Protein Inhibitor of Type II-A CRISPR-Cas System
Tech ID: 32335 / UC Case 2021-133-0
Patent Status
Patent Pending
Brief Description
The inventors have discovered three protein inhibitors of the type II-A CRISPR-Cas system that specifically inhibit Cas9 from staphylococcus aureus. This finding is of potential importance to many companies in the CRISPR space.
Suggested uses
This technology can be used for developing technologies using Anti-CRISPRs.
The technology will enable safe and precise use of CRISPR-Cas9 from staphylococcus aureus.
The invention can also be used for engineering genetic circuits in mammalian cells.
Advantages
Anti-CRISPRs are biomolecules that inhibit nucleic-acid targeting and/or cleavage by CRISPR-Cas systems. By controlling the CRISPR system, one could possibly ameliorate the toxicity and off-target cleavage activity. Moreover, these proteins can also serve as an antidote for instances where the use of CRISPR-Cas technology poses a safety risk.
Related Materials
Contact
- Terri Sale
- terri.sale@berkeley.edu
- tel: View Phone Number.
Inventors
- Doudna, Jennifer A.
Other Information
Keywords
CRISPR, staphylococcus aureus, s. aureus
Additional Technologies by these Inventors
- Methods and Compositions for Using Argonaute to Modify a Single-Stranded Target Nucleic Acid
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- Lentivirus-like Particle Delivery of CRISPR-Cas9 & Guide RNA for Gene Editing
- Cas9 Variants With Altered DNA Cleaving Activity
- Cas12-mediated DNA Detection Reporter Molecules
- Improved guide RNA and Protein Design for CasX-based Gene Editing Platform
- Cas13a/C2c2 - A Dual Function Programmable RNA Endoribonuclease
- Methods For High Signal-To-Noise Imaging Of Chromosomal Loci In Cells Using Fluorescent Cas9
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- Engineered/Variant Hyperactive CRISPR CasPhi Enzymes And Methods Of Use Thereof
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- CRISPR-CAS EFFECTOR POLYPEPTIDES AND METHODS OF USE THEREOF (CasGamma)
- Class 2 CRISPR/Cas COMPOSITIONS AND METHODS OF USE
- Compositions and Methods of Use for Variant Csy4 Endoribonucleases
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- Chimeric Cas9 Variants With Novel Engineered Enzymatic Activities
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- Methods and Compositions for Controlling Gene Expression by RNA Processing
