dynamic transcatheter mitral valve replacement (TMVR)-induced left ventricular outflow tract obstruction (LVOT)

Features/Benefits

·To avoid both static and dynamic transcatheter mitral valve replacement (TMVR)-induced left ventricular outflow tract obstruction (LVOT)

Full Description

Left ventricular outflow tract (LVOT) obstruction is a leading cause of mortality and exclusion from transcatheter mitral valve replacement (TMVR). LVOT obstruction is a frightening TMVR complication, occurring in up to 40% of valves implanted in a native mitral annular calcification, 5% of valve-in-ring cases, and 2% of valve-in-valve cases. Potential for LVOT obstruction is the most important cause for patient exclusion for TMVR, with 49% of patients for valve implants in a native mitral annular calcification and 6% of patients for valve-in-ring excluded for TMVR due to predicted risk of LVOT obstruction.

There are two mechanisms that lead to TMVR-induced LVOT obstruction: (1) Static obstruction occurs when the native mitral valve’s anterior leaflet is pushed toward the interventricular septum by the mitral valve prosthesis, creating a narrowed and elongated “neo-LVOT;” (2) Dynamic obstruction occurs when the narrowed neo-LVOT generates Bernoulli forces that pulls the anterior mitral leaflet toward the interventricular septum during systole. A long anterior mitral leaflet with redundant chordae could be a risk factor which may also prolapse back into the transcatheterly-implanted mitral valve, interfering with valve closure and causing acute valve failure.

As a solution to avoid both static and dynamic TMVR-induced LVOT obstruction, researchers at UC Irvine have developed an assembly of components that work together as a system for first grabbing, and then securing the native mitral valve’s leaflet to a prosthesis via transcatheter means.

State Of Development

Device design is currently underway.

Other Information

Country

Type

Number

Dated

Case

United State of America

Published Application

20220273434A1

09/01/2022

2021-762



Patent Status

Country Type Number Dated Case
United States Of America Published Application 20220273434 09/01/2022 2021-762
 

Contact

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Inventors

  • Kheradvar, Arash

Other Information

Keywords

Transcatheter mitral valve replacement (TMVR), Transcatheter tricuspid valve replacement (TTVR), Left ventricular outflow tract obstruction (LVOT obstruction), Right ventricular outflow tract obstruction (RVOT obstruction), Leaflet grabbing and securing

Categorized As