Protein Inhibitor of Type II-A CRISPR-Cas System

Tech ID: 32335 / UC Case 2021-133-0

Patent Status

Patent Pending

Brief Description

The inventors have discovered three protein inhibitors of the type II-A CRISPR-Cas system that specifically inhibit Cas9 from staphylococcus aureus. This finding is of potential importance to many companies in the CRISPR space. 

Suggested uses

This technology can be used for developing technologies using Anti-CRISPRs.

The technology will enable safe and precise use of CRISPR-Cas9 from staphylococcus aureus.

The invention can also be used for engineering genetic circuits in mammalian cells.


Anti-CRISPRs are biomolecules that inhibit nucleic-acid targeting and/or cleavage by CRISPR-Cas systems. By controlling the CRISPR system, one could possibly ameliorate the toxicity and off-target cleavage activity. Moreover, these proteins can also serve as an antidote for instances where the use of CRISPR-Cas technology poses a safety risk.

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  • Doudna, Jennifer A.

Other Information


CRISPR, staphylococcus aureus, s. aureus

Categorized As

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