Engineering Cas12a Genome Editors with Minimized Trans-Activity
Tech ID: 32640 / UC Case 2022-071-0
Patent Status
Patent Cooperation Treaty |
Published Application |
WO 2023/147240 |
08/03/2023 |
2022-071 |
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Additional Patent Pending
Brief Description
The inventors engineered a set of LbCas12a mutants through rational design and directed evolution. The engineered mutants can function as efficient genome editors with minimized trans-activity.
Suggested uses
Suggested uses for the engineered LbCas12a mutants with minimized trans-activity include:
- reduced off-target genome editing in eukaryote cells.
- development into other molecular tools for genome editing.
Advantages
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