The Casp8 gene encodes a cysteinyl aspartate protease that is an essential part of the caspase activation cascade initiated by death receptors but it is also involved in preventing death receptors, Toll-like receptors TLR3 and TLR4 and T-cell receptors from inducing necroptosis. Caspase-8 also is essential for mouse development.
These mice possess loxP sites on either side of exon 3 of the targeted Casp8 gene. Mice that are homozygous for this allele are viable and fertile. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exon 3 deleted in the cre-expressing tissues.
These floxed mutant mice possess loxP sites flanking exon 3 of the Casp8 gene. This strain may be useful for generating conditional mutations in applications related to apoptosis, necrosis, inflammation and immunity.
The mice are designated Tangible Research Material (TRM). A complete description, including genotyping, phenotyping, etc is found at The Jackson Lab cat. No.027002; https://www.jax.org/strain/027002
Academic and non-profit institutions please order directly from The Jackson Laboratory. Commercial entities require a license from UC San Diego contact ( https://innovation.ucsd.edu/contact/).