The present invention features a device for rapidly formatting a chemical compound library into microfluidic droplets, addressing the challenge of interfacing between the macroscale and the microscale regimes of the production of reagent libraries of chemical compounds.
Droplet microfluidics has been recognized as a potential means for employing smaller reaction volumes than possible on microtiter plates to reduce the cost of reagent experimentation and drug discoveries. However, to increase the frequency of such chemical testing through high-throughput screening, a critical hurdle is the challenge of efficiently converting a compound library from a microliter plate format to a microfluidic droplet format.
· Drug discovery
· Creating microfluidic droplets
· High-throughput screening
· Reagent experimentation
· When screening large libraries of compounds in early stages of drug discovery, the present invention can reduce reagent consumption, cost, and allow for more reactions to occur.With this invention, performing high throughput screening with a droplet library can be much faster and less expensive than current practice.