The Wnt gene family is composed of a large number of secreted glycoproteins involved in a wide variety of cell interactions ranging from early to adult stage that play a role in morphogenesis, paterning and development. In contrast to the Wnt/β-catenin signaling pathway which most Wnt proteins signal through, Wnt-11 signals via the Wnt/JNK pathway. A recent study demonstrates that the expression of secreted factor Wnt-ll is elevated in several types of cancer, including colorectal cancer (2019 R. M. Kypta et al.)
The Wnt11flox allele has loxP sites flanking exon 4 of the wingless-type MMTV integration site family member 11 gene. Removal of the floxed sequence creates a null allele.
Wnt11flox mice may be useful in studying WNT signal transduction and WNT superfamily embryogenesis (e.g., kidney [ureteric bud branching morphogenesis], skeleton, lungs, etc.)
The mice are designated Tangible Research Material (TRM). A complete description, including genotyping, phenotyping, etc is found at The Jackson Lab cat. No. 030051; https://www.jax.org/strain/030051
Academic and non-profit institutions please order directly from The Jackson Laboratory. Commercial entities require a license from UC San Diego contact ( https://innovation.ucsd.edu/contact/).