Antibiotic to Fight Gram Negative and Resistant Bacteria

Tech ID: 32422 / UC Case 2014-148-0

Abstract

Researchers at the University of California, Davis have developed a gyramide antibiotic which is effective against Gram-negative and fluoroquinolones (FQs) resistant bacteria.

Full Description

Bacterial resistance to antibiotics is a serious public health problem facing the world right now. Many antibiotics are losing their effectiveness and development of new antibiotics has been slow. Additionally, many antibiotics are not effective against Gram-negative bacteria, or bacteria that cannot be stained by the Gram method. One such bacteria is E. coli, which is known to cause many infections. Compounds have been developed that are effective against mutant E. coli, but have no efficacy against wild-type E. coli.

Researchers at the University of California, Davis have developed a gyramide antibiotic which is effective against Gram-negative and FQ resistant bacteria. Gyramides prevent bacterial growth by inhibiting DNA gyrase, which is essential for survival. They are effective against pathogens that are Gram-negative and FQ resistant, so they can fight diseases that other antibiotics cannot. This specific DNA gyrase inhibitor has shown to not only fight mutant E coli, but also wild type E. coli.

Applications

  • Inhibitor of Bacterial DNA Gyrase

Features/Benefits

  • Effective against Gram-negative and FQ resistant bacteria Successful in halting growth of mutant and wild type E. coli

Patent Status

Country Type Number Dated Case
United States Of America Published Application 20170197981 07/13/2017 2014-148
 

Additional Patent Pending

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Inventors

  • Fensterwald, Molly
  • Moore, Jared
  • Shaw, Jared T.

Other Information

Keywords

Antibiotic, E. Coli, Bacterial resistance, Gram negative, Fluoroquinolones

Categorized As