Novel Phage CRISPR-Cas Effectors and Uses Thereof
Tech ID: 31724 / UC Case 2020-066-0
Patent Status
| Country | Type | Number | Dated | Case |
| United States Of America | Issued Patent | 12,612,607 | 04/28/2026 | 2020-066 |
| European Patent Office | Published Application | 4081533 A0 | 11/02/2022 | 2020-066 |
Brief Description
UC Berkeley researchers have discovered a novel family of proteins denoted Cas12L within the Type V CRISPR Cas superfamily distantly related to CasX, CasY and other published type V sequences. These Cas12L proteins utilize a guide RNA to perform RNA-directed cleavage of DNA.
Suggested uses
- Targeted genome editing of bacterial, archaeal, and eukaryotic cells
- Transcription repression of specific genes using inactivated Cas12L
- Targeting of proteins bound to Cas12L to a specific locus of a genome
- Diagnostic applications via trans-cleavage activity
Contact
- Terri Sale
- terri.sale@berkeley.edu
- tel: View Phone Number.
Inventors
- Banfield, Jillian F.
Other Information
Keywords
CRISPR, Cas12L
