This technology can be used for developing technologies using Anti-CRISPRs.
The technology will enable safe and precise use of CRISPR-Cas9 from staphylococcus aureus.
The invention can also be used for engineering genetic circuits in mammalian cells.
Anti-CRISPRs are biomolecules that inhibit nucleic-acid targeting and/or cleavage by CRISPR-Cas systems. By controlling the CRISPR system, one could possibly ameliorate the toxicity and off-target cleavage activity. Moreover, these proteins can also serve as an antidote for instances where the use of CRISPR-Cas technology poses a safety risk.
CRISPR, staphylococcus aureus, s. aureus